Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 83721397

GI number: 83721397

Start: 1480299

End: 1482416

Strand: Reverse

Name: mutL [H]

Synonym: BTH_I1320

Alternate gene names: 83721397

Gene position: 1482416-1480299 (Counterclockwise)

Preceding gene: 83720378

Following gene: 83720662

Centisome position: 38.92

GC content: 71.48

Gene sequence:

>2118_bases
GTGAAATTTGGCCGACGAGCGACGTCGCGCACCGAACCCGGCAAGCGGTGCGTCGCGCGGCCTCGCTATAATTCCGCCAT
GTCCGAATTCACTGATTCCGCCGCGGGCCGCTCGGCCACGTCGCCCGCCGACGCATCCTCGTCCGCCTTGCGCCGTCTGC
GCGCGATCCAGCCGCTGCCCGACCAGTTGATCAGCCAGATCGCGGCGGGCGAAGTGGTCGAGCGGCCCGCGTCCGTCGTC
AAGGAGCTCGTCGAGAACGCGCTCGACGCCGGCGCGGGCACGCTGCGCATCCTGCTCGACGAAGGCGGCGTCAAGCGCAT
CTCGATCACCGACGACGGCTGCGGAATTCCCGCCGCCGAGCTGCCGCTCGCGCTGATGCGCCACGCAACGAGCAAGATCC
GCTCGCTCGCCGAGCTCGAGGCGGTCGCGACGCTCGGGTTCCGCGGCGAGGCGCTCGCGTCGATCGCATCGGTGGCCGAA
ATGTTCATCACGAGCCGCACCGAGGACGACGCGCACGCGACGCGCATCGACGCGCAGACAGGCGTGCTCGCGCCCGCGGC
CGGCACGCGCGGCACGACGATCGAAGTGCGCGAGCTGTACTTCAGCACGCCCGCGCGCCGCAAGTTCCTGAAGAGCGAGC
AGACCGAATTCGGCCATTGCCTCGAAATGATCCGCCGCGCGGCGCTCGCGCGGCCGGACGTCGCGATCTCGGTGCTGCAC
AACGGCCGCGCGGTCGAGCACTGGAACGCGAGCGAGCCCGCCGCGCGCGTCGCGAAAATTCTCGGCGACGGTTTCGCGAC
CGCCCACCTGCCGCTCGACGAGCGCGCCGGACCGCTCGCCGTCTACGGCTGCGCGGGGCTGCCGACCGCGAGCCGCGGCC
GCGCGGACCAGCAGTACTTCTTCGTCAACGGCCGCTTCGTGCGCGACAAGCTGCTCACGCACGCGGTGCGCGCCGCGTAC
GAGGACGTGCTGCACGGCGACCGCTACCCGTCGTACGTGCTGTTCCTCGATCTGCCGCCGGAAGCCGTCGACGTAAACGT
CCATCCGTCGAAGATCGAGGTGCGCTTTCGCGATTCGCGCTCGATCCACCAGTTCGTGTTCCACGCTGTGCAGCGCGCGC
TCGCGCGGCATGCCGGCGCGTCGCCGGAGACGACGGCGGGCGGCCACGCCGCGCACCTGTCGCCCGTCGAGCCGGCGCAG
GCCGGATCGCCGGCCGCGCCGAGCGCGTCGTTCGTCCGCCCGGACGCCGCGGCAGCAGGCGCGGGCGTCGGCCATCCCGC
GCCCGGCAACACGTGGCTGCGGCAATCGCGGATGACGCAGGGCACGCTGCCCGTCGCGCAACCGCTCGCGCTGTACGACG
CGCTGTTCGGCCGCAAGGATTCGGGCGCGGGCACGCCGCACGGCACGACGGGCGTGCTCGAGGCGCGCGACGCGCCGGAT
GCGCCTGGCGCGCCGCTCTTCGCGAGCGCGCCGGGCGGCGCCGCGATGCCCGCGTTCTCCGCGGCGGGCGCATCCGATCC
CGCGATGCACGACGAGCAGCCGCTCGGCTTCGCGGTCGGCCAGATCCACGGCATCTACGTGCTCGCGCAGAACGCGCGCG
GCCTCGTGATCGTCGACATGCACGCCGCGCACGAGCGGATCCTGTACGAGCAGTTCAAGCGCGCGCTCGCCGATCGGACA
GTCGCGGTGCAAACGCTGCTGATTCCGGTGTCGATGACGGCGACCCCCGTCGAGGTCGGCACAGCGGAAGAAGAACGCGA
GACGCTCGACGCGCTCGGCTTCGATCTCGCGGTGCTTTCGCCCACGACGCTCGCGATTCGCGCGGTGCCGGCGCTCTTGA
AGGACGCCGATCTGCAGGCGCTCGCGCGCGCGGTACTCGCCGATCTGCATGCGTTCGGCGGCTCGCGGGTGTTGACCGAG
CGCCAGCACGAACTGCTCGGCACGCTCGCGTGCCATCACGCGGTGCGCGCGAACCGGCGTCTCACGCTCGACGAGATGAA
CGCGCTGCTGCGGCAGATGGAGGCGACCGAGCGCGCGGATCAATGCAACCACGGCCGGCCGACCTGGTATCAACTGACGC
TCGGCGATCTCGACAAGCTCTTCATGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
TTCCTTGGTGTCGGTGACGAAGTGAGCGCGCGCCGGCCTCAAAGGGGCCGGAAGCAAAAAAAGCAACGCTGTCATGATAC
CGAAAGTGCCTTAAGCGACC

Downstream 100 bases:

>100_bases
GCGAATCCAACGCAGCATCCGTGCGCACGGTCGCGTGCCTGCTCGGCCCGACCGCGTCCGGCAAGACGGCCGCCGCGCTC
GCGCTCGCCGCGCGCCGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MKFGRRATSRTEPGKRCVARPRYNSAMSEFTDSAAGRSATSPADASSSALRRLRAIQPLPDQLISQIAAGEVVERPASVV
KELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPAAELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAE
MFITSRTEDDAHATRIDAQTGVLAPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLH
NGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAY
EDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLSPVEPAQ
AGSPAAPSASFVRPDAAAAGAGVGHPAPGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDSGAGTPHGTTGVLEARDAPD
APGAPLFASAPGGAAMPAFSAAGASDPAMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRT
VAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTE
RQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Sequences:

>Translated_705_residues
MKFGRRATSRTEPGKRCVARPRYNSAMSEFTDSAAGRSATSPADASSSALRRLRAIQPLPDQLISQIAAGEVVERPASVV
KELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPAAELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAE
MFITSRTEDDAHATRIDAQTGVLAPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLH
NGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAY
EDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLSPVEPAQ
AGSPAAPSASFVRPDAAAAGAGVGHPAPGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDSGAGTPHGTTGVLEARDAPD
APGAPLFASAPGGAAMPAFSAAGASDPAMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRT
VAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTE
RQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ
>Mature_705_residues
MKFGRRATSRTEPGKRCVARPRYNSAMSEFTDSAAGRSATSPADASSSALRRLRAIQPLPDQLISQIAAGEVVERPASVV
KELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPAAELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAE
MFITSRTEDDAHATRIDAQTGVLAPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLH
NGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAY
EDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLSPVEPAQ
AGSPAAPSASFVRPDAAAAGAGVGHPAPGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDSGAGTPHGTTGVLEARDAPD
APGAPLFASAPGGAAMPAFSAAGASDPAMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRT
VAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTE
RQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.5454545454545, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=28.4900284900285, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=28.4900284900285, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=29.9120234604106, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.5129682997118, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.5129682997118, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.4893617021277, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=23.5494880546075, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=24.3445692883895, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=24.3445692883895, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790612, Length=589, Percent_Identity=38.3701188455008, Blast_Score=313, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=33.75, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=25, Blast_Score=136, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=34.5047923322684, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=348, Percent_Identity=26.4367816091954, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=711, Percent_Identity=19.971870604782, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=404, Percent_Identity=23.7623762376238, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=33.8658146964856, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=25.2808988764045, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 75177; Mature: 75177

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGRRATSRTEPGKRCVARPRYNSAMSEFTDSAAGRSATSPADASSSALRRLRAIQPLP
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCH
DQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHH
LPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDDAHATRIDAQT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCC
GVLAPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLH
CEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
NGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYF
CCCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEE
FVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSR
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCC
SIHQFVFHAVQRALARHAGASPETTAGGHAAHLSPVEPAQAGSPAAPSASFVRPDAAAAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
AGVGHPAPGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDSGAGTPHGTTGVLEARDAPD
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCC
APGAPLFASAPGGAAMPAFSAAGASDPAMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDM
CCCCCEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHCEEEEEEEEECCCCEEEEEC
HAAHERILYEQFKRALADRTVAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECC
PTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MKFGRRATSRTEPGKRCVARPRYNSAMSEFTDSAAGRSATSPADASSSALRRLRAIQPLP
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCH
DQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHH
LPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDDAHATRIDAQT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCC
GVLAPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLH
CEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
NGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYF
CCCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEE
FVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSR
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCC
SIHQFVFHAVQRALARHAGASPETTAGGHAAHLSPVEPAQAGSPAAPSASFVRPDAAAAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
AGVGHPAPGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDSGAGTPHGTTGVLEARDAPD
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCC
APGAPLFASAPGGAAMPAFSAAGASDPAMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDM
CCCCCEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHCEEEEEEEEECCCCEEEEEC
HAAHERILYEQFKRALADRTVAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECC
PTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]