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The map label for this gene is cobW [H]

Identifier: 83720759

GI number: 83720759

Start: 2741263

End: 2742423

Strand: Reverse

Name: cobW [H]

Synonym: BTH_I2408

Alternate gene names: 83720759

Gene position: 2742423-2741263 (Counterclockwise)

Preceding gene: 83718602

Following gene: 83720397

Centisome position: 71.99

GC content: 68.99

Gene sequence:

>1161_bases
GTGACGTTTCCCCGTCAAGTTCCGCATGACCCGCGCGCGTTCGCGCACCGCCCTTACACTGACCCGATACCGACCAACGG
AACCACCATGCAGATGCGCAAAATCCCCGTGACGATCGTCACGGGCTTTCTCGGCAGCGGCAAGACGACGCTCTTGCGCC
ACATCCTCCGGCATGCGGGCGGCCGCCGGATCGTCGTGATCGTCAACGAGTTCGGCGAGCTCGGCATCGACGGCGAGATC
CTCAAGGGCTGCGGCATCGGCTGCGACGAAACCGGCCGCGAAGCCGACGGCCAGCTCTACGAGCTCGCGAACGGGTGCCT
GTGCTGCACCGTGCAGGAAGAGTTCTACCCGGTGATGGAAAAGCTCGTCGAGCGCCGCGCGGAGATCGACCACGTGCTGA
TCGAGACGTCCGGCCTCGCGTTGCCGAAGCCGCTCGTGCAGGCGTTCAACTGGCCGTCGATCAGGAACGGCTTCACGGTC
GACGCGGTGCTGACCGTCGTCGATGCGCCCGCCGCCGCGCTCGGGCAGTTCGCCGAGAACCCGGTCGCCGTCGACGCGCA
GCGCCGAGCGGACCCGAACCTCGATCACGAATCGCCGCTGCACGAGCTGTTCGCCGATCAATTGGCGTCCGCCGATCTCG
TGATCGTCAACAAGACCGATCTGCTCGACGACGCGGCGCTCGCGTCCGTCGAGACGGCGATCCGCGAGGAGGTGCCGCCG
CAGGTGAAGCTCGTGCGCGCGCAGCGCGGCGAACTCGATCTCGCGACGCTGCTCGGGCTGAACGCCGCGTCGGAAGAGAC
GATCCATCTGCGCCACGATCATCACGGCTCGGCCGACGATCCCGACCATCATCACGACGAGTTCGATTCGGTTGTCGTCG
AGGCGCGCGCGGGGTCGCGCGAGGCGGTGCTCGACGCGCTCGCGGCGCTCGTCGAGACGCACACGATCTATCGCGTGAAG
GGCTTCGCGGCGCTGCCCGGCGCGCCGATGCGGCTCGTCGTGCAGGGCGTCGGCCGGCGCTTCGACAGCTATTTCGACCG
CCGCTGGCGCGAAGGCGAAGCGCACCGGAGCCGCTTCGTGCTGATCGGCGAGGGGCTTGACGCGGCCGCGCTGCAGCGCG
CGTTCGACGCGGCGCTCGCCGCGCGCGGGCAGCCCGCGTGA

Upstream 100 bases:

>100_bases
TCGGCTACTTCGTGATCGGCCTCTTTGCCGCGAGCTGGATCGTCTCGGCGCTCATCTACCGGATCAGGCGCTACGACGAT
ATCGAGGTGACGATCTCCGT

Downstream 100 bases:

>100_bases
TGCGGCGGTAAGCGCAAGTGGAGCGGGAGTAGAGCGATGCATCTGTTGCGCACGACGCCTGGCGGCTTCGTCGACGATAC
GGCGGGCGTCGTCCGGATCG

Product: cobalamin synthesis protein/P47K family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTFPRQVPHDPRAFAHRPYTDPIPTNGTTMQMRKIPVTIVTGFLGSGKTTLLRHILRHAGGRRIVVIVNEFGELGIDGEI
LKGCGIGCDETGREADGQLYELANGCLCCTVQEEFYPVMEKLVERRAEIDHVLIETSGLALPKPLVQAFNWPSIRNGFTV
DAVLTVVDAPAAALGQFAENPVAVDAQRRADPNLDHESPLHELFADQLASADLVIVNKTDLLDDAALASVETAIREEVPP
QVKLVRAQRGELDLATLLGLNAASEETIHLRHDHHGSADDPDHHHDEFDSVVVEARAGSREAVLDALAALVETHTIYRVK
GFAALPGAPMRLVVQGVGRRFDSYFDRRWREGEAHRSRFVLIGEGLDAAALQRAFDAALAARGQPA

Sequences:

>Translated_386_residues
MTFPRQVPHDPRAFAHRPYTDPIPTNGTTMQMRKIPVTIVTGFLGSGKTTLLRHILRHAGGRRIVVIVNEFGELGIDGEI
LKGCGIGCDETGREADGQLYELANGCLCCTVQEEFYPVMEKLVERRAEIDHVLIETSGLALPKPLVQAFNWPSIRNGFTV
DAVLTVVDAPAAALGQFAENPVAVDAQRRADPNLDHESPLHELFADQLASADLVIVNKTDLLDDAALASVETAIREEVPP
QVKLVRAQRGELDLATLLGLNAASEETIHLRHDHHGSADDPDHHHDEFDSVVVEARAGSREAVLDALAALVETHTIYRVK
GFAALPGAPMRLVVQGVGRRFDSYFDRRWREGEAHRSRFVLIGEGLDAAALQRAFDAALAARGQPA
>Mature_385_residues
TFPRQVPHDPRAFAHRPYTDPIPTNGTTMQMRKIPVTIVTGFLGSGKTTLLRHILRHAGGRRIVVIVNEFGELGIDGEIL
KGCGIGCDETGREADGQLYELANGCLCCTVQEEFYPVMEKLVERRAEIDHVLIETSGLALPKPLVQAFNWPSIRNGFTVD
AVLTVVDAPAAALGQFAENPVAVDAQRRADPNLDHESPLHELFADQLASADLVIVNKTDLLDDAALASVETAIREEVPPQ
VKLVRAQRGELDLATLLGLNAASEETIHLRHDHHGSADDPDHHHDEFDSVVVEARAGSREAVLDALAALVETHTIYRVKG
FAALPGAPMRLVVQGVGRRFDSYFDRRWREGEAHRSRFVLIGEGLDAAALQRAFDAALAARGQPA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=364, Percent_Identity=29.9450549450549, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148727351, Length=366, Percent_Identity=29.7814207650273, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI33469141, Length=366, Percent_Identity=29.5081967213115, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI146231952, Length=366, Percent_Identity=29.2349726775956, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI223941779, Length=362, Percent_Identity=28.1767955801105, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI223941776, Length=365, Percent_Identity=28.2191780821918, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI119120938, Length=139, Percent_Identity=40.2877697841727, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082430, Length=355, Percent_Identity=28.7323943661972, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788499, Length=185, Percent_Identity=32.972972972973, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=380, Percent_Identity=25.5263157894737, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 42129; Mature: 41998

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPRQVPHDPRAFAHRPYTDPIPTNGTTMQMRKIPVTIVTGFLGSGKTTLLRHILRHAG
CCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHCC
GRRIVVIVNEFGELGIDGEILKGCGIGCDETGREADGQLYELANGCLCCTVQEEFYPVME
CCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEEEEHHHHHHHHH
KLVERRAEIDHVLIETSGLALPKPLVQAFNWPSIRNGFTVDAVLTVVDAPAAALGQFAEN
HHHHHHHHHCEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCC
PVAVDAQRRADPNLDHESPLHELFADQLASADLVIVNKTDLLDDAALASVETAIREEVPP
CEEECHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
QVKLVRAQRGELDLATLLGLNAASEETIHLRHDHHGSADDPDHHHDEFDSVVVEARAGSR
HHEEHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHEEEECCCCCH
EAVLDALAALVETHTIYRVKGFAALPGAPMRLVVQGVGRRFDSYFDRRWREGEAHRSRFV
HHHHHHHHHHHHHHHHEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LIGEGLDAAALQRAFDAALAARGQPA
EEECCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TFPRQVPHDPRAFAHRPYTDPIPTNGTTMQMRKIPVTIVTGFLGSGKTTLLRHILRHAG
CCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHCC
GRRIVVIVNEFGELGIDGEILKGCGIGCDETGREADGQLYELANGCLCCTVQEEFYPVME
CCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEEEEHHHHHHHHH
KLVERRAEIDHVLIETSGLALPKPLVQAFNWPSIRNGFTVDAVLTVVDAPAAALGQFAEN
HHHHHHHHHCEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCC
PVAVDAQRRADPNLDHESPLHELFADQLASADLVIVNKTDLLDDAALASVETAIREEVPP
CEEECHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
QVKLVRAQRGELDLATLLGLNAASEETIHLRHDHHGSADDPDHHHDEFDSVVVEARAGSR
HHEEHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHEEEECCCCCH
EAVLDALAALVETHTIYRVKGFAALPGAPMRLVVQGVGRRFDSYFDRRWREGEAHRSRFV
HHHHHHHHHHHHHHHHEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LIGEGLDAAALQRAFDAALAARGQPA
EEECCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]