Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 83720412

GI number: 83720412

Start: 2485871

End: 2487226

Strand: Reverse

Name: norM [H]

Synonym: BTH_I2211

Alternate gene names: 83720412

Gene position: 2487226-2485871 (Counterclockwise)

Preceding gene: 83718944

Following gene: 83720464

Centisome position: 65.3

GC content: 70.06

Gene sequence:

>1356_bases
ATGTTCGGCGACATCCGCCGGATCGCCGGTCTCGCCTGGCCGGTGCTCGTCGGCCAGCTCGCGATCATCGCGTTCGGCGT
GATCGACACCGCGATGGTCGGCCGCTTCTCCGCGCTCGATCTCGCGGCGCTCGGGCTCGGCACGTCGATCTACATATCGA
TCTATATCGGGCTGACGGGAATTCTGTCCGCGCTGCAGCCGATCGCGGGGCAACTGTACGGCGCGCGACGCTACGCGGAG
ATCGGCGAGGAGGTGCGCCAGGCGGCGTGGCTCGGCGTGCTGCTCGCGGTGCCCGGCTTTCTGCTGCTGCATTTCCCCCA
CCCGCTGCTGCGGCTCGCGCACGCGCCCGCCGAGCTCACCGAGCGCACGGTCGCCTATCTGCGCATCCTGTCGTTCGGGC
TGCCCGCGAGCCTCCTGTTCCGGATCTACAACGCGCTCACGAACGCGGCGGGCAAGCCGCGGCTCGCGATGATCCTGCAG
GTGGGCGCGCTCATCGTCAAAGTGCCGCTCAACATCTGGTTCATCTTCGGCGGCCTCGGCGTGCCGGCGCTCGGCGGCCC
CGGCTGCGGACTCGCAAGCACGCTGATCAACTGGGCGCTCGCGCTCGTCGGCTTCACGCTGCTCGCCAGGCTCGACGTGT
TCGAGCCGCTCGCGATCTTCGCGCGCTTCACGCGGCCCGTTTGGCATCGGCAGAAGGCACTCCTCACGCTCGGCGTGCCG
ATGGGGCTGTCGTATCTGATCGAGGTCACGTCGTACACGTTCATGGCGCTCTTCATCGCACAGTTCGGCACGACGACGCT
CGCCGGCCACCAGATCGCCGGCAACGTCGGCGCGGTGCTGTACATGACGCCGCTGTCGATCGGCGTCGCGTCGTCGACGC
TCGTCTCGCGCGCACTCGGCGCCCGGCGCTTCGACGAAGCGCGCGCGCTCGGCCGTCACGGCGTCGCGCTCGCGTGCGGG
CTCGCGTGCGTGTACGGCGTCGCCGTGTTCGCGCTGCGGCCGCTGATCGTGTCAGGCTACACGCCGAACCCGGCCATCGC
CGCGGCCGCGATGCCGCTCGTCGCGATCGTCACGTTCTATCACTTCTTCGACGCGCTGCAGATCACGACCGCGTTCGTGC
TGCGCGCGCACAAGGTCGCCGTCGTGCCGACCGCGATCTATGCGATCGCGCTGTGGGGCGTCGGGCTTGGCGGCGGATAC
CTGCTGGGGTTCGACGTCGGCGGCGCGGTGCCCGCGTCGCTCACCGGCGCGCGCGGCTTCTGGATCGCGAACACCGCGAG
CCTGATGCTCGCGGGCGGCGGGCTCGCGTTCTATCTGCGACGCATCGGGAAGCGGGAGCAAGACGGCGCGCGGTGA

Upstream 100 bases:

>100_bases
CCGCGTCGCCGACCGCGACGAGCGCTTCCGTCTGTACGAGCGGATCGAGCGCCCGAAGGCACCCATCAAGCGCCGCCCGC
CGCGCAAGGCCCGCTGACCG

Downstream 100 bases:

>100_bases
CCGCGGCAGGCTGTGAACGCGTCGCGGGCGCGCGCCGGATAGGCGGATACGCGCCCTTCGCGCCGCCTGCGTGCGGCTCG
CGACATCCCCGCCCGCGGCT

Product: multidrug resistance protein NorM

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGTSIYISIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAAWLGVLLAVPGFLLLHFPHPLLRLAHAPAELTERTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALIVKVPLNIWFIFGGLGVPALGGPGCGLASTLINWALALVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLTLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVASSTLVSRALGARRFDEARALGRHGVALACG
LACVYGVAVFALRPLIVSGYTPNPAIAAAAMPLVAIVTFYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPASLTGARGFWIANTASLMLAGGGLAFYLRRIGKREQDGAR

Sequences:

>Translated_451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGTSIYISIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAAWLGVLLAVPGFLLLHFPHPLLRLAHAPAELTERTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALIVKVPLNIWFIFGGLGVPALGGPGCGLASTLINWALALVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLTLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVASSTLVSRALGARRFDEARALGRHGVALACG
LACVYGVAVFALRPLIVSGYTPNPAIAAAAMPLVAIVTFYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPASLTGARGFWIANTASLMLAGGGLAFYLRRIGKREQDGAR
>Mature_451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGTSIYISIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAAWLGVLLAVPGFLLLHFPHPLLRLAHAPAELTERTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALIVKVPLNIWFIFGGLGVPALGGPGCGLASTLINWALALVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLTLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVASSTLVSRALGARRFDEARALGRHGVALACG
LACVYGVAVFALRPLIVSGYTPNPAIAAAAMPLVAIVTFYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPASLTGARGFWIANTASLMLAGGGLAFYLRRIGKREQDGAR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=24.113475177305, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI48994890, Length=420, Percent_Identity=30.952380952381, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI226510954, Length=432, Percent_Identity=22.4537037037037, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320545, Length=457, Percent_Identity=24.72647702407, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321821, Length=332, Percent_Identity=22.8915662650602, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47612; Mature: 47612

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGTSIYISIYIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEHHHHHHHHH
ILSALQPIAGQLYGARRYAEIGEEVRQAAWLGVLLAVPGFLLLHFPHPLLRLAHAPAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
ERTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQVGALIVKVPLNIWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCC
VPALGGPGCGLASTLINWALALVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLTLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCH
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVASSTLVSRALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCEEEEEECHHHHHHHHHHHHHHHH
ARRFDEARALGRHGVALACGLACVYGVAVFALRPLIVSGYTPNPAIAAAAMPLVAIVTFY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGYLLGFDVGGAVPASLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCE
WIANTASLMLAGGGLAFYLRRIGKREQDGAR
EEECCHHHEEECCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGTSIYISIYIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEHHHHHHHHH
ILSALQPIAGQLYGARRYAEIGEEVRQAAWLGVLLAVPGFLLLHFPHPLLRLAHAPAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
ERTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQVGALIVKVPLNIWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCC
VPALGGPGCGLASTLINWALALVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLTLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCH
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVASSTLVSRALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCEEEEEECHHHHHHHHHHHHHHHH
ARRFDEARALGRHGVALACGLACVYGVAVFALRPLIVSGYTPNPAIAAAAMPLVAIVTFY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGYLLGFDVGGAVPASLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCE
WIANTASLMLAGGGLAFYLRRIGKREQDGAR
EEECCHHHEEECCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA