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The map label for this gene is guaD [H]

Identifier: 83720321

GI number: 83720321

Start: 1811459

End: 1812772

Strand: Reverse

Name: guaD [H]

Synonym: BTH_I1610

Alternate gene names: 83720321

Gene position: 1812772-1811459 (Counterclockwise)

Preceding gene: 83721228

Following gene: 83720294

Centisome position: 47.59

GC content: 70.32

Gene sequence:

>1314_bases
ATGACCCAAACCGCTTTCCGCGCCCGCCTGCTGAGGTTCGACGGCGACCCCGCGCAATCGGACGACGCGATCGCGCACGA
CGAAGACGGCCTCCTCGTCGTCGACGACGACGGGCGCGTCGTTGCGGCGGGCGCCTATGCGGCGCTCGCGCCACGCCTCG
CGCCCGACGCGACGCTCGTCGAAATGCGCGACAAGCTGATCGTGCCCGGCTTCATCGACACGCACGTCCACTATCCGCAG
ACCGAAATGATCGCGTCGCCGGCGCCGGGCCTGTTGCCGTGGCTCGACCGCTACACGTTCCCGACCGAGCGGCGCTTCGC
CGATTCCGCGCACGCGCGCGACGTCGCCGAGTTCTTCCTCGACACGCTGCTCGCATGCGGCACGACGACGGCGCTCGTCT
ACTGCACGGTGCACAAGCAGTCGGCCGACGCATTCTTCGACGCGAGCGACGCGCGCGGCCTGCGAATGGTCGCGGGCAAG
GTGCTGATGGACCGCCACTGCCCCGAGTTCCTGCGCGACACCGCGCAATCGGGCTACGACGACAGCGCCGAGCTGATCGC
CCGCTGGCACGGCCGCGGCCGGCAGCTGTACGCGCTCACGCCGCGCTTCGCGCCCACGTCGACGCACGAGCAGCTCGAGG
CGTGCGGCGCGCTCGCGAAGCTTCATCCGGACGTGTTCATCCAGAGCCACGTCGCGGAGAATCTCGACGAGATCCGCTGG
GCAGCCGAGCTGTTCCCCGAGCGGCGCAGCTATCTCGACGTCTACGATCATTACGGCCTGCTGCGCCGGCGCGCGGTCTA
CGGCCACTGCATCCATCTCGACGACGACGATCGCCGGCGCTTCGCCGAAACGGGCGCGATCGCCGCGCACTGCCCGACGT
CGAACCTGTTCCTCGGCAGCGGCCTGTTCGAGTTCGATCGCGCGAACGCGCGGCAGATGGCCGTCACGCTCGCGACCGAC
GTCGGCGGCGGCACGTCGTTCTCGATGCTGCAAACGATGAACGAGGCGCACAAGATCGCGCGGATGACGGGCCATCATCT
GAGCGCAACCCGGATGTTCTGGCTCGCGACGGCGGGCGCCGCGCACGCGCTCGACCTGGCGGACACGATCGGCACGCTCG
CGCCGCGCGCGGAAGCCGACTTCGTCGTGCTCGATCCGGCTGCGACGCCGCTGCTCGCACGCCGCACCGCGCGCGCGGAG
TCGCTCGAGGAATTGCTGTTCGCGCTCGCGCTGCTCGGCGACGATCGTGCGGTCTATCGCACGTATGCGGCCGGCCGCTG
CGTGCATCGGCGCGACGTCGCCGACGCGGGCTGA

Upstream 100 bases:

>100_bases
GGACGCCGCCGCGACGTGAAGCCCGCGATGTGGGTCGTGGCGGCGCTGTCGGTGCTACTCGTCGCGCAGCTCTGATTTCA
ATCGATACGGATTCCAAACG

Downstream 100 bases:

>100_bases
GCATGGTCTGAGCGCGTGAAGGCCGTCGAGGACGCGAGCCGCCCGGCGCGCCACGCGGCCGACGGGCCGGTCCGCACCGG
TCCGCGCTCGCCCCCTGCCC

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTQTAFRARLLRFDGDPAQSDDAIAHDEDGLLVVDDDGRVVAAGAYAALAPRLAPDATLVEMRDKLIVPGFIDTHVHYPQ
TEMIASPAPGLLPWLDRYTFPTERRFADSAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADAFFDASDARGLRMVAGK
VLMDRHCPEFLRDTAQSGYDDSAELIARWHGRGRQLYALTPRFAPTSTHEQLEACGALAKLHPDVFIQSHVAENLDEIRW
AAELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFEFDRANARQMAVTLATD
VGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPRAEADFVVLDPAATPLLARRTARAE
SLEELLFALALLGDDRAVYRTYAAGRCVHRRDVADAG

Sequences:

>Translated_437_residues
MTQTAFRARLLRFDGDPAQSDDAIAHDEDGLLVVDDDGRVVAAGAYAALAPRLAPDATLVEMRDKLIVPGFIDTHVHYPQ
TEMIASPAPGLLPWLDRYTFPTERRFADSAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADAFFDASDARGLRMVAGK
VLMDRHCPEFLRDTAQSGYDDSAELIARWHGRGRQLYALTPRFAPTSTHEQLEACGALAKLHPDVFIQSHVAENLDEIRW
AAELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFEFDRANARQMAVTLATD
VGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPRAEADFVVLDPAATPLLARRTARAE
SLEELLFALALLGDDRAVYRTYAAGRCVHRRDVADAG
>Mature_436_residues
TQTAFRARLLRFDGDPAQSDDAIAHDEDGLLVVDDDGRVVAAGAYAALAPRLAPDATLVEMRDKLIVPGFIDTHVHYPQT
EMIASPAPGLLPWLDRYTFPTERRFADSAHARDVAEFFLDTLLACGTTTALVYCTVHKQSADAFFDASDARGLRMVAGKV
LMDRHCPEFLRDTAQSGYDDSAELIARWHGRGRQLYALTPRFAPTSTHEQLEACGALAKLHPDVFIQSHVAENLDEIRWA
AELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGSGLFEFDRANARQMAVTLATDV
GGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGAAHALDLADTIGTLAPRAEADFVVLDPAATPLLARRTARAES
LEELLFALALLGDDRAVYRTYAAGRCVHRRDVADAG

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=421, Percent_Identity=32.0665083135392, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1789249, Length=417, Percent_Identity=48.2014388489209, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319963, Length=438, Percent_Identity=30.8219178082192, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24643849, Length=432, Percent_Identity=32.4074074074074, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48139; Mature: 48008

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRARLLRFDGDPAQSDDAIAHDEDGLLVVDDDGRVVAAGAYAALAPRLAPDATLV
CCCHHHHHHHHHCCCCCCCCCCCCEECCCCEEEECCCCCEEEECHHHHHCCCCCCCHHHH
EMRDKLIVPGFIDTHVHYPQTEMIASPAPGLLPWLDRYTFPTERRFADSAHARDVAEFFL
HHHCCEECCCCHHCCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DTLLACGTTTALVYCTVHKQSADAFFDASDARGLRMVAGKVLMDRHCPEFLRDTAQSGYD
HHHHHCCCCEEEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCC
DSAELIARWHGRGRQLYALTPRFAPTSTHEQLEACGALAKLHPDVFIQSHVAENLDEIRW
CHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AAELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCEEEECCCCCEEECC
GLFEFDRANARQMAVTLATDVGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGA
CCHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCC
AHALDLADTIGTLAPRAEADFVVLDPAATPLLARRTARAESLEELLFALALLGDDRAVYR
HHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TYAAGRCVHRRDVADAG
HHHHCCHHHHCCCCCCC
>Mature Secondary Structure 
TQTAFRARLLRFDGDPAQSDDAIAHDEDGLLVVDDDGRVVAAGAYAALAPRLAPDATLV
CCHHHHHHHHHCCCCCCCCCCCCEECCCCEEEECCCCCEEEECHHHHHCCCCCCCHHHH
EMRDKLIVPGFIDTHVHYPQTEMIASPAPGLLPWLDRYTFPTERRFADSAHARDVAEFFL
HHHCCEECCCCHHCCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DTLLACGTTTALVYCTVHKQSADAFFDASDARGLRMVAGKVLMDRHCPEFLRDTAQSGYD
HHHHHCCCCEEEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCC
DSAELIARWHGRGRQLYALTPRFAPTSTHEQLEACGALAKLHPDVFIQSHVAENLDEIRW
CHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AAELFPERRSYLDVYDHYGLLRRRAVYGHCIHLDDDDRRRFAETGAIAAHCPTSNLFLGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCEEEECCCCCEEECC
GLFEFDRANARQMAVTLATDVGGGTSFSMLQTMNEAHKIARMTGHHLSATRMFWLATAGA
CCHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCC
AHALDLADTIGTLAPRAEADFVVLDPAATPLLARRTARAESLEELLFALALLGDDRAVYR
HHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TYAAGRCVHRRDVADAG
HHHHCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]