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The map label for this gene is ahpC [H]

Identifier: 83720312

GI number: 83720312

Start: 2369710

End: 2370258

Strand: Reverse

Name: ahpC [H]

Synonym: BTH_I2092

Alternate gene names: 83720312

Gene position: 2370258-2369710 (Counterclockwise)

Preceding gene: 83720306

Following gene: 83721245

Centisome position: 62.22

GC content: 61.38

Gene sequence:

>549_bases
ATGAAGACCGTGGGCGATAAACTCGAAGCTTTCACCGTTGTGGCCGCGAAGCCGGGCTTCAACAACCACGAAGAAAACGG
CCAGTCGGCATTCGAGACCGTCACCGAAGCGTCGTTCCCGGGCAAGTGGAAGATCATCTATTTCTACCCGAAGGACTTCA
CGTTCGTCTGCCCGACGGAAATCGTCGAATTCGCGAAGCTCGCGAAGCAGTTCGAAGAGCGCGACGCCGTCCTGCTCGGC
GGCAGCTCGGACAACGAATTCGTCAAGCTCGCATGGCGCCGTGAGCACAAGGATCTCGACAAGCTGAACCACTACTCGTT
CGGCGACGTCAAGGGCGAGCTGATCGACCAGCTCGGCGTGCGCGACAAGGAAGCCGGCGTGGCCCTGCGCGCGACCTTCA
TCGTCGACCCGGACAACACGATCCAGCACGTGTCGGTGAACAACCTGAACGTCGGCCGCAGCCCGGAGGAAATCCTGCGC
ATTCTCGACGGCCTGCAAACGGACGAACTCTGCCCGTGCAACCGCGCGATCGGCGGCGCGACGCTGTAA

Upstream 100 bases:

>100_bases
TAGCGTTATAGTGCTTCCTATGCTGTCACGGAAACGTTGCAGCGCATCGGTAGCTTGACCGTCAGTAGCAGTTTTTCCCA
ACTTACACAGGAGCATCCGC

Downstream 100 bases:

>100_bases
GCGTCCGATGCACGAAGGCCCGCGGCGCTGCGTCTTGCCTGCGGGCTTTTTTAACGGCCCAATCATAGGAGATATCAATG
GAATTCATCGATTCGATTAA

Product: anti-oxidant AhpCTSA family protein

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLAKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEILR
ILDGLQTDELCPCNRAIGGATL

Sequences:

>Translated_182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLAKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEILR
ILDGLQTDELCPCNRAIGGATL
>Mature_182_residues
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTEIVEFAKLAKQFEERDAVLLG
GSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEILR
ILDGLQTDELCPCNRAIGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=39.7435897435897, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=39.7435897435897, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI32189392, Length=160, Percent_Identity=38.75, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI4505591, Length=172, Percent_Identity=33.1395348837209, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI32455266, Length=172, Percent_Identity=33.1395348837209, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI32455264, Length=172, Percent_Identity=33.1395348837209, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=32.7044025157233, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI33188454, Length=66, Percent_Identity=43.9393939393939, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4758638, Length=136, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786822, Length=171, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=37.0860927152318, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=35.8490566037736, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=35.8490566037736, Blast_Score=116, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25153706, Length=144, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323613, Length=159, Percent_Identity=40.8805031446541, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=38.9937106918239, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=135, Percent_Identity=30.3703703703704, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=36.4779874213836, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=36.4779874213836, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=35.9477124183007, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357347, Length=149, Percent_Identity=35.5704697986577, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656348, Length=153, Percent_Identity=33.9869281045752, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17864676, Length=153, Percent_Identity=33.9869281045752, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=29.746835443038, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20305; Mature: 20305

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFAKLAKQFEERDAVLLGGSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEILRILDGLQTDELCPCNRAIGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKTVGDKLEAFTVVAAKPGFNNHEENGQSAFETVTEASFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFAKLAKQFEERDAVLLGGSSDNEFVKLAWRREHKDLDKLNHYSFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRSPEEILRILDGLQTDELCPCNRAIGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]