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The map label for this gene is lpd [H]

Identifier: 83720184

GI number: 83720184

Start: 2111308

End: 2113077

Strand: Direct

Name: lpd [H]

Synonym: BTH_I1866

Alternate gene names: 83720184

Gene position: 2111308-2113077 (Clockwise)

Preceding gene: 83720698

Following gene: 83719638

Centisome position: 55.43

GC content: 66.44

Gene sequence:

>1770_bases
ATGAGTCTCATCGAAGTCAAGGTTCCGGATATTGGCGATTTCAGCGGCGTCGATGTCATCGAAGTCAACGTGAAGCCGGG
CGACGTGATCGAAAAGGAGCAAACGCTCCTCACGCTCGAATCGGACAAGGCATCCATGGAAGTGCCGAGCGACGTCGCCG
GCACGGTGAAGGAAATCAAGGTCAAGGCCGGCGACAAGGTCTCGCAGGGCACGGTCATCGCGCTCGTCGAAGCATCGGCA
GGCGCGGCCGCGCCCGCGAAAGCGGCCGAACCGGCCAAGCCCGCCGTGCCGGCTCCGGCCGCCGCGCCCGCCGCCGCACC
GGCGAGCGCGCCGCAGGCCGGCAGCTACGCCGGCGCGGCGGACATCGAGTGCGACATGCTCGTGCTCGGCGCCGGCCCCG
GCGGCTACTCGGCCGCGTTCCGCGCAGCCGATCTCGGCATGAAGACGGTGCTTGTCGAACGCTATTCGACGCTCGGCGGC
GTGTGTCTGAACGTCGGCTGCATCCCGTCGAAGGCGCTGCTGCACACGGCGCTCGTCGTCGAGGAAGCCGAGGCGCTCGC
GTCGCACGGCATCTCGTTCGGCAAGCCGCAAGTCGACCTCGACAAGCTGCGCGACTTCAAGGGCGGCGTCGTCAAGAAGC
TGACGACGGGCCTCGCCGGCATGGCGAAGGCGCGCAAGGTCGAAGTCGTCACGGGCGTCGGCGCGTTCGTCGATCCGTAC
CACATGGAAGTGCAGGGCGAAGGCGGCAAGAAGGTCGTCAAGTTCAAGCAGGCGATCATCGCCGCGGGTTCGCAGGCCGT
GAAGCTGCCGTTCATGCCGGAAGACCCGCGCGTCGTCGATTCGACGGGCGCGCTCGAACTGCGCCAGTTGCCCAAGCGGA
TGCTCGTGATCGGCGGCGGCATCATCGGCCTCGAAATGGCGACGGTGTATTCGACGCTCGGCGCGGAGATCGACGTCGTC
GAAATGATGGACGGCCTGATGATGGGCGCGGACCGCGACCTCGTGAAGGTCTGGGAAAAGTACAACGCGAAGCGCTTCGG
CAACGTGATGCTGAAGACGAAGACGGTCGGCGCGCAAGCGAAGGAAGACGGCATCTACGTGAAGTTCGAGGGCGAGAAGG
CGCCGGCGGAAGCGCAGCGCTACGATCTCGTGCTCGTCGCGGTGGGCCGCAGCCCGAACGGCAAGAAGATCGGCGCCGAG
AAGGCCGGCGTCGCCGTCACGGAGCGCGGCTTCATCGACGTCGACAAGCAGATGCGCACGAACGTCCCGCACATCTTCGC
GATCGGCGACATCGTCGGCCAGCCGATGCTCGCGCACAAGGCGGTGCACGAAGGCCACGTCGCGGCCGAGGCGGCGCACG
GCGAGAAGGCCTATTTCGACGCGTTGCAGATTCCGTCGGTGGCCTATACCGATCCGGAAGTCGCATGGGCGGGCAAGACG
GAAGACCAGTGCAAGGCCGAAGGCATCAAGTACGGCAAGGCGGTGTTCCCGTGGGCGGCATCGGGTCGCGCGATCGCGAA
CGGTCGCGACGAGGGCTTCACGAAGCTGATCTTCGACGAGCAAACGCATCGCGTGATCGGCGGCGGCATCGTCGGTCTGA
ACGCGGGCGACCTCATCAGCGAAGTGTGCCTCGCGGTCGAGATGGGCGCGGACGCGCAAGACATCGGCAAGACGATCCAT
CCGCACCCGACGCTCGGCGAATCGGTCGGCATGGCCGCCGAGCTGTACGAAGGCGTCTGCACGGACCTGCCGCCGCAACG
TAAGAAGTAG

Upstream 100 bases:

>100_bases
TCCAGCCCAGGTTCGCGTTCTCTTGTCCGGCCGTAGTCGCAACGGGTTCTTTTGCGGGTTGCTCCCCCTCTGTCTGCAGC
TAATCAAGAAGGGGACAGTC

Downstream 100 bases:

>100_bases
TCATCGCGGCCGGCAGGCTGCGACGGCGCGAAAACGGCGCCTCCCGAAACGAACCGCACTCCGAAACCCGGCATCCGGCT
TCGCGAGATCGGTTCAAAAA

Product: pyruvate dehydrogenase, E3 component, dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MSLIEVKVPDIGDFSGVDVIEVNVKPGDVIEKEQTLLTLESDKASMEVPSDVAGTVKEIKVKAGDKVSQGTVIALVEASA
GAAAPAKAAEPAKPAVPAPAAAPAAAPASAPQAGSYAGAADIECDMLVLGAGPGGYSAAFRAADLGMKTVLVERYSTLGG
VCLNVGCIPSKALLHTALVVEEAEALASHGISFGKPQVDLDKLRDFKGGVVKKLTTGLAGMAKARKVEVVTGVGAFVDPY
HMEVQGEGGKKVVKFKQAIIAAGSQAVKLPFMPEDPRVVDSTGALELRQLPKRMLVIGGGIIGLEMATVYSTLGAEIDVV
EMMDGLMMGADRDLVKVWEKYNAKRFGNVMLKTKTVGAQAKEDGIYVKFEGEKAPAEAQRYDLVLVAVGRSPNGKKIGAE
KAGVAVTERGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSVAYTDPEVAWAGKT
EDQCKAEGIKYGKAVFPWAASGRAIANGRDEGFTKLIFDEQTHRVIGGGIVGLNAGDLISEVCLAVEMGADAQDIGKTIH
PHPTLGESVGMAAELYEGVCTDLPPQRKK

Sequences:

>Translated_589_residues
MSLIEVKVPDIGDFSGVDVIEVNVKPGDVIEKEQTLLTLESDKASMEVPSDVAGTVKEIKVKAGDKVSQGTVIALVEASA
GAAAPAKAAEPAKPAVPAPAAAPAAAPASAPQAGSYAGAADIECDMLVLGAGPGGYSAAFRAADLGMKTVLVERYSTLGG
VCLNVGCIPSKALLHTALVVEEAEALASHGISFGKPQVDLDKLRDFKGGVVKKLTTGLAGMAKARKVEVVTGVGAFVDPY
HMEVQGEGGKKVVKFKQAIIAAGSQAVKLPFMPEDPRVVDSTGALELRQLPKRMLVIGGGIIGLEMATVYSTLGAEIDVV
EMMDGLMMGADRDLVKVWEKYNAKRFGNVMLKTKTVGAQAKEDGIYVKFEGEKAPAEAQRYDLVLVAVGRSPNGKKIGAE
KAGVAVTERGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSVAYTDPEVAWAGKT
EDQCKAEGIKYGKAVFPWAASGRAIANGRDEGFTKLIFDEQTHRVIGGGIVGLNAGDLISEVCLAVEMGADAQDIGKTIH
PHPTLGESVGMAAELYEGVCTDLPPQRKK
>Mature_588_residues
SLIEVKVPDIGDFSGVDVIEVNVKPGDVIEKEQTLLTLESDKASMEVPSDVAGTVKEIKVKAGDKVSQGTVIALVEASAG
AAAPAKAAEPAKPAVPAPAAAPAAAPASAPQAGSYAGAADIECDMLVLGAGPGGYSAAFRAADLGMKTVLVERYSTLGGV
CLNVGCIPSKALLHTALVVEEAEALASHGISFGKPQVDLDKLRDFKGGVVKKLTTGLAGMAKARKVEVVTGVGAFVDPYH
MEVQGEGGKKVVKFKQAIIAAGSQAVKLPFMPEDPRVVDSTGALELRQLPKRMLVIGGGIIGLEMATVYSTLGAEIDVVE
MMDGLMMGADRDLVKVWEKYNAKRFGNVMLKTKTVGAQAKEDGIYVKFEGEKAPAEAQRYDLVLVAVGRSPNGKKIGAEK
AGVAVTERGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSVAYTDPEVAWAGKTE
DQCKAEGIKYGKAVFPWAASGRAIANGRDEGFTKLIFDEQTHRVIGGGIVGLNAGDLISEVCLAVEMGADAQDIGKTIHP
HPTLGESVGMAAELYEGVCTDLPPQRKK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=454, Percent_Identity=41.8502202643172, Blast_Score=338, Evalue=1e-92,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.6824034334764, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI291045266, Length=432, Percent_Identity=27.3148148148148, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI148277071, Length=448, Percent_Identity=25.2232142857143, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI33519430, Length=448, Percent_Identity=25.2232142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI33519428, Length=448, Percent_Identity=25.2232142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI33519426, Length=448, Percent_Identity=25.2232142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI148277065, Length=448, Percent_Identity=25.2232142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI22035672, Length=455, Percent_Identity=27.032967032967, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI291045268, Length=425, Percent_Identity=25.8823529411765, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786307, Length=473, Percent_Identity=65.53911205074, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=27.8617710583153, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=25.7777777777778, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789915, Length=444, Percent_Identity=28.8288288288288, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786305, Length=73, Percent_Identity=60.2739726027397, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=42.0824295010846, Blast_Score=344, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=26.9311064718163, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=26.1904761904762, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=26.1904761904762, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=441, Percent_Identity=24.7165532879819, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=457, Percent_Identity=40.4814004376368, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=27.9317697228145, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.0386266094421, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21358499, Length=453, Percent_Identity=43.7086092715232, Blast_Score=355, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24640551, Length=511, Percent_Identity=27.5929549902153, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=27.9166666666667, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=27.5933609958506, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17737741, Length=470, Percent_Identity=24.468085106383, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 61525; Mature: 61393

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIEVKVPDIGDFSGVDVIEVNVKPGDVIEKEQTLLTLESDKASMEVPSDVAGTVKEIK
CCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCHHHEE
VKAGDKVSQGTVIALVEASAGAAAPAKAAEPAKPAVPAPAAAPAAAPASAPQAGSYAGAA
EECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DIECDMLVLGAGPGGYSAAFRAADLGMKTVLVERYSTLGGVCLNVGCIPSKALLHTALVV
CCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
EEAEALASHGISFGKPQVDLDKLRDFKGGVVKKLTTGLAGMAKARKVEVVTGVGAFVDPY
HHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCE
HMEVQGEGGKKVVKFKQAIIAAGSQAVKLPFMPEDPRVVDSTGALELRQLPKRMLVIGGG
EEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEECCCCCHHHHHCCCEEEEECCC
IIGLEMATVYSTLGAEIDVVEMMDGLMMGADRDLVKVWEKYNAKRFGNVMLKTKTVGAQA
CHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHCHHHHCCEEEEEEECCCCC
KEDGIYVKFEGEKAPAEAQRYDLVLVAVGRSPNGKKIGAEKAGVAVTERGFIDVDKQMRT
CCCCEEEEECCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEECCHHHHC
NVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSVAYTDPEVAWAGKT
CCCEEEEEHHHHCCCHHHHHHHHCCCHHEECCCCCHHHHHHHCCCCEEECCCCEEECCCC
EDQCKAEGIKYGKAVFPWAASGRAIANGRDEGFTKLIFDEQTHRVIGGGIVGLNAGDLIS
HHHHHHCCCCCCCEECCCCCCCCEEECCCCCCCEEEEECCCCCEEECCCEEECCHHHHHH
EVCLAVEMGADAQDIGKTIHPHPTLGESVGMAAELYEGVCTDLPPQRKK
HHHHHHHCCCCHHHHCCCCCCCCCCCHHHCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLIEVKVPDIGDFSGVDVIEVNVKPGDVIEKEQTLLTLESDKASMEVPSDVAGTVKEIK
CEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCHHHEE
VKAGDKVSQGTVIALVEASAGAAAPAKAAEPAKPAVPAPAAAPAAAPASAPQAGSYAGAA
EECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DIECDMLVLGAGPGGYSAAFRAADLGMKTVLVERYSTLGGVCLNVGCIPSKALLHTALVV
CCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
EEAEALASHGISFGKPQVDLDKLRDFKGGVVKKLTTGLAGMAKARKVEVVTGVGAFVDPY
HHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCE
HMEVQGEGGKKVVKFKQAIIAAGSQAVKLPFMPEDPRVVDSTGALELRQLPKRMLVIGGG
EEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEECCCCCHHHHHCCCEEEEECCC
IIGLEMATVYSTLGAEIDVVEMMDGLMMGADRDLVKVWEKYNAKRFGNVMLKTKTVGAQA
CHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHCHHHHCCEEEEEEECCCCC
KEDGIYVKFEGEKAPAEAQRYDLVLVAVGRSPNGKKIGAEKAGVAVTERGFIDVDKQMRT
CCCCEEEEECCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEECCHHHHC
NVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSVAYTDPEVAWAGKT
CCCEEEEEHHHHCCCHHHHHHHHCCCHHEECCCCCHHHHHHHCCCCEEECCCCEEECCCC
EDQCKAEGIKYGKAVFPWAASGRAIANGRDEGFTKLIFDEQTHRVIGGGIVGLNAGDLIS
HHHHHHCCCCCCCEECCCCCCCCEEECCCCCCCEEEEECCCCCEEECCCEEECCHHHHHH
EVCLAVEMGADAQDIGKTIHPHPTLGESVGMAAELYEGVCTDLPPQRKK
HHHHHHHCCCCHHHHCCCCCCCCCCCHHHCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]