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The map label for this gene is hemE [H]

Identifier: 83719923

GI number: 83719923

Start: 3764128

End: 3765222

Strand: Reverse

Name: hemE [H]

Synonym: BTH_I3304

Alternate gene names: 83719923

Gene position: 3765222-3764128 (Counterclockwise)

Preceding gene: 83719308

Following gene: 83719363

Centisome position: 98.85

GC content: 69.5

Gene sequence:

>1095_bases
GTGGCCCAGACTCTCATCAACGACACCTTCCTGCGCGCGCTGCTGCGCGAGCCGACCGACTACACGCCGATCTGGCTGAT
GCGCCAGGCGGGCCGCTACCTGCCCGAGTACAACGCCACGCGCGCGCGCGCCGGCAGCTTTCTCGGGCTCGCGAAGCATC
CCGATTACGCGACCGAGGTGACGCTGCAGCCGCTCGAGCGCTTCCCGCTCGACGCCGCGATCCTGTTTTCCGACATCCTG
ACGATTCCCGACGCGATGGGGCTCGGCCTCGATTTCGCCGCGGGCGAGGGGCCGAAGTTCGCGCATCCGGTGCGCACCGA
GGCCGATGTCGCGAAGCTCGCGGTGCCGGACATCGGCGCGACGCTCGGCTACGTGACCGACGCGGTGCGAGAGATTCGCC
GCGCGCTCACCGACGGCGAAGGTCGCCAGCGTGTGCCGCTGATCGGTTTCTCCGGCAGCCCGTGGACGCTCGCGTGCTAC
ATGGTGGAAGGCGGCGGCTCGGACGATTTCCGCACGGTGAAGTCGATGGCGTATGCGCGGCCTGACCTGATGCACCGCAT
TCTCGACGTGAACGCGCAGGCAGTGGCCGCATACCTGAACGCGCAGATCGAAGCCGGCGCGCAGGCCGTGATGATCTTCG
ATACCTGGGGAGGCGCGCTGGCCGACGGCGCGTATCAGCGCTTCTCGCTCGACTACATCCGGCGCGTCGTCGCGCAGTTG
AAACGCGAGCACGACGGCGCGCGCGTGCCGGCGATCGCGTTCACGAAGGGCGGCGGGCTCTGGCTCGAAGACTTGGCGGC
GACGGGCGTCGACGCGGTCGGCCTCGACTGGACGGTCAACCTCGGCCGCGCGCGCGAGCGCGTCGCGGGGCGCGTCGCGC
TGCAGGGCAACCTCGATCCGACGATCCTGTTCGCGCCGCCCGAGGCGATTCGCGCCGAGGCGCGCGCGGTGCTCGACAGC
TACGGCAATCACCCGGGCCACGTGTTCAACCTGGGCCACGGCATTTCGCAGTTCACGCCGCCCGAGCACGTTGCGGAGCT
CGTAGACGAAGTGCATCGCCATAGCCGCGCGATCCGGAGCGGAACCGGATCGTAA

Upstream 100 bases:

>100_bases
TCATAACGGACGGCCGGCGAGCGTCATATGGCCGCGAGCGCCGGGCGGCGCGCCGCGTCCGGTAGAATGCTCCTTTGCGT
TTCGCTTTGTCGCACTCATC

Downstream 100 bases:

>100_bases
TCGCAAGCCGTCCGATGCTGCGACGCGACGCGACGGGTTTGCGCAAACGCGACTAAACAGGGCGCAAGCGCCCGTCCGAT
GGTGCTCTTCTGCTTGTCAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAQTLINDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKHPDYATEVTLQPLERFPLDAAILFSDIL
TIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACY
MVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQL
KREHDGARVPAIAFTKGGGLWLEDLAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDS
YGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGTGS

Sequences:

>Translated_364_residues
MAQTLINDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKHPDYATEVTLQPLERFPLDAAILFSDIL
TIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACY
MVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQL
KREHDGARVPAIAFTKGGGLWLEDLAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDS
YGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGTGS
>Mature_363_residues
AQTLINDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKHPDYATEVTLQPLERFPLDAAILFSDILT
IPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYM
VEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQLK
REHDGARVPAIAFTKGGGLWLEDLAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDSY
GNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGTGS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=48.4764542936288, Blast_Score=324, Evalue=9e-89,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=62.1082621082621, Blast_Score=443, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320252, Length=363, Percent_Identity=36.6391184573003, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=38.5269121813031, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=38.5269121813031, Blast_Score=248, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39497; Mature: 39366

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTLINDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKHPDYATEV
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCCHHH
TLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCHH
TLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYAR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCC
PDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQL
HHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHH
KREHDGARVPAIAFTKGGGLWLEDLAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDP
HHHCCCCCCCEEEEECCCCCCHHHHHHCCCCEECCCEEEECHHHHHHHHCEEEEECCCCC
TILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GTGS
CCCC
>Mature Secondary Structure 
AQTLINDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKHPDYATEV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCCHHH
TLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCHH
TLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYAR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCC
PDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYIRRVVAQL
HHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHH
KREHDGARVPAIAFTKGGGLWLEDLAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDP
HHHCCCCCCCEEEEECCCCCCHHHHHHCCCCEECCCEEEECHHHHHHHHCEEEEECCCCC
TILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GTGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA