Click here to switch to the map view.

The map label for this gene is amrR [H]

Identifier: 83719767

GI number: 83719767

Start: 2800632

End: 2801261

Strand: Direct

Name: amrR [H]

Synonym: BTH_I2446

Alternate gene names: 83719767

Gene position: 2800632-2801261 (Clockwise)

Preceding gene: 83721627

Following gene: 83719735

Centisome position: 73.52

GC content: 68.73

Gene sequence:

>630_bases
ATGGCCCGCAAGACGCGCGAAGAGTCGCTGAACACGAAGAACCGGATCCTCGACGCCGCCGAGCTCGTGCTGCTGGAAAG
GGGCGTCGGCCAGACCGCGATGGCCGACATCGCGGAGGCGGCCGGCATGTCGCGCGGCGCGGTCTACGGGCACTTCAAGG
GCAAGATCGAGGTGTGCGTGGCGGTGTGCGACCGTGCGTTCTCGCGCGCGGCCGAGGGCTTCGATCTGTCCGACGAGCGG
CCCGCGCTCGCGACGCTGCGGCTCGCCGCGTCGCACTATCTGCATCAATGCGGCGAACCCGGCTCGATGCAGCGCGTGCT
CGAGATCCTCTACATGAAATGCGAGCACAGCGAAGAAAACGCGCCGCTGATGCGCCGGCGCACGCTCTACGAATTGCAGA
CGCTGCGCATCGTCAAGGCATTGCTGCGCCGCGCGGTCGCCGCGGGCGAACTCGACGCGTCGCTCGACGTGCATCTCGCG
GGCGTCTATCTGCTGTCGCTGCTCGAGGGCATCTTCGGCTCGATGATGTGGTCGGCTCGGCTGCGCGGCGATCGATGGCG
CGACGCCGAAGCGATGCTCGACGCGGGCGTCGATACGCTGCGCGCATCGCCCGCGCTGCGCGCGGCCTAA

Upstream 100 bases:

>100_bases
TCGGGGCGATCGATTATAATCAGTCACGATTGATTAAATAATGTCGTCCGACATATTGTCGTAAGAAAGCGACACGGATT
TGAAAGGGAGCATCACCCAC

Downstream 100 bases:

>100_bases
GATTGCGCATCGCGCGCTTTGTCGCGCGCCAATGCGCGCCAAGCGCGCATCGAGCGCTTTGAGTATCCGCCCCCACATAA
AAATATCGAGTTCTCCGGAA

Product: regulator AmrR

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MARKTREESLNTKNRILDAAELVLLERGVGQTAMADIAEAAGMSRGAVYGHFKGKIEVCVAVCDRAFSRAAEGFDLSDER
PALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEHSEENAPLMRRRTLYELQTLRIVKALLRRAVAAGELDASLDVHLA
GVYLLSLLEGIFGSMMWSARLRGDRWRDAEAMLDAGVDTLRASPALRAA

Sequences:

>Translated_209_residues
MARKTREESLNTKNRILDAAELVLLERGVGQTAMADIAEAAGMSRGAVYGHFKGKIEVCVAVCDRAFSRAAEGFDLSDER
PALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEHSEENAPLMRRRTLYELQTLRIVKALLRRAVAAGELDASLDVHLA
GVYLLSLLEGIFGSMMWSARLRGDRWRDAEAMLDAGVDTLRASPALRAA
>Mature_208_residues
ARKTREESLNTKNRILDAAELVLLERGVGQTAMADIAEAAGMSRGAVYGHFKGKIEVCVAVCDRAFSRAAEGFDLSDERP
ALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEHSEENAPLMRRRTLYELQTLRIVKALLRRAVAAGELDASLDVHLAG
VYLLSLLEGIFGSMMWSARLRGDRWRDAEAMLDAGVDTLRASPALRAA

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=183, Percent_Identity=27.3224043715847, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=28.0788177339901, Blast_Score=71, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23017; Mature: 22886

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTREESLNTKNRILDAAELVLLERGVGQTAMADIAEAAGMSRGAVYGHFKGKIEVCV
CCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHH
AVCDRAFSRAAEGFDLSDERPALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEHSEEN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
APLMRRRTLYELQTLRIVKALLRRAVAAGELDASLDVHLAGVYLLSLLEGIFGSMMWSAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGDRWRDAEAMLDAGVDTLRASPALRAA
HCCCCCHHHHHHHHHCHHHHHCCCCCCCC
>Mature Secondary Structure 
ARKTREESLNTKNRILDAAELVLLERGVGQTAMADIAEAAGMSRGAVYGHFKGKIEVCV
CCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHH
AVCDRAFSRAAEGFDLSDERPALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEHSEEN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
APLMRRRTLYELQTLRIVKALLRRAVAAGELDASLDVHLAGVYLLSLLEGIFGSMMWSAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGDRWRDAEAMLDAGVDTLRASPALRAA
HCCCCCHHHHHHHHHCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]