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The map label for this gene is bioA [H]

Identifier: 83719742

GI number: 83719742

Start: 376514

End: 377860

Strand: Reverse

Name: bioA [H]

Synonym: BTH_I0340

Alternate gene names: 83719742

Gene position: 377860-376514 (Counterclockwise)

Preceding gene: 83720690

Following gene: 83718450

Centisome position: 9.92

GC content: 69.19

Gene sequence:

>1347_bases
TTGAGCACACACGCAACCGACGACTGGGTCGCGCGCAGCCTGCGCGCGGTCTGGCATCCTTGCACGCAGATGAAGCACCA
CGAGCGGCTGCCGCTCATTCCCGTCGCGCGCGGCGAACGCGCGTGGCTGTTCGATCGCGCGGGCAACCGCTATCTCGACG
CGATCAGTTCGTGGTGGGTGAACCTGTTCGGCCACGCGAACCCGCGCATCAACGCGGCGCTCAAGCAGCAGCTCGACACG
CTCGAGCACGCGATGCTCGCCGGCTGCACGCACGAAAGCGCGATCGAGCTTGCCGAGCGGCTCGCCGCGCGCACGCAGCA
CACGCTCGGCCATGCGTTCTTTGCATCGGACGGCGCGTCGGCCGTCGAGATCGCGCTGAAGATGAGCTTCCACGCGTGGC
GCAACCGCGGCCGCGGCGACAAGCGCGAATTCGTCTGCATCGCGAACGGTTACCACGGCGAGACCATCGGCGCGCTCGGC
GTGACCGACGTCGCGCTGTTCAAGGACGCGTACGATCCGCTGATTCGCGCGGCGCACGTCGTCGCATCGCCGGACGCGCG
CGGCGCGCGCGACGGCGAAACGGCGGCCGACGTCGCCGCGCGCGCGCTCGGCGACGTGAAACGCCTGTTCGCCGAGCGCG
GCGAAAAGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCGGCCGGCTTCGCGATGCACGATCCGTCTTACGTG
CGCGGCCTGCGCGCGCTGTGCGACGCGCACGACGTGCATCTGATCGCCGACGAGATCGCGGTCGGCTGCGGGCGCACCGG
CACGTTCTTCGCATGCGAGCAGGCGCACGTGTGGCCCGATTTCCTGTGCCTGTCGAAGGGCATCAGCGGCGGCTACCTGC
CGCTGTCGCTCGTGCTGTCGCGCGACGCGATCTTCGACGCGTTCTACGACGACGACGTGACGCGCGGCTTTTTGCACTCG
CATTCGTACACGGGCAATCCGCTCGCGTGCCGCGCGGCCGTCGCGACGCTCGATCTGTTCGACACCGACGACGTGCTCGC
CGAAAACGCGCGCAAGTCCGCGCTGATGCGCGAAGCGCTCGCGCCGCTCGCGTCGCATCCGCAGGTGCGCCACCTGCGCG
AGCGCGGCACGATCTTCGCGTTCGACGTCGCGCTCGAAGGCGATGCGGCGAAAACGTTCCCGCGCCGCTTCTTCGAGCGC
GCGCTCGCACGCGAGACGCTGCTGCGCCCGATCGGCACGACGGTCTATCTGATGCCGCCTTACATCCTCGCCGACGGCGA
GATCGAATGGCTTGCATCGCGCACGCGCGCGACGCTCGACGCAACGCTTTCGGAGACTCACGCATGA

Upstream 100 bases:

>100_bases
CGTTTTCTTCGCCATCCGATCGCACGCGTTCTCGCCGTCGATCCCGCATGAGCGAGCGGCGCTTCGCGCGCCCTCGACGC
GTTTTGGTCCCGGAGCAGTC

Downstream 100 bases:

>100_bases
ATCTGCTCGCCACGCTCGAACGCGGCCTGGCCGACATCGACGCACAGGGGCTGCGCCGCCGCCGCCGCATCGCGGACACC
GCATGCAGCGCGCACATGAG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDT
LEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALG
VTDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVKRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHS
HSYTGNPLACRAAVATLDLFDTDDVLAENARKSALMREALAPLASHPQVRHLRERGTIFAFDVALEGDAAKTFPRRFFER
ALARETLLRPIGTTVYLMPPYILADGEIEWLASRTRATLDATLSETHA

Sequences:

>Translated_448_residues
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDT
LEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALG
VTDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVKRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHS
HSYTGNPLACRAAVATLDLFDTDDVLAENARKSALMREALAPLASHPQVRHLRERGTIFAFDVALEGDAAKTFPRRFFER
ALARETLLRPIGTTVYLMPPYILADGEIEWLASRTRATLDATLSETHA
>Mature_447_residues
STHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWVNLFGHANPRINAALKQQLDTL
EHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGASAVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGV
TDVALFKDAYDPLIRAAHVVASPDARGARDGETAADVAARALGDVKRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYVR
GLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLSRDAIFDAFYDDDVTRGFLHSH
SYTGNPLACRAAVATLDLFDTDDVLAENARKSALMREALAPLASHPQVRHLRERGTIFAFDVALEGDAAKTFPRRFFERA
LARETLLRPIGTTVYLMPPYILADGEIEWLASRTRATLDATLSETHA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=29.7560975609756, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI37574042, Length=365, Percent_Identity=27.1232876712329, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI226442705, Length=367, Percent_Identity=27.2479564032698, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI13994255, Length=386, Percent_Identity=25.6476683937824, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI284507298, Length=317, Percent_Identity=30.2839116719243, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI226442709, Length=334, Percent_Identity=26.3473053892216, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI24119277, Length=374, Percent_Identity=23.2620320855615, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786991, Length=444, Percent_Identity=36.9369369369369, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=29.5843520782396, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1789016, Length=359, Percent_Identity=30.6406685236769, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789759, Length=316, Percent_Identity=30.6962025316456, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788044, Length=398, Percent_Identity=28.643216080402, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787560, Length=427, Percent_Identity=29.2740046838407, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=25.8899676375405, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=26.1501210653753, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=338, Percent_Identity=27.5147928994083, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=222, Percent_Identity=30.1801801801802, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=366, Percent_Identity=24.3169398907104, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=448, Percent_Identity=29.4642857142857, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=25.7683215130024, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323470, Length=370, Percent_Identity=29.7297297297297, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=25.7756563245823, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161085790, Length=389, Percent_Identity=26.2210796915167, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574759, Length=389, Percent_Identity=26.2210796915167, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356575, Length=325, Percent_Identity=25.2307692307692, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49227; Mature: 49096

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHH
NLFGHANPRINAALKQQLDTLEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGAS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGVTDVALFKDAYDPLIRAAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VASPDARGARDGETAADVAARALGDVKRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLS
HHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
RDAIFDAFYDDDVTRGFLHSHSYTGNPLACRAAVATLDLFDTDDVLAENARKSALMREAL
HHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
APLASHPQVRHLRERGTIFAFDVALEGDAAKTFPRRFFERALARETLLRPIGTTVYLMPP
HHHHCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
YILADGEIEWLASRTRATLDATLSETHA
EEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STHATDDWVARSLRAVWHPCTQMKHHERLPLIPVARGERAWLFDRAGNRYLDAISSWWV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHH
NLFGHANPRINAALKQQLDTLEHAMLAGCTHESAIELAERLAARTQHTLGHAFFASDGAS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AVEIALKMSFHAWRNRGRGDKREFVCIANGYHGETIGALGVTDVALFKDAYDPLIRAAHV
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VASPDARGARDGETAADVAARALGDVKRLFAERGEKIAALIVEPLVQCAAGFAMHDPSYV
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHH
RGLRALCDAHDVHLIADEIAVGCGRTGTFFACEQAHVWPDFLCLSKGISGGYLPLSLVLS
HHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
RDAIFDAFYDDDVTRGFLHSHSYTGNPLACRAAVATLDLFDTDDVLAENARKSALMREAL
HHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
APLASHPQVRHLRERGTIFAFDVALEGDAAKTFPRRFFERALARETLLRPIGTTVYLMPP
HHHHCCHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
YILADGEIEWLASRTRATLDATLSETHA
EEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]