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The map label for this gene is livM [H]

Identifier: 83719557

GI number: 83719557

Start: 3789608

End: 3790582

Strand: Reverse

Name: livM [H]

Synonym: BTH_I3327

Alternate gene names: 83719557

Gene position: 3790582-3789608 (Counterclockwise)

Preceding gene: 83719683

Following gene: 83720623

Centisome position: 99.51

GC content: 66.67

Gene sequence:

>975_bases
ATGCAGAGAAAAGCGCTCTACGGGCTGTTGCTGGCCGGCCTGCTCGTCGCGCCGTTCGTCGGCGCGTATCCGGTGTTCAT
GATGAAGGTGCTGTGCTTCGCGCTCTTCGCGGCCGCGTTCAATCTGCTGATCGGGTTCACGGGCCTGCTGTCGTTCGGCC
ACGCGATGTTCCTCGCGACGGCGGGCTACGTGACGGGCTACGCGATGCAGTCGCTCGGCACGACGCCGGAGCTTGGCGTG
CTGGCCGGCACCATGGCGGCGACGCTGCTCGGCCTCGTTGTCGGCCTGTTCGCGATCCGGCGGCAGGGCATCTATTTCGC
GATGATCACGCTCGCGTTCGCGCAGATGGTGTATTTCATCTATCTGCAAGCGCCGTTCACGCACGGCGAGGACGGGCTGC
AAGGCGTACCGCGCGGGTGGCTGTTCGGGCTCGTCGATCTGTCGTCGGATCTCGCGCTCTATTACGTCGTGCTCGTCGTC
ATCGCATGCGCGTGCCTGTTCATCGTGCGCATCGTGCATTCGCCGTTTGGGCAGGTGCTCGTCGCGATCAAGGAGAACGA
GCCGCGCGCGACGTCGCTCGGCTACGATACCGATCGCTTCAAGCTGCTCGCGTTCATCCTGTCGGCCGCGCTCGCGGGGC
TTGCCGGCGCGTTGAAGGTTGTCGTGCTCGGCTTCGAGACGCTGAGCGACGCCTACTGGACGATGTCGGGCCTCGTCGTG
CTGATGACGCTCGTGGGCGGCATGGGCACGCTGTTCGGCCCGCTCGTCGGCGCGGCGCTGATCGTCGCGCTCGAGGATCG
GCTGGGCGACATCGGCGGCTGGCTCGCATCGGTCACGCACATCGACTGGTTCCGCTCGCTCGGCGAATCCGCGACGATCG
TCACGGGCCTCATCTTCATCGCTTGCGTGCTCGCGTTCAGGCGCGGGATCGTCGGCGAGGTGATCGCCCGGGTGCGGCCG
CTGCGGGCGTCGTGA

Upstream 100 bases:

>100_bases
CGCGCGTGTTCTATCCGGAGGCGTCGGCGACGGTCGTGTTCGTCATCATGGCGATCGTGCTGCTGATTCGCCCGGCAGGT
TTGTTCGGCAAGGAAAGATG

Downstream 100 bases:

>100_bases
GCGGCCAGGCGGAGCGATCGTGCGGTGCGCAATGAATCGTTGGGAATCCGATCCAATGCGCGCGGCAAACACCCGGCCCG
GCTCGGCCTGACGCGGCCGA

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQRKALYGLLLAGLLVAPFVGAYPVFMMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTTPELGV
LAGTMAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGWLFGLVDLSSDLALYYVVLVV
IACACLFIVRIVHSPFGQVLVAIKENEPRATSLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIACVLAFRRGIVGEVIARVRP
LRAS

Sequences:

>Translated_324_residues
MQRKALYGLLLAGLLVAPFVGAYPVFMMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTTPELGV
LAGTMAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGWLFGLVDLSSDLALYYVVLVV
IACACLFIVRIVHSPFGQVLVAIKENEPRATSLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIACVLAFRRGIVGEVIARVRP
LRAS
>Mature_324_residues
MQRKALYGLLLAGLLVAPFVGAYPVFMMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTTPELGV
LAGTMAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGWLFGLVDLSSDLALYYVVLVV
IACACLFIVRIVHSPFGQVLVAIKENEPRATSLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIACVLAFRRGIVGEVIARVRP
LRAS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=258, Percent_Identity=29.0697674418605, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 34526; Mature: 34526

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKALYGLLLAGLLVAPFVGAYPVFMMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQSLGTTPELGVLAGTMAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLQAPFTHGEDGLQGVPRGWLFGLVDLSSDLALYYVVLVVIACACLFIVRIVHSPFGQVL
HHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRATSLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ACVLAFRRGIVGEVIARVRPLRAS
HHHHHHHHCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQRKALYGLLLAGLLVAPFVGAYPVFMMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQSLGTTPELGVLAGTMAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLQAPFTHGEDGLQGVPRGWLFGLVDLSSDLALYYVVLVVIACACLFIVRIVHSPFGQVL
HHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRATSLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ACVLAFRRGIVGEVIARVRPLRAS
HHHHHHHHCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]