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The map label for this gene is hflK [H]

Identifier: 83719290

GI number: 83719290

Start: 2518891

End: 2520228

Strand: Direct

Name: hflK [H]

Synonym: BTH_I2241

Alternate gene names: 83719290

Gene position: 2518891-2520228 (Clockwise)

Preceding gene: 83720345

Following gene: 83721589

Centisome position: 66.13

GC content: 69.81

Gene sequence:

>1338_bases
ATGCGCGCCTTGCTGTCGATCAACGATCCCCGCTGGGGACGCGGCGGCAACGGCGACAAGCCGCGCGCGAACGAATCGAA
GCGCCCGAACGGCCGCGACGACGGCCCCCCGGATCTCGACGAAATGTGGCGGAACTTCAACCGCCGCCTGAGCGGCTGGT
TCGGCGGCAAGGGCGGCGGCAACAATGGCTTTCGTCCCGACAACGGACGTGCCGCGCGCGTCGGCGTCGGCATTGTCGCG
GGCGTGCTGATCGCAATCTACCTCGGCAGCGGCATCTTCATCGTCCAGGACGGCCAGACGGGCGTCGTGCTGCGCTTCGG
CGAATACAAGGGCTCGGTCGGCGACGGCGTTCACTGGCGTCTGCCGTATCCGTTCGAATCGCACGAGATCGTTGACACCG
CGCAGGTGCGCTCGATCGAGATCGGCCGCAACAACGTCGTGCGGCTCGCGAACGTGAAGGACGCGTCGATGCTCACGCGC
GACGCCGACATCGTCGACGTGCGTTTCGCCGTTCAATATCGGATCGGGTCCCCGACCGATTACCTGTTCCGTGCGGTCGA
CCCCGAGCGCAGCGTGTCGCAGGCCGCGCAGGCGGCGGTGCGTGAGATCGTCGGCGCAAAGCGCGCGGACGACGTGCTCG
CGCAGGATCGCGACGCGTTGCGCGACGCGCTCGCGAAGACGATCCAGCGCGACCTCGACCGCTATCGCACGGGCCTCGTC
GTGACCGGCGTGACCGTGCAGAGCGTCGCGCCGCCCGAGCAGGTGCAGGCCGCCGTCGACGACATCGCGAAGGCGCGCCA
GGACAGCGAGGCCGCGAAGAACGCCGCGCAGGCGTATGCGAGCGAATTGCTGCCGCGGGCGCAGGGCGACGCGGCGAAGA
TGGTCGACGACGCGAAGTCGTACGCCGAGCGCGTCGTCGCGCGGGCCGAGGGCGACGCGGAGCGTTTCAAGCAGGTCTAC
GCTCAATACTCGAAAGCGCCTGCGGTGATCCGCGAGCGGATGTACCTCGAGACGATGCAGGAGATCTATTCGAACACGAC
GAAGGTGTACGTCGGCAACAAGGCGGGCAACAGCGTGCTGTATCTGCCGCTCGACAAGATCGTCGAGACGGGCCGCCAGC
GTGCGGCCGACGCGGCGAGCGCCGCCGCCGCGACGCCCGCGAGCGGCGCGCAGGCGCAAACGTCCGCCCCCGCGTTTGCC
GCGCCGGCATCGGCCGCGGCTGCCGCGAGCATGCCGCGTGCGGCGGCGCCTGCCGCCGCGAGCCCGGCGTCCGGCAGCGA
TTCGCTGCGCTCGCGCGAGGCGTTTCGCAGCCGTTCGCGCACCGACGATCTGCAGTAA

Upstream 100 bases:

>100_bases
TTCCGAACACGGGCGCTGACGGCTGCGGCCGATCAAGTTGCTCCAATCTGGTGAACAAACACAGGTGAACGACTACAACG
AGCGGAGTACCTGGCGGCGA

Downstream 100 bases:

>100_bases
CGAGGAGCGCATCACATGAACCGAATCATCGCGCTCGTCGTAGCGATCGTCATCGTCGTGCTGGCGGCCTCGTCGACGGT
GCTCGTCGTCGATCCGCGCC

Product: ftsH protease activity modulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDNGRAARVGVGIVA
GVLIAIYLGSGIFIVQDGQTGVVLRFGEYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTR
DADIVDVRFAVQYRIGSPTDYLFRAVDPERSVSQAAQAAVREIVGAKRADDVLAQDRDALRDALAKTIQRDLDRYRTGLV
VTGVTVQSVAPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVARAEGDAERFKQVY
AQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVETGRQRAADAASAAAATPASGAQAQTSAPAFA
APASAAAAASMPRAAAPAAASPASGSDSLRSREAFRSRSRTDDLQ

Sequences:

>Translated_445_residues
MRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDNGRAARVGVGIVA
GVLIAIYLGSGIFIVQDGQTGVVLRFGEYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTR
DADIVDVRFAVQYRIGSPTDYLFRAVDPERSVSQAAQAAVREIVGAKRADDVLAQDRDALRDALAKTIQRDLDRYRTGLV
VTGVTVQSVAPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVARAEGDAERFKQVY
AQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVETGRQRAADAASAAAATPASGAQAQTSAPAFA
APASAAAAASMPRAAAPAAASPASGSDSLRSREAFRSRSRTDDLQ
>Mature_445_residues
MRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDNGRAARVGVGIVA
GVLIAIYLGSGIFIVQDGQTGVVLRFGEYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTR
DADIVDVRFAVQYRIGSPTDYLFRAVDPERSVSQAAQAAVREIVGAKRADDVLAQDRDALRDALAKTIQRDLDRYRTGLV
VTGVTVQSVAPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVARAEGDAERFKQVY
AQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVETGRQRAADAASAAAATPASGAQAQTSAPAFA
APASAAAAASMPRAAAPAAASPASGSDSLRSREAFRSRSRTDDLQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=378, Percent_Identity=33.0687830687831, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 47726; Mature: 47726

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGG
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
NNGFRPDNGRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRFGEYKGSVGDGVHWR
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCCCEEEE
LPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTRDADIVDVRFAVQYRIGSPTD
ECCCCCCCCHHHHHHHEEEEECCCCEEEEECCCHHHHHHCCCCEEEEEEEEEEECCCCHH
YLFRAVDPERSVSQAAQAAVREIVGAKRADDVLAQDRDALRDALAKTIQRDLDRYRTGLV
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VTGVTVQSVAPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKS
EECEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YAERVVARAEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVL
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
YLPLDKIVETGRQRAADAASAAAATPASGAQAQTSAPAFAAPASAAAAASMPRAAAPAAA
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
SPASGSDSLRSREAFRSRSRTDDLQ
CCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGG
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
NNGFRPDNGRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRFGEYKGSVGDGVHWR
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCCCEEEE
LPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTRDADIVDVRFAVQYRIGSPTD
ECCCCCCCCHHHHHHHEEEEECCCCEEEEECCCHHHHHHCCCCEEEEEEEEEEECCCCHH
YLFRAVDPERSVSQAAQAAVREIVGAKRADDVLAQDRDALRDALAKTIQRDLDRYRTGLV
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VTGVTVQSVAPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKS
EECEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YAERVVARAEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVL
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
YLPLDKIVETGRQRAADAASAAAATPASGAQAQTSAPAFAAPASAAAAASMPRAAAPAAA
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
SPASGSDSLRSREAFRSRSRTDDLQ
CCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]