Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 83718879

GI number: 83718879

Start: 1019634

End: 1020947

Strand: Direct

Name: envZ [H]

Synonym: BTH_I0894

Alternate gene names: 83718879

Gene position: 1019634-1020947 (Clockwise)

Preceding gene: 83721603

Following gene: 83719463

Centisome position: 26.77

GC content: 72.15

Gene sequence:

>1314_bases
ATGCGCAAACCCATTGATTCGCTGTTCGGGCGGCTCGCGCTCCTCGTCGTCGGCGTGCTGTTGTTGTCGCACTTCGCGTG
GTACTTCGCGATCCGGCTCGAGCGCAATCAGTTCCAGACACGCTATGCGGTCGAGGAGGCGGCGTTCCTCGTCGACGCGG
TGCGCCAGCACGCGGAGCGCTCGCCCGACCAGCCGCTGCCGTCGCGAGTGCGGCTCGTCGCGCCGGACAGCGGCGACGTG
CCCGACGCGAACCTGGATTTGCCGACCCCGCTCAAGCGTTTCACGGACGACCTGCGCGACCGCCTGCCGGCCGGCTCGCA
GGTGCGCATCGGCAGGCCGGGCCATCCGCCCGTGCTGTGGGTCAAGCAGCCGACCGATCGCGACTGGATCGTCGTGCCGG
TTCAGCCGCTGCGGCCGCCGCGCTCGCTCGACCGGATGGTGCTCTGGCTCGCGTTGATCTTCTCGGCCGCGGTGATGGCG
GCGCTCTTCGCCGCATGGCAGTTGCAGCAGCCGCTCAGCTCGCTCGCGCGCGCGGTCGCGCGTTTCGGCCGCGGAATGGC
GGTGCCGCCGCTGCCCGAGCGCGGGCCGCGCGAGCTGCGCCAGCTCACGCACGGCTTCAACCAGATGGTTCAGCAGGTGT
CGCGCGCGGAGAACGACCGCGCGGTGATGCTGGCGGGCGTCGCGCACGACCTGCGCACGCCGCTCGCACGGATGAGGCTG
CGCGCCGAGATGATGGACGACGCGCGGCTGCGCGACGGCGTCGTGCGCGACGTCGATTCGATGACGCACATCGTCGATCA
ATTCCTTGTGTTCGCGCACGGCGACGTCGACCGCAGCGAGGCCGTGCCCGTCGACCAGGCGTGCGAGCGGATCGCACGCA
CGTACCGCGCCGTGTCGCCGAACGCGCCCGGCGTGCGGACCGAGCTCGCGGCGGGGCCGGGCTTTCGCCTGCCGGCGGCG
ACGCTCGACCGGGTGCTGTCGAACCTGCTCGACAATGCGCACGCATACGGCGCGCCGCCCGTCGTGATCTCGACCGCGCG
CACCGCGGCGGGCTACACGCTGGCCGTCAGCGACCACGGCAAGGGCATCGCGCCGCGCGATCTCGCGGACGCGACGCGTC
CGTTCGTGCGGCTCGATCCGGCGCGCGGCGGCAACGGGCACAGCGGCCTCGGGCTCGCGATCGTCGAGCGGCTCGTGCAG
CGCACGGGTGGCACTTGCGAGATCGGCAACCGGGAAGAAGGGGGCCTGCGGGTCGCGATGACGTTTGCGTTCGACGTCGT
GCCGAAGGCGGAGCCGCAGGCGGCGGCATCCTGA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGCCGGATTCTCGAAACCGATCCGTCGACGCCGCGTTTCATCCAGACGGTGCGCGGGCGCGGCTACGTGTT
CGTGCCGAACGGCGAGGCTC

Downstream 100 bases:

>100_bases
CGCGCCGCGGCGGGACGGCGCGGGATTCGCGGCGCCCGCCGCTGCCGCGCCGCGGGCGGCGGGTCACTCGCCGAAGAGCG
TGCTGAGCGTCTCGGCGGCG

Product: osmolarity sensor protein EnvZ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPDSGDV
PDANLDLPTPLKRFTDDLRDRLPAGSQVRIGRPGHPPVLWVKQPTDRDWIVVPVQPLRPPRSLDRMVLWLALIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDVDRSEAVPVDQACERIARTYRAVSPNAPGVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVISTARTAAGYTLAVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGTCEIGNREEGGLRVAMTFAFDVVPKAEPQAAAS

Sequences:

>Translated_437_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPDSGDV
PDANLDLPTPLKRFTDDLRDRLPAGSQVRIGRPGHPPVLWVKQPTDRDWIVVPVQPLRPPRSLDRMVLWLALIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDVDRSEAVPVDQACERIARTYRAVSPNAPGVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVISTARTAAGYTLAVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGTCEIGNREEGGLRVAMTFAFDVVPKAEPQAAAS
>Mature_437_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPDSGDV
PDANLDLPTPLKRFTDDLRDRLPAGSQVRIGRPGHPPVLWVKQPTDRDWIVVPVQPLRPPRSLDRMVLWLALIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDVDRSEAVPVDQACERIARTYRAVSPNAPGVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVISTARTAAGYTLAVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGTCEIGNREEGGLRVAMTFAFDVVPKAEPQAAAS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=431, Percent_Identity=29.0023201856148, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787894, Length=260, Percent_Identity=31.9230769230769, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=28.0898876404494, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=324, Percent_Identity=25.6172839506173, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=29.2372881355932, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=26.9360269360269, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=28.2945736434109, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=267, Percent_Identity=28.8389513108614, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47877; Mature: 47877

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPDSGDVPDANLDLPTPLKRFTDDLRDRLPAGSQVRIGRPGHPPVLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEE
VKQPTDRDWIVVPVQPLRPPRSLDRMVLWLALIFSAAVMAALFAAWQLQQPLSSLARAVA
EECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDVDRSEAVPVDQACERIARTYRAVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAPGVRTELAAGPGFRLPAATLDRVLSNLLDNAHAYGAPPVVISTARTAAGYTLAVSDHG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCC
KGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRTGGTCEIGNREEGGLRVAM
CCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEE
TFAFDVVPKAEPQAAAS
EEHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPDSGDVPDANLDLPTPLKRFTDDLRDRLPAGSQVRIGRPGHPPVLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEE
VKQPTDRDWIVVPVQPLRPPRSLDRMVLWLALIFSAAVMAALFAAWQLQQPLSSLARAVA
EECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDVDRSEAVPVDQACERIARTYRAVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAPGVRTELAAGPGFRLPAATLDRVLSNLLDNAHAYGAPPVVISTARTAAGYTLAVSDHG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCC
KGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRTGGTCEIGNREEGGLRVAM
CCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEE
TFAFDVVPKAEPQAAAS
EEHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]