Click here to switch to the map view.

The map label for this gene is fsr [H]

Identifier: 83718758

GI number: 83718758

Start: 2994911

End: 2996173

Strand: Direct

Name: fsr [H]

Synonym: BTH_I2630

Alternate gene names: 83718758

Gene position: 2994911-2996173 (Clockwise)

Preceding gene: 83720158

Following gene: 83721247

Centisome position: 78.62

GC content: 67.06

Gene sequence:

>1263_bases
ATGGAAACCAGCCTCGACAACCGCCCGTCCATTGCCCGTCCCGACACCTCGCCCGCACCGGCCGCGCCGGCCGCCGCCGT
CTCTCGCACCGTCTACCCGGTGCTCGGCGCGATCAGCTTCTCGCATCTGCTCAACGACATGATCCAGTCGCTGATCCTCG
CGATCTATCCGATGCTGAAATCGGAATTCTCGCTGTCGTTCGCGCAGATCGGCCTCATCACGCTCACGTACCAGATCACC
GCGTCGCTGCTGCAGCCCGTGATCGGCTTGTACACGGACAAGCGCCCGCAGCCGTTCTCGCTGCCCGTCGGCATGGGCTT
CACGCTCACGGGCCTGCTGCTGATGGCGTTCGCGCCGACGTTCCCGTTCCTGCTCGTCGCGGCCGCGCTCGTCGGCTGCG
GCTCGTCGGTGTTTCATCCGGAATCGTCGCGCGTCGCGCGGATGGCGTCGGGCGGCCGGCACGGGCTCGCGCAGTCGCTG
TTCCAGGTCGGCGGCAACGCCGGCTCGTCGCTCGGGCCGCTGCTCGCCGCGCTGATCGTGATCCCGCACGGCCAGCGCAG
CATCGCGTGGTTCTCGGCCGCGGCGCTCGTCGCGATCTTCGTGCTCGTTCAGATCGGCCGCTGGTATCAGCGCCATCCGG
CCGCGCGGAAAAAGGCCGCGCACGCCGCGCATCCGACGCTGTCGCGCCGCCAGATCGGGCTCGCGCTCGGCGTGCTCGTG
ATGCTCGTGTTCTCGAAGTACTTCTATCTCGCGAGCATCAACAGCTATTTCACGTTCTATCTGATCGACAGGTTCCACCT
GTCGGTGCAGGCCGCGCAGATCCATCTGTTCGTGTTCCTCGCGGCCGTCGCGGCGGGCACGATCATCGGCGGGCCGGTCG
GCGACCGGATCGGACGCAAGTACGTGATCTGGACGTCGATCCTCGGCGTCGCGCCGTTCACGCTGATGCTGCCGTATGCG
AATCTGTTCTGGACCACGGTGCTGACCATCGTGATCGGCGTCGTGCTCGCGTCGGCGTTCGCGGCGATCATCGTCTACGG
CCAGGAGCTGATTCCGGGCAAGGTCGGGACGGTTGCCGGGCTGTTTTTCGGGCTGTCGTTCGGCCTCGGCGGCGTCGGCG
CGGCGGTGCTCGGCCAGCTCGCCGACGCGACGAGCATCGCGTTCGTCTACAAGGTCTGTTCGTTCCTGCCGCTGATCGGC
GTGTTGACGGTGTTTCTGCCGAACCTCGAGGGCAGGAAGACGCTCGGCAAGCAAGGCGGCTGA

Upstream 100 bases:

>100_bases
TTGCCGATGAGCCACATTACACTTCGTTGACCCATCAAAGAAAAACACGTGCAGTGCCCTTTCGAGCACGCAGCGCCCCT
TCCGAGACACTCGCATTCCT

Downstream 100 bases:

>100_bases
CGGGGCGGCGCGCGCGGCGCAACCGTCAACCGCTCGCGGCCGACGCGGCCGCGGCGGTCCTCCGTATGGTCGGTATGGTC
CGGATGATCCGTGCGGTCCG

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
METSLDNRPSIARPDTSPAPAAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQIT
ASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSL
FQVGGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYQRHPAARKKAAHAAHPTLSRRQIGLALGVLV
MLVFSKYFYLASINSYFTFYLIDRFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYA
NLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIG
VLTVFLPNLEGRKTLGKQGG

Sequences:

>Translated_420_residues
METSLDNRPSIARPDTSPAPAAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQIT
ASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSL
FQVGGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYQRHPAARKKAAHAAHPTLSRRQIGLALGVLV
MLVFSKYFYLASINSYFTFYLIDRFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYA
NLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIG
VLTVFLPNLEGRKTLGKQGG
>Mature_420_residues
METSLDNRPSIARPDTSPAPAAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQIT
ASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSL
FQVGGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYQRHPAARKKAAHAAHPTLSRRQIGLALGVLV
MLVFSKYFYLASINSYFTFYLIDRFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYA
NLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIG
VLTVFLPNLEGRKTLGKQGG

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=398, Percent_Identity=66.5829145728643, Blast_Score=500, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44480; Mature: 44480

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSLDNRPSIARPDTSPAPAAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLK
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEFSLSFAQIGLITLTYQITASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNAGSSLGPLLAALIV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
IPHGQRSIAWFSAAALVAIFVLVQIGRWYQRHPAARKKAAHAAHPTLSRRQIGLALGVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
MLVFSKYFYLASINSYFTFYLIDRFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCE
YVIWTSILGVAPFTLMLPYANLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAG
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIGVLTVFLPNLEGRKTLGKQGG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
>Mature Secondary Structure
METSLDNRPSIARPDTSPAPAAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLK
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEFSLSFAQIGLITLTYQITASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNAGSSLGPLLAALIV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
IPHGQRSIAWFSAAALVAIFVLVQIGRWYQRHPAARKKAAHAAHPTLSRRQIGLALGVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
MLVFSKYFYLASINSYFTFYLIDRFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCE
YVIWTSILGVAPFTLMLPYANLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAG
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIGVLTVFLPNLEGRKTLGKQGG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]