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The map label for this gene is aceK [H]

Identifier: 83718628

GI number: 83718628

Start: 382968

End: 384779

Strand: Reverse

Name: aceK [H]

Synonym: BTH_I0346

Alternate gene names: 83718628

Gene position: 384779-382968 (Counterclockwise)

Preceding gene: 83718821

Following gene: 83720993

Centisome position: 10.1

GC content: 63.96

Gene sequence:

>1812_bases
ATGAATCACTTTCCCAAACTGCTGTCCTCGCAGATCGGCTTCGACGTCGCGCAGACGATCCTCGAGAACTTCGATCGCCA
CTACCGGATCTTCCGCGAGGCGGCCGTCGAAGCGAAGGACCTGTTCGAGCGCTCGGACTGGCACGGGCTGCAGCGGCTCG
CGCGCGAGCGCATCACGTCGTACGACGACCGCGTGCGCGAGTGCGTCGAGCTGCTCGAGGACGAGTACGACGCGGAGAAC
ATCGACCACGACGTCTGGCCGCAGATCAAGCTGCATTACATCGGCCTCCTGACGTCGCACCGCCAGCCCGAATGCGCGGA
AACGTTCTTCAATTCGGTGTGCTGCAAGATCCTGCATCGCGCGTACTTCAACAACGATTTCATCTTCGTGCGCCCGGCGA
TCTCGACCGAATACATCGAGAACGACGAGCCCGCCGCGAAGCCGACGTACCGCGCGTACTATCCGGGCAGCGAGGGGCTC
GCCGCGACGCTCGAGCGGATCGTCACGAACTTCCAGCTCAACCCGCCGTTCGAGGATCTCGAGCGCGACATCGCGTGCAT
CATGCAGGCGATCCACGACGAGTTCGGCGCGTTCGACGAAGCGGTGAATTTCCAGATCCACGTGCTCTCGTCGCTGTTCT
ACCGGAACAAGACCGCGTACATCGTCGGGCGCATCATCAACGGCGACCGCGTGCTGCCGTTCGCGGTGCCGATCCGCCAC
GCGCGCGCGGGCGTTCTCGCGCTCGACACGGTGCTCCTGCGGCGCGACCAGCTGAAGATCATCTTCAGCTTCTCGCACTC
GTACTTCCTCGTCGACATGAACGTGCCGTCCGCGTACGTGCAGTTCCTGCGCTCGATCATGCCGGGCAAGCCGAAGGCGG
AGATCTACACGTCGGTGGGCCTGCAGAAGCAGGGCAAGAACCTGTTCTACCGCGATCTGCTGCATCACCTGTCGCATTCG
AGCGACCGCTTCATCATCGCGCCCGGCATCAAGGGCCTCGTGATGCTCGTGTTCACGCTGCCGTCGTTCCCGTACGTGTT
CAAGATGATCAAGGATCACTTCCCGCCGCCGAAGGAAACGACGCGCGAGCAGATCATGGACAAATACCTGCTCGTCAAGC
GCCACGACCGCCTCGGCCGGATGGCGGACACGCTCGAATACTCGAGCGTCGCGCTGCCGCTCGCGCGGCTCGACGACGCG
CTCGTGCGCGAGCTCGAAAAGGAAGTGCCGTCGCTCATCGAATACGAGGGCGACAGCCTCGTCATCAAGCACCTGTACAT
CGAGCGCCGGATGGTGCCGCTCAACCTGTATCTGCAAAACGGCAGCGACGCCGAGATCGAGCACGGCGTGCGCGAATACG
GCAACGCGGTGAAGGAACTGATCCAGGCGAACATCTTCCCCGGCGACATGCTGTACAAGAACTTCGGCGTGACGCGCCAC
GGGCGCGTCGTGTTCTACGACTACGACGAGATCGAATACCTGACCGACTGCAACGTGCGCCGCGTGCCGCCGCCGCGCAA
CGACGAAGACGAGATGTCGGGCGAGCCGTGGTACACGGTCGGCCCGCACGACATCTTCCCAGAAACCTACGCGCCGTTCC
TGCTTGGCGACCCGCGCGTGCGCGAGCACTTCCTCGCGCATCACGCGGATTTCTTCGATCCGCAGCTCTGGCAGGACAGC
AAGGACCGCCTGCTGCGCGGCGAGCTGCCCGATTTCTTCGCCTACGAGCCGGCGCTGCGCTTTTGCCTCCGCTATCCGGA
GCGCTTCGCGCCGGGCGACGCGGCCGAAGACGGCAAGCGCGCCGCCGCGTGA

Upstream 100 bases:

>100_bases
GGCCGCACCGGCCGCCTGCGCCGAATCGCCCTGCAATGGCTAAAGCGCGCCCGCCCGGCGCTAAAATGGCGTGAGCTTTC
CGCCCGTGAGCCCGCGCACG

Downstream 100 bases:

>100_bases
GCGCCGCCGCTCGCCCGCGTGCGAACGCTCTTTTTTTCATCCCACGGAACCTACACTTGAGATGAACACGAACGACCATC
CGCTCTCCCATCTGTTCGAC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRH
ARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKETTREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGDSLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKRAAA

Sequences:

>Translated_603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRH
ARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKETTREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGDSLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKRAAA
>Mature_603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRH
ARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKETTREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGDSLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKRAAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=572, Percent_Identity=41.7832167832168, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 70048; Mature: 70048

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITS
CCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
YDDRVRECVELLEDEYDAENIDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
AYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRH
HHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHHHH
ARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVG
HHCCHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHH
TREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRH
EEHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCHHCCCCCCEECCCHHCCCCCCCCCCCCCHHH
REHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKR
HHHHHHHHCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCCC
AAA
CCC
>Mature Secondary Structure
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITS
CCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
YDDRVRECVELLEDEYDAENIDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
AYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRH
HHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHHHH
ARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVG
HHCCHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHH
TREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRH
EEHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCHHCCCCCCEECCCHHCCCCCCCCCCCCCHHH
REHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKR
HHHHHHHHCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCCC
AAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA