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The map label for this gene is nadC [H]

Identifier: 83718617

GI number: 83718617

Start: 895395

End: 896279

Strand: Direct

Name: nadC [H]

Synonym: BTH_I0777

Alternate gene names: 83718617

Gene position: 895395-896279 (Clockwise)

Preceding gene: 83720822

Following gene: 83718454

Centisome position: 23.51

GC content: 69.94

Gene sequence:

>885_bases
ATGACGAACGGCGCGATGTCTCCGCTTTTCGCTGAAATCTCGCGCGAATACGGCGCCGCGTTCGACGCGGCGATCGCGCG
CAACGTGGCCGATGCGCTCGCCGAGGACGTCGGCGGCGGCGATCAGACCGGGCGCCTCGTGCCGGACGGCGCGCCGCGCC
GCGCGCGCGTGATCGTGCGCGAGGAGGCCGTGCTGTGCGGCGTGCCGTGGTTCGACGCGGTGGTGCGCGCGGTCGATCCG
TCGATCGAGGTCGACTGGCGCTATCGCGAAGGCGACCGGATGACGGCGGATTCGACCGTCTGCGAACTGCGCGGCCCCGC
GCGTTCGTTGCTGACGGCCGAGCGCAACGCGCTCAACTTCCTGCAGCTGCTGTCGGGCGTCGCGACCGCGACGCGCCGCT
ACGTCGACCGGATCGCCGATACGCGCACGCGCATTCTCGACACGCGCAAGACGCTGCCGGGCCTGCGGCTCGCGCAGAAG
TACGCGGTGCGCGTGGGCGGCGGCGCGAACCAGCGGCTCGCGCTCTACGCGGGCATCCTGATCAAGGAGAATCACATCGC
GGCGGCGGGCGGCGTCGGCGAGGCGCTCGACGCGGCGTTCGCGTTGAACGCCGCCGTGCCGGTGCAGATCGAGGTCGAAA
CGCTCGACCAGCTTCGCACGGCGCTCGCGCACGGTGCGCGATCGGTGCTGCTCGACAATTTCACGCTCGATATGATGCGC
GACGCGGTGCGCATCACCGAGGGCCGCGCGGTGCTCGAGGTGTCGGGCGGCGTGAATTTCGATACGGTGCGTGCGATCGC
CGAGACGGGCGTCGATCGAATCTCGATCGGCGCGCTGACGAAGGACGTGCGCGCGATCGATTATTCGATGCGTATCGTCG
AGTGA

Upstream 100 bases:

>100_bases
TCGACCGGATGCTCGATTTCGCCGCGCGCCACAAGCAGCGCGTGCAGGCGAGCGGCGATCTGCTGCGCGATCAGCAACTC
TTCGCGAACGTGGGGGCGGC

Downstream 100 bases:

>100_bases
CGTGACGGGCGCGCGCGTGCATCGCGCAGGCGTGCGCTCGGGGCAGAGAAGCGGGCCGAAGACATAGGCCAAAGGCATGA
GCCAAAGGCGAGGCCGCCGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTNGAMSPLFAEISREYGAAFDAAIARNVADALAEDVGGGDQTGRLVPDGAPRRARVIVREEAVLCGVPWFDAVVRAVDP
SIEVDWRYREGDRMTADSTVCELRGPARSLLTAERNALNFLQLLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQK
YAVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNAAVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
DAVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMRIVE

Sequences:

>Translated_294_residues
MTNGAMSPLFAEISREYGAAFDAAIARNVADALAEDVGGGDQTGRLVPDGAPRRARVIVREEAVLCGVPWFDAVVRAVDP
SIEVDWRYREGDRMTADSTVCELRGPARSLLTAERNALNFLQLLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQK
YAVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNAAVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
DAVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMRIVE
>Mature_293_residues
TNGAMSPLFAEISREYGAAFDAAIARNVADALAEDVGGGDQTGRLVPDGAPRRARVIVREEAVLCGVPWFDAVVRAVDPS
IEVDWRYREGDRMTADSTVCELRGPARSLLTAERNALNFLQLLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQKY
AVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNAAVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMRD
AVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMRIVE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=266, Percent_Identity=34.9624060150376, Blast_Score=141, Evalue=7e-34,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50.7407407407407, Blast_Score=238, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6321162, Length=293, Percent_Identity=31.0580204778157, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31647; Mature: 31516

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGAMSPLFAEISREYGAAFDAAIARNVADALAEDVGGGDQTGRLVPDGAPRRARVIVR
CCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
EEAVLCGVPWFDAVVRAVDPSIEVDWRYREGDRMTADSTVCELRGPARSLLTAERNALNF
ECEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
LQLLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEEEEEEEE
IKENHIAAAGGVGEALDAAFALNAAVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
EECCCEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
DAVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMRIVE
HHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TNGAMSPLFAEISREYGAAFDAAIARNVADALAEDVGGGDQTGRLVPDGAPRRARVIVR
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
EEAVLCGVPWFDAVVRAVDPSIEVDWRYREGDRMTADSTVCELRGPARSLLTAERNALNF
ECEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
LQLLSGVATATRRYVDRIADTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEEEEEEEE
IKENHIAAAGGVGEALDAAFALNAAVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
EECCCEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
DAVRITEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRAIDYSMRIVE
HHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]