Click here to switch to the map view.

The map label for this gene is fucA [C]

Identifier: 83718603

GI number: 83718603

Start: 584140

End: 584916

Strand: Direct

Name: fucA [C]

Synonym: BTH_I0518

Alternate gene names: 83718603

Gene position: 584140-584916 (Clockwise)

Preceding gene: 83718548

Following gene: 83721534

Centisome position: 15.33

GC content: 68.08

Gene sequence:

>777_bases
GTGACGATTCAAGCGCCGAATCAACCGTTTGCCCGCCCGCCGCGCTTTGCCGACGCGGAGTGGCAGGCGCGCGTCCGGCT
GGCGGCCGCGTACCGGATCTTCGATCACCTCGGCTGGAGCGAGCTGATCTACAACCACATCTCGCTGCGCGTGCCGGGCG
AAGACACGCATTTCCTGATCAACCCGTTCGGGCTGCATTACCGCGAGGTGTGCGCATCGAATCTCGTGAAGGTCGACGTC
GAAGGGCGCCCGGTCGGCCACTCCGACTGGCCGATCAATCCGGCCGGCTTCACGTTTCATGCGGCGATTCACCTGGCGCT
GCCCGACGCGCACTGCGTGATGCACGTGCACACGACGCCGACGATGGCCGTGTGCGCGTCGCGGCGCGGGCTGTCGTACT
CCAATTTCTATGCGGCGCAACTGCATGGGCGCGTCGCGCATCACGATTTCGAGGGCATCACCGTGCGGCCGGACGAAGGC
CGGCGGATCGTCGACAGCGCGGCGGGGCGTCCGGTGCTGCTGCTGCGCAATCATGGGCCCGTCGCGATCGGCCGCACGCT
CGCGCACGCGTTCTCGTTGATGTGGCTGCTTCATCGCGCGTGCGAAGTGCAGGTCGCGACGCAGGCGCTCGGCGAGCCGC
TCGAGATCGACGCGCCGATCCTGGAGGCGTGCGCGCGCGATTCGCTGAACCTCGATCCGCGCTACGGCGCGGGGCAGGAT
GCGTTCGACGCGCTGCAGCGGATCGTCGACCGGGTCGATCCGGGTTACCGGAGCTGA

Upstream 100 bases:

>100_bases
CGCTGCTGTTCCTGTAGCGCAGGCCAGTTGCCGGGCTTGCGAGCGCCGCGCGTTCGATGCGTGCGGCGCGCGCATCGATA
TCATTCGACGAGGAGCGCAC

Downstream 100 bases:

>100_bases
ATGCGGCGGCGATTGTTCCGATCAAAATCGGTCGCCGGATTGACTTCAAATATTAAGAATCAATTGATCCGGCGCGTCCG
CATTCGGAATTGAAATTTGA

Product: aldolase II superfamily protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTIQAPNQPFARPPRFADAEWQARVRLAAAYRIFDHLGWSELIYNHISLRVPGEDTHFLINPFGLHYREVCASNLVKVDV
EGRPVGHSDWPINPAGFTFHAAIHLALPDAHCVMHVHTTPTMAVCASRRGLSYSNFYAAQLHGRVAHHDFEGITVRPDEG
RRIVDSAAGRPVLLLRNHGPVAIGRTLAHAFSLMWLLHRACEVQVATQALGEPLEIDAPILEACARDSLNLDPRYGAGQD
AFDALQRIVDRVDPGYRS

Sequences:

>Translated_258_residues
MTIQAPNQPFARPPRFADAEWQARVRLAAAYRIFDHLGWSELIYNHISLRVPGEDTHFLINPFGLHYREVCASNLVKVDV
EGRPVGHSDWPINPAGFTFHAAIHLALPDAHCVMHVHTTPTMAVCASRRGLSYSNFYAAQLHGRVAHHDFEGITVRPDEG
RRIVDSAAGRPVLLLRNHGPVAIGRTLAHAFSLMWLLHRACEVQVATQALGEPLEIDAPILEACARDSLNLDPRYGAGQD
AFDALQRIVDRVDPGYRS
>Mature_257_residues
TIQAPNQPFARPPRFADAEWQARVRLAAAYRIFDHLGWSELIYNHISLRVPGEDTHFLINPFGLHYREVCASNLVKVDVE
GRPVGHSDWPINPAGFTFHAAIHLALPDAHCVMHVHTTPTMAVCASRRGLSYSNFYAAQLHGRVAHHDFEGITVRPDEGR
RIVDSAAGRPVLLLRNHGPVAIGRTLAHAFSLMWLLHRACEVQVATQALGEPLEIDAPILEACARDSLNLDPRYGAGQDA
FDALQRIVDRVDPGYRS

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826323, Length=257, Percent_Identity=40.8560311284047, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI29826325, Length=257, Percent_Identity=40.8560311284047, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI29826321, Length=257, Percent_Identity=40.8560311284047, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI29826319, Length=257, Percent_Identity=40.8560311284047, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI9257190, Length=261, Percent_Identity=34.8659003831418, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI89276787, Length=260, Percent_Identity=35, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI297307158, Length=261, Percent_Identity=34.8659003831418, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI9257192, Length=261, Percent_Identity=34.8659003831418, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI297307160, Length=260, Percent_Identity=35, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI9951927, Length=269, Percent_Identity=34.2007434944238, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI62912453, Length=269, Percent_Identity=34.2007434944238, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI9943848, Length=269, Percent_Identity=34.2007434944238, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI115533216, Length=190, Percent_Identity=39.4736842105263, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI115533218, Length=209, Percent_Identity=37.3205741626794, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71989541, Length=193, Percent_Identity=35.7512953367876, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71989544, Length=193, Percent_Identity=35.7512953367876, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71989560, Length=193, Percent_Identity=35.7512953367876, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71989550, Length=193, Percent_Identity=35.7512953367876, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71989555, Length=193, Percent_Identity=35.7512953367876, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281363755, Length=281, Percent_Identity=27.7580071174377, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281363751, Length=281, Percent_Identity=27.7580071174377, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24655690, Length=281, Percent_Identity=27.7580071174377, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24655685, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281363761, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281363759, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281363753, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281363763, Length=281, Percent_Identity=27.7580071174377, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363757, Length=281, Percent_Identity=27.7580071174377, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136738, Length=281, Percent_Identity=27.7580071174377, Blast_Score=110, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28681; Mature: 28550

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQAPNQPFARPPRFADAEWQARVRLAAAYRIFDHLGWSELIYNHISLRVPGEDTHFLI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCEEEE
NPFGLHYREVCASNLVKVDVEGRPVGHSDWPINPAGFTFHAAIHLALPDAHCVMHVHTTP
CCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCC
TMAVCASRRGLSYSNFYAAQLHGRVAHHDFEGITVRPDEGRRIVDSAAGRPVLLLRNHGP
HHHHHHHCCCCCHHHEEHHHHHCCHHCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCC
VAIGRTLAHAFSLMWLLHRACEVQVATQALGEPLEIDAPILEACARDSLNLDPRYGAGQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCH
AFDALQRIVDRVDPGYRS
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TIQAPNQPFARPPRFADAEWQARVRLAAAYRIFDHLGWSELIYNHISLRVPGEDTHFLI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCEEEE
NPFGLHYREVCASNLVKVDVEGRPVGHSDWPINPAGFTFHAAIHLALPDAHCVMHVHTTP
CCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCC
TMAVCASRRGLSYSNFYAAQLHGRVAHHDFEGITVRPDEGRRIVDSAAGRPVLLLRNHGP
HHHHHHHCCCCCHHHEEHHHHHCCHHCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCC
VAIGRTLAHAFSLMWLLHRACEVQVATQALGEPLEIDAPILEACARDSLNLDPRYGAGQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCH
AFDALQRIVDRVDPGYRS
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]