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The map label for this gene is pth

Identifier: 83595076

GI number: 83595076

Start: 4295478

End: 4296209

Strand: Direct

Name: pth

Synonym: Rru_A3747

Alternate gene names: 83595076

Gene position: 4295478-4296209 (Clockwise)

Preceding gene: 83595075

Following gene: 83595077

Centisome position: 98.68

GC content: 67.9

Gene sequence:

>732_bases
ATGAAGCTTGTGGTGGGACTGGGCAATCCCGGCCCCCGCTATGCGGGAAATCGCCATAACGTCGGCTTCATGGCCGTCGC
CGCCTTGGCGCGACGGCACGGAATCGGACCCTTCCGGCGCAAGTTCCAGGCCCAGGTCGCCGACGGCCAGATCGCCGGCG
CCCGCCTGCTGCTGCTGGCGCCCGAGACGTTCATGAACGCCTCGGGCCAGGCGGTGGGGGAAGCCGCCCGCTTTCACAAG
ATCGCCCCCGAAGACATCATCGTGCTTCACGACGAGCTTGATCTCGCCCCGGGCAAGATCAAGGTCAAGCAAGGTGGCGG
CGCCGGCGGTCATAACGGCATCCGCGATATCGAGGCCCACCTTGGCCCGGCCTTCTGGCGGGTGCGCCTGGGCATCGGCC
ATCCCGGCCACAAGGACCGGGTTCTGACTTACGTGCTGGGCGATTTCGCCAAGGCCGAGGAAGACTGGCTGGCGCCGATG
CTTGACGCGGTGGCCGATCACTTCGCCCTGATGCTGGAAGGCCGGCCGGCCGATTTCATGTCCAAAGTGGCGGCCCAGAC
CCGGCCCGCCGAAAAGGCCAAGCCGCTAGCGACGGCCAAACCCAAAGAGGGGGAGGCGCGCACGTCCGGGGGATCGGTGG
CCGAGGTCGGCGCCCCACCCCCCTCTCCTACGGGTCTTGCCGCAGCGCTCGCCGAGGCCCTCGACCGTAAAAGCCAGAAA
GGGAACGGCTGA

Upstream 100 bases:

>100_bases
TCCGTCGGGCTTGAAGTCTGAAGAAGCCGCCGCCGGGGAAGCCGCCGCCGCCGCCGCCACTCCCGCGGCGTAACGTCCTC
TGCCGGAAGGATCCGTTGCG

Downstream 100 bases:

>100_bases
GCCATGGGATTCAAATGCGGCATCGTTGGTCTGCCCAACGTCGGCAAATCGACTCTTTTCAACGCCCTGACCTCGACCGC
CGCCGCCCAGGCGGCCAATT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKLVVGLGNPGPRYAGNRHNVGFMAVAALARRHGIGPFRRKFQAQVADGQIAGARLLLLAPETFMNASGQAVGEAARFHK
IAPEDIIVLHDELDLAPGKIKVKQGGGAGGHNGIRDIEAHLGPAFWRVRLGIGHPGHKDRVLTYVLGDFAKAEEDWLAPM
LDAVADHFALMLEGRPADFMSKVAAQTRPAEKAKPLATAKPKEGEARTSGGSVAEVGAPPPSPTGLAAALAEALDRKSQK
GNG

Sequences:

>Translated_243_residues
MKLVVGLGNPGPRYAGNRHNVGFMAVAALARRHGIGPFRRKFQAQVADGQIAGARLLLLAPETFMNASGQAVGEAARFHK
IAPEDIIVLHDELDLAPGKIKVKQGGGAGGHNGIRDIEAHLGPAFWRVRLGIGHPGHKDRVLTYVLGDFAKAEEDWLAPM
LDAVADHFALMLEGRPADFMSKVAAQTRPAEKAKPLATAKPKEGEARTSGGSVAEVGAPPPSPTGLAAALAEALDRKSQK
GNG
>Mature_243_residues
MKLVVGLGNPGPRYAGNRHNVGFMAVAALARRHGIGPFRRKFQAQVADGQIAGARLLLLAPETFMNASGQAVGEAARFHK
IAPEDIIVLHDELDLAPGKIKVKQGGGAGGHNGIRDIEAHLGPAFWRVRLGIGHPGHKDRVLTYVLGDFAKAEEDWLAPM
LDAVADHFALMLEGRPADFMSKVAAQTRPAEKAKPLATAKPKEGEARTSGGSVAEVGAPPPSPTGLAAALAEALDRKSQK
GNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=40.4761904761905, Blast_Score=114, Evalue=7e-26,
Organism=Escherichia coli, GI1787455, Length=169, Percent_Identity=47.3372781065089, Blast_Score=120, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_RHORT (Q2RMV4)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428828.1
- ProteinModelPortal:   Q2RMV4
- SMR:   Q2RMV4
- STRING:   Q2RMV4
- GeneID:   3837204
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3747
- NMPDR:   fig|1085.1.peg.1167
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   HIRERSQ
- PhylomeDB:   Q2RMV4
- ProtClustDB:   PRK05426
- BioCyc:   RRUB269796:RRU_A3747-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 25513; Mature: 25513

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVGLGNPGPRYAGNRHNVGFMAVAALARRHGIGPFRRKFQAQVADGQIAGARLLLLA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEC
PETFMNASGQAVGEAARFHKIAPEDIIVLHDELDLAPGKIKVKQGGGAGGHNGIRDIEAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHH
LGPAFWRVRLGIGHPGHKDRVLTYVLGDFAKAEEDWLAPMLDAVADHFALMLEGRPADFM
HCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
SKVAAQTRPAEKAKPLATAKPKEGEARTSGGSVAEVGAPPPSPTGLAAALAEALDRKSQK
HHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCC
GNG
CCC
>Mature Secondary Structure
MKLVVGLGNPGPRYAGNRHNVGFMAVAALARRHGIGPFRRKFQAQVADGQIAGARLLLLA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEC
PETFMNASGQAVGEAARFHKIAPEDIIVLHDELDLAPGKIKVKQGGGAGGHNGIRDIEAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHH
LGPAFWRVRLGIGHPGHKDRVLTYVLGDFAKAEEDWLAPMLDAVADHFALMLEGRPADFM
HCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
SKVAAQTRPAEKAKPLATAKPKEGEARTSGGSVAEVGAPPPSPTGLAAALAEALDRKSQK
HHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCC
GNG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA