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The map label for this gene is hisE

Identifier: 83594922

GI number: 83594922

Start: 4135990

End: 4136343

Strand: Reverse

Name: hisE

Synonym: Rru_A3593

Alternate gene names: 83594922

Gene position: 4136343-4135990 (Counterclockwise)

Preceding gene: 83594923

Following gene: 83594921

Centisome position: 95.03

GC content: 68.36

Gene sequence:

>354_bases
ATGACCGATATCCCCCCCGCCGTCTCCCCCCCGCCCGGTCCCGAGATCATCGATGCCCTGGCGGCGGTGATCGCCAGCCG
CCAGGGGGCCGATCCCGCCACCTCCTATACCGCCAAGCTGTTTGGCCGGGGCCGGGGCAAGATCGTGCAGAAATTCGGCG
AGGAGGCCTTCGAGGTCGGCGTCGCCGCCCTGGTGGAAAGCCCCGAGCAGGTGGTCGCCGAAAGCGCCGATGTGCTTTAT
CACCTGATGGTGCTGTGGGCCGATGTCGGGGTGACCCCCGATCGGGTCTGGGCCGAATTGGCCCGCCGCTTCGGCACCTC
GGGCATCGACGAGAAAGCCGCCCGCAAGAAGTGA

Upstream 100 bases:

>100_bases
GCGGCCGGACTCCCCATGCGGCTTTAGGGCGGCACGCGGAACAGCGGCTTCGCCCGTCGCCGCCATAACGCCGGCTCCCC
ATTCAAACGGAAGATCGCCG

Downstream 100 bases:

>100_bases
CCCTGTCTTTCCGGAGCAGTCCCCATGGCCTATGACGACAGCAATATCTTCGCCCGCATCCTGCGCGGGGAAATCCCCTG
CGATAAGGTTTTCGAAGACG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTDIPPAVSPPPGPEIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAESADVLY
HLMVLWADVGVTPDRVWAELARRFGTSGIDEKAARKK

Sequences:

>Translated_117_residues
MTDIPPAVSPPPGPEIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAESADVLY
HLMVLWADVGVTPDRVWAELARRFGTSGIDEKAARKK
>Mature_116_residues
TDIPPAVSPPPGPEIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAESADVLYH
LMVLWADVGVTPDRVWAELARRFGTSGIDEKAARKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=84, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_RHORT (Q2RNA8)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428674.1
- ProteinModelPortal:   Q2RNA8
- SMR:   Q2RNA8
- STRING:   Q2RNA8
- GeneID:   3837049
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3593
- NMPDR:   fig|1085.1.peg.1904
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   WADADLE
- ProtClustDB:   PRK00400
- BioCyc:   RRUB269796:RRU_A3593-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12431; Mature: 12300

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIPPAVSPPPGPEIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVG
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VAALVESPEQVVAESADVLYHLMVLWADVGVTPDRVWAELARRFGTSGIDEKAARKK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure 
TDIPPAVSPPPGPEIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVG
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VAALVESPEQVVAESADVLYHLMVLWADVGVTPDRVWAELARRFGTSGIDEKAARKK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA