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The map label for this gene is acsA [H]

Identifier: 83594904

GI number: 83594904

Start: 4118508

End: 4120448

Strand: Direct

Name: acsA [H]

Synonym: Rru_A3575

Alternate gene names: 83594904

Gene position: 4118508-4120448 (Clockwise)

Preceding gene: 83594903

Following gene: 83594905

Centisome position: 94.62

GC content: 63.68

Gene sequence:

>1941_bases
ATGTCTGAGTCCGTTCTGGTTCCGGTGCCCGAAGCCATCGCCAAAGCCGCCTTGGTCAACGAGGCGCAATACCTTGATCT
TTACAAGTCCTCCATCGCCGACCCCGACGCCTTTTGGGCCGAGCATGGCAAGCGCATCGACTGGATCAAACCCTTTACCG
CGGTGAAGGATGTTTCCTTTGATCCCCACGACGTGCATATCCGCTGGTTCCACGACGGCACGCTCAACGTGTCGGTCAAC
TGCCTGGACCGTCACCTGGAAACCCGGGGCGACCAGACCGCCATCCTGTGGGAGGGCGACGACCCCAAGGACGACGCCCG
CATCACCTACCGCGATCTTTACGAGCGGGTGTGCAAGCTGGCCAACGCCTTCCGCGAGTTGGGCGTCAAAAAGGGCGACC
GCGTCTGCATTTATCTGCCGATGATCCCCGAGGCGGCGGTGGCGATGCTGGCCTGCGCCCGCATCGGCGCCGTTCATTCC
ATCGTGTTCGGCGGTTTCTCGCCCGATAGCCTGGCCAATCGCATCCAGGATTCCGAATGCACCCTGGTCATCACCTCCGA
CGAGGGTCTGCGCGGCGGCCGCAAGGTGGCGCTGAAAAAGAACGTCGACACCGCCTTGGAGCATTGCCCGAGCGTCAAGA
CGGTGGTGGTGGTCAAGCGCACCGGCGGCGCCATTGACACCGTCGAAGGCCGCGATGTCTGGTACCACGAGATCACCGCC
AACCAGCCCGCCGAATGCCAGCCCGAGGAAATGAACGCCGAGGATCCGCTGTTCATCCTGTACACCTCGGGCTCGACCGG
CAAGCCCAAGGGCGTGCTGCATACCTCAGGCGGCTATCTGGTCTATGTGTCGATGACCCATGAATACGTCTTCGACTACA
AGGACGGCGAGGTTTACTGGTGCACGGCCGATGTCGGCTGGGTGACCGGCCACAGCTATATCGTTTACGGGCCGCTGGCC
AATGGCGCCATCAGCCTGATGTTCGAAGGCGTGCCCAATTATCCCGACGTGTCGCGTTTCTGGCAGGTGGTGGAAAAGCA
CAAGGTCAACATCTTCTACACCGCCCCCACCGCCATCCGCGCCCTGATGCGCGAGGGCGAGGAGCCGGTGAAGAAGCATG
ACCGCTCGTCGCTGCGCATCCTTGGCTCGGTCGGCGAACCGATCAATCCCGAGGCCTGGACCTGGTACCACCGGGTGGTG
GGCGAGGATCGGTGCCCGATCGTCGATACTTGGTGGCAGACCGAAACCGGCGGCATCCTGATCACGCCGCTGCCCGGGGC
GACCAAGCTCAAGCCCGGATCGGCCACCTTGCCGTTCTTCGGGGTCGAGCCGGTGCTGGTCGATGCCGAGGGCAACGAAC
TGAGCGGGGCGACCGAGGGCAATCTGTGCATCGCCCGCTCGTGGCCGGGGCAGATGCGCACGGTCTATGGCGATCACGAG
CGCTTCGTGCAGACCTATTTCTCCACCTACAAGGGCTATTACTTCACCGGCGACGGCTGCCGCCGCGACGAGGACGGCTA
TTACTGGATCACCGGCCGCGTCGATGACGTCATCAACGTGTCGGGCCACCGCATGGGAACGGCCGAGATCGAATCGGCCC
TGGTCGCCCATCCCAAGGTGGCCGAAGCCGCCGTCGTCGGCTTCCCCCACGACATCAAGGGCCAAGGCATCTACGCCTAT
GTCACCCTGGTGGCCGGCGAGAAGGAAACCGACGCCCTGCGCAAGGAACTGGTGGCCTGGGTCCGCAAGGACATCGGACC
GATCGCCAGCCCCGATATCATCCAGTGGGCGCCCGGCCTGCCCAAGACGCGCTCGGGCAAGATCATGCGCCGCATCCTGC
GCAAGATCGCCGAGAACGAATTCGGCGCCCTTGGCGATACCTCGACCCTGGCCGATCCGACGGTGGTGGAAGACCTGATC
GCCAATCGTCCCCAGGCGTAA

Upstream 100 bases:

>100_bases
CGAAATCCCATGACAGCGAAGGCCGGTTGCTTTTAGAGTTACGCCAACGATCAATTCCGCTGAAAGCGGAAACATTAGTG
AAAAAAAGGGGAGAGAGTAC

Downstream 100 bases:

>100_bases
AACGCGGCGGGCGAAGACCCAAGCAGGCGAGGGGCCGGGCGGCAACGTCCGGCCCTTTTCGCTGACGGCTTTCCACAGCC
CCCCCCTTGGCTTATACATC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MSESVLVPVPEAIAKAALVNEAQYLDLYKSSIADPDAFWAEHGKRIDWIKPFTAVKDVSFDPHDVHIRWFHDGTLNVSVN
CLDRHLETRGDQTAILWEGDDPKDDARITYRDLYERVCKLANAFRELGVKKGDRVCIYLPMIPEAAVAMLACARIGAVHS
IVFGGFSPDSLANRIQDSECTLVITSDEGLRGGRKVALKKNVDTALEHCPSVKTVVVVKRTGGAIDTVEGRDVWYHEITA
NQPAECQPEEMNAEDPLFILYTSGSTGKPKGVLHTSGGYLVYVSMTHEYVFDYKDGEVYWCTADVGWVTGHSYIVYGPLA
NGAISLMFEGVPNYPDVSRFWQVVEKHKVNIFYTAPTAIRALMREGEEPVKKHDRSSLRILGSVGEPINPEAWTWYHRVV
GEDRCPIVDTWWQTETGGILITPLPGATKLKPGSATLPFFGVEPVLVDAEGNELSGATEGNLCIARSWPGQMRTVYGDHE
RFVQTYFSTYKGYYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEIESALVAHPKVAEAAVVGFPHDIKGQGIYAY
VTLVAGEKETDALRKELVAWVRKDIGPIASPDIIQWAPGLPKTRSGKIMRRILRKIAENEFGALGDTSTLADPTVVEDLI
ANRPQA

Sequences:

>Translated_646_residues
MSESVLVPVPEAIAKAALVNEAQYLDLYKSSIADPDAFWAEHGKRIDWIKPFTAVKDVSFDPHDVHIRWFHDGTLNVSVN
CLDRHLETRGDQTAILWEGDDPKDDARITYRDLYERVCKLANAFRELGVKKGDRVCIYLPMIPEAAVAMLACARIGAVHS
IVFGGFSPDSLANRIQDSECTLVITSDEGLRGGRKVALKKNVDTALEHCPSVKTVVVVKRTGGAIDTVEGRDVWYHEITA
NQPAECQPEEMNAEDPLFILYTSGSTGKPKGVLHTSGGYLVYVSMTHEYVFDYKDGEVYWCTADVGWVTGHSYIVYGPLA
NGAISLMFEGVPNYPDVSRFWQVVEKHKVNIFYTAPTAIRALMREGEEPVKKHDRSSLRILGSVGEPINPEAWTWYHRVV
GEDRCPIVDTWWQTETGGILITPLPGATKLKPGSATLPFFGVEPVLVDAEGNELSGATEGNLCIARSWPGQMRTVYGDHE
RFVQTYFSTYKGYYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEIESALVAHPKVAEAAVVGFPHDIKGQGIYAY
VTLVAGEKETDALRKELVAWVRKDIGPIASPDIIQWAPGLPKTRSGKIMRRILRKIAENEFGALGDTSTLADPTVVEDLI
ANRPQA
>Mature_645_residues
SESVLVPVPEAIAKAALVNEAQYLDLYKSSIADPDAFWAEHGKRIDWIKPFTAVKDVSFDPHDVHIRWFHDGTLNVSVNC
LDRHLETRGDQTAILWEGDDPKDDARITYRDLYERVCKLANAFRELGVKKGDRVCIYLPMIPEAAVAMLACARIGAVHSI
VFGGFSPDSLANRIQDSECTLVITSDEGLRGGRKVALKKNVDTALEHCPSVKTVVVVKRTGGAIDTVEGRDVWYHEITAN
QPAECQPEEMNAEDPLFILYTSGSTGKPKGVLHTSGGYLVYVSMTHEYVFDYKDGEVYWCTADVGWVTGHSYIVYGPLAN
GAISLMFEGVPNYPDVSRFWQVVEKHKVNIFYTAPTAIRALMREGEEPVKKHDRSSLRILGSVGEPINPEAWTWYHRVVG
EDRCPIVDTWWQTETGGILITPLPGATKLKPGSATLPFFGVEPVLVDAEGNELSGATEGNLCIARSWPGQMRTVYGDHER
FVQTYFSTYKGYYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEIESALVAHPKVAEAAVVGFPHDIKGQGIYAYV
TLVAGEKETDALRKELVAWVRKDIGPIASPDIIQWAPGLPKTRSGKIMRRILRKIAENEFGALGDTSTLADPTVVEDLIA
NRPQA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=55.0224887556222, Blast_Score=737, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=53.9705882352941, Blast_Score=733, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=623, Percent_Identity=52.4879614767255, Blast_Score=685, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.007874015748, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI42544132, Length=543, Percent_Identity=30.0184162062615, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI38505220, Length=517, Percent_Identity=31.5280464216634, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI122937307, Length=551, Percent_Identity=27.9491833030853, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI115511026, Length=539, Percent_Identity=29.1280148423006, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI31982927, Length=639, Percent_Identity=25.1956181533646, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI58082049, Length=563, Percent_Identity=26.8206039076377, Blast_Score=176, Evalue=9e-44,
Organism=Homo sapiens, GI157311624, Length=563, Percent_Identity=26.2877442273535, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI157311622, Length=563, Percent_Identity=26.2877442273535, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI187761345, Length=566, Percent_Identity=27.208480565371, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI187761343, Length=566, Percent_Identity=27.208480565371, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI195947378, Length=441, Percent_Identity=26.7573696145125, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI42544134, Length=348, Percent_Identity=26.1494252873563, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI156151445, Length=551, Percent_Identity=23.956442831216, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=66.9767441860465, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=636, Percent_Identity=38.9937106918239, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=24.3772241992883, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=23.8636363636364, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=510, Percent_Identity=24.9019607843137, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=23.1357552581262, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982997, Length=660, Percent_Identity=50.1515151515151, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=656, Percent_Identity=50.3048780487805, Blast_Score=644, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=650, Percent_Identity=21.6923076923077, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17538037, Length=527, Percent_Identity=24.6679316888046, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=540, Percent_Identity=25.1851851851852, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=524, Percent_Identity=23.6641221374046, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=519, Percent_Identity=24.2774566473988, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=561, Percent_Identity=24.4206773618538, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323182, Length=644, Percent_Identity=49.2236024844721, Blast_Score=634, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=47.7165354330709, Blast_Score=596, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319699, Length=540, Percent_Identity=25.5555555555556, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24667955, Length=663, Percent_Identity=54.2986425339367, Blast_Score=717, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=563, Percent_Identity=59.3250444049734, Blast_Score=672, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=521, Percent_Identity=59.8848368522073, Blast_Score=627, Evalue=1e-180,
Organism=Drosophila melanogaster, GI21355225, Length=616, Percent_Identity=37.6623376623377, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=24.1316270566728, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859661, Length=515, Percent_Identity=25.2427184466019, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24581924, Length=523, Percent_Identity=22.3709369024857, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24656500, Length=527, Percent_Identity=22.5806451612903, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356947, Length=368, Percent_Identity=24.4565217391304, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71569; Mature: 71438

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVLVPVPEAIAKAALVNEAQYLDLYKSSIADPDAFWAEHGKRIDWIKPFTAVKDVSF
CCCCEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCEECEECCCHHHHCCCC
DPHDVHIRWFHDGTLNVSVNCLDRHLETRGDQTAILWEGDDPKDDARITYRDLYERVCKL
CCCEEEEEEEECCEEEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHH
ANAFRELGVKKGDRVCIYLPMIPEAAVAMLACARIGAVHSIVFGGFSPDSLANRIQDSEC
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCE
TLVITSDEGLRGGRKVALKKNVDTALEHCPSVKTVVVVKRTGGAIDTVEGRDVWYHEITA
EEEEECCCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEECCCCEECCCCCEEEEEEECC
NQPAECQPEEMNAEDPLFILYTSGSTGKPKGVLHTSGGYLVYVSMTHEYVFDYKDGEVYW
CCCCCCCCHHCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEEEE
CTADVGWVTGHSYIVYGPLANGAISLMFEGVPNYPDVSRFWQVVEKHKVNIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHHHH
ALMREGEEPVKKHDRSSLRILGSVGEPINPEAWTWYHRVVGEDRCPIVDTWWQTETGGIL
HHHHCCCCHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEE
ITPLPGATKLKPGSATLPFFGVEPVLVDAEGNELSGATEGNLCIARSWPGQMRTVYGDHE
EECCCCCCEECCCCCCCCEECCCEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEECCHH
RFVQTYFSTYKGYYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEIESALVAHPKV
HHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCH
AEAAVVGFPHDIKGQGIYAYVTLVAGEKETDALRKELVAWVRKDIGPIASPDIIQWAPGL
HCEEEECCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
PKTRSGKIMRRILRKIAENEFGALGDTSTLADPTVVEDLIANRPQA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SESVLVPVPEAIAKAALVNEAQYLDLYKSSIADPDAFWAEHGKRIDWIKPFTAVKDVSF
CCCEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCEECEECCCHHHHCCCC
DPHDVHIRWFHDGTLNVSVNCLDRHLETRGDQTAILWEGDDPKDDARITYRDLYERVCKL
CCCEEEEEEEECCEEEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHH
ANAFRELGVKKGDRVCIYLPMIPEAAVAMLACARIGAVHSIVFGGFSPDSLANRIQDSEC
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCE
TLVITSDEGLRGGRKVALKKNVDTALEHCPSVKTVVVVKRTGGAIDTVEGRDVWYHEITA
EEEEECCCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEECCCCEECCCCCEEEEEEECC
NQPAECQPEEMNAEDPLFILYTSGSTGKPKGVLHTSGGYLVYVSMTHEYVFDYKDGEVYW
CCCCCCCCHHCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEEEE
CTADVGWVTGHSYIVYGPLANGAISLMFEGVPNYPDVSRFWQVVEKHKVNIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHHHH
ALMREGEEPVKKHDRSSLRILGSVGEPINPEAWTWYHRVVGEDRCPIVDTWWQTETGGIL
HHHHCCCCHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEE
ITPLPGATKLKPGSATLPFFGVEPVLVDAEGNELSGATEGNLCIARSWPGQMRTVYGDHE
EECCCCCCEECCCCCCCCEECCCEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEECCHH
RFVQTYFSTYKGYYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEIESALVAHPKV
HHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCH
AEAAVVGFPHDIKGQGIYAYVTLVAGEKETDALRKELVAWVRKDIGPIASPDIIQWAPGL
HCEEEECCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
PKTRSGKIMRRILRKIAENEFGALGDTSTLADPTVVEDLIANRPQA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA