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The map label for this gene is hemC [H]

Identifier: 83594897

GI number: 83594897

Start: 4113345

End: 4114310

Strand: Reverse

Name: hemC [H]

Synonym: Rru_A3568

Alternate gene names: 83594897

Gene position: 4114310-4113345 (Counterclockwise)

Preceding gene: 83594906

Following gene: 83594896

Centisome position: 94.52

GC content: 65.32

Gene sequence:

>966_bases
ATGATGACCGCTATAGAGAAATCCAAACTCAGAATCGGCACGCGGGGGAGTCCCCTGGCGCTTGCCCAGACCCATCAGGT
CCGTGATCTGCTGATCGCGGCCAATCCCGACCTCGGCGAGCCCGGGGCCGTGACCATCGAAGTCATCAAGACAACCGGCG
ACGCCATCCTTGATCGGCCGCTGTCCGAGCTTGGCGGCAAGGGCCTGTTCACCCGCGAAATCGATGATGCCATGCTTGCC
GGCACCATCGATATCGCCGTCCATTCCATGAAGGACGTGCCGACCTATCTGCCCGATGGCATCGTTCTGCCCTGTATGCT
GGAACGCGAGGATGTGCGCGACGCCTTCCTCGGCCGCGATCACGCCCGGCTGGCCGATCTGCCCGAAGGGTCGGTGGTCG
GTACCGCCTCCCTGCGGCGCGGTGCCCAGATCCTGGCCATGCGTCCCGACATCAAGGTGATATCCTTCCGCGGCAATGTC
CAGACCCGGCTGGACAAACTCGCCCGCGGCGAGGCCGATGCCACCATGCTGGCCATCGCCGGCCTCAACCGCCTGGGCAT
GGCCGATAAGGCCAGCTCGGTGCTCGAGATCGACGAGATGCTGCCCGCCGTCGCCCAGGGCGCCGTCGGCGTCACCTGTC
GCGCCGGCGACGAGACCGCCCATCGCTGGCTGGCCCCGCTCAATCACCGGGCCACCCAACTTTGCGTTGAGATCGAACGG
GCCTTCCTGACCCGGCTCGATGGCAGTTGCCGGACGCCGATCGGTGGGCTGGCTCGCCTAAAACGCGTGGAGGACCCTAG
CGGAACGGTGTTCTTCCGTGGCATGATCATCCGTACCGATGGTAAGGTGATTCACCAAACCACGCGGGAAGGTCTTGCCG
CCGACGGAATCGCCCTTGGGGACGATGCCGGGGCGGAGCTTCTTGCGAAAGCCGGCCCGGGGTTCTTCCAGGTCGGCGCT
TTGTGA

Upstream 100 bases:

>100_bases
GTCACAACTTGTCTCGATTCCGAGAACGCGAAAGGGCATGCTCATTGCCTCTTACACTTGCCTCTTTCAAACGGCGATCC
AAGCCCTTACAACAAGCAGC

Downstream 100 bases:

>100_bases
CAGTGTCAACGGCTCAAGGCGGACCGGCCCGGGCATGCGCGCACTTATTACACGTCCTTTGGAAGACGCCGATCGCATCG
GCGCGCTCTTGCGCGCGCGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MMTAIEKSKLRIGTRGSPLALAQTHQVRDLLIAANPDLGEPGAVTIEVIKTTGDAILDRPLSELGGKGLFTREIDDAMLA
GTIDIAVHSMKDVPTYLPDGIVLPCMLEREDVRDAFLGRDHARLADLPEGSVVGTASLRRGAQILAMRPDIKVISFRGNV
QTRLDKLARGEADATMLAIAGLNRLGMADKASSVLEIDEMLPAVAQGAVGVTCRAGDETAHRWLAPLNHRATQLCVEIER
AFLTRLDGSCRTPIGGLARLKRVEDPSGTVFFRGMIIRTDGKVIHQTTREGLAADGIALGDDAGAELLAKAGPGFFQVGA
L

Sequences:

>Translated_321_residues
MMTAIEKSKLRIGTRGSPLALAQTHQVRDLLIAANPDLGEPGAVTIEVIKTTGDAILDRPLSELGGKGLFTREIDDAMLA
GTIDIAVHSMKDVPTYLPDGIVLPCMLEREDVRDAFLGRDHARLADLPEGSVVGTASLRRGAQILAMRPDIKVISFRGNV
QTRLDKLARGEADATMLAIAGLNRLGMADKASSVLEIDEMLPAVAQGAVGVTCRAGDETAHRWLAPLNHRATQLCVEIER
AFLTRLDGSCRTPIGGLARLKRVEDPSGTVFFRGMIIRTDGKVIHQTTREGLAADGIALGDDAGAELLAKAGPGFFQVGA
L
>Mature_321_residues
MMTAIEKSKLRIGTRGSPLALAQTHQVRDLLIAANPDLGEPGAVTIEVIKTTGDAILDRPLSELGGKGLFTREIDDAMLA
GTIDIAVHSMKDVPTYLPDGIVLPCMLEREDVRDAFLGRDHARLADLPEGSVVGTASLRRGAQILAMRPDIKVISFRGNV
QTRLDKLARGEADATMLAIAGLNRLGMADKASSVLEIDEMLPAVAQGAVGVTCRAGDETAHRWLAPLNHRATQLCVEIER
AFLTRLDGSCRTPIGGLARLKRVEDPSGTVFFRGMIIRTDGKVIHQTTREGLAADGIALGDDAGAELLAKAGPGFFQVGA
L

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=279, Percent_Identity=39.7849462365591, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI66933009, Length=279, Percent_Identity=39.7849462365591, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI48994974, Length=299, Percent_Identity=47.4916387959866, Blast_Score=248, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6319996, Length=281, Percent_Identity=33.8078291814947, Blast_Score=158, Evalue=9e-40,
Organism=Drosophila melanogaster, GI20130425, Length=265, Percent_Identity=42.6415094339623, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34156; Mature: 34156

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTAIEKSKLRIGTRGSPLALAQTHQVRDLLIAANPDLGEPGAVTIEVIKTTGDAILDRP
CCCCCCCCCEEECCCCCCEEEHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCHHHHHCC
LSELGGKGLFTREIDDAMLAGTIDIAVHSMKDVPTYLPDGIVLPCMLEREDVRDAFLGRD
HHHHCCCCEEEHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHCCC
HARLADLPEGSVVGTASLRRGAQILAMRPDIKVISFRGNVQTRLDKLARGEADATMLAIA
CHHHCCCCCCCEEEHHHHHCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEC
GLNRLGMADKASSVLEIDEMLPAVAQGAVGVTCRAGDETAHRWLAPLNHRATQLCVEIER
CCHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHH
AFLTRLDGSCRTPIGGLARLKRVEDPSGTVFFRGMIIRTDGKVIHQTTREGLAADGIALG
HHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCCCEEEC
DDAGAELLAKAGPGFFQVGAL
CCCCHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MMTAIEKSKLRIGTRGSPLALAQTHQVRDLLIAANPDLGEPGAVTIEVIKTTGDAILDRP
CCCCCCCCCEEECCCCCCEEEHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCHHHHHCC
LSELGGKGLFTREIDDAMLAGTIDIAVHSMKDVPTYLPDGIVLPCMLEREDVRDAFLGRD
HHHHCCCCEEEHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHCCC
HARLADLPEGSVVGTASLRRGAQILAMRPDIKVISFRGNVQTRLDKLARGEADATMLAIA
CHHHCCCCCCCEEEHHHHHCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEC
GLNRLGMADKASSVLEIDEMLPAVAQGAVGVTCRAGDETAHRWLAPLNHRATQLCVEIER
CCHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHH
AFLTRLDGSCRTPIGGLARLKRVEDPSGTVFFRGMIIRTDGKVIHQTTREGLAADGIALG
HHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCCCEEEC
DDAGAELLAKAGPGFFQVGAL
CCCCHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA