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The map label for this gene is ahcY [H]

Identifier: 83594773

GI number: 83594773

Start: 3967502

End: 3968905

Strand: Reverse

Name: ahcY [H]

Synonym: Rru_A3444

Alternate gene names: 83594773

Gene position: 3968905-3967502 (Counterclockwise)

Preceding gene: 83594774

Following gene: 83594772

Centisome position: 91.18

GC content: 64.03

Gene sequence:

>1404_bases
ATGAGCTTCACCGATTATGTGGTCACGGACATTTCCCTGGCGGACTGGGGTCGCAAGGAGATCGACATCGCCGAAAGCGA
AATGCCCGGGCTGATGGCGACGCGGGCCGAATACGCCAAGGCCCAGCCGCTCAAGGGCGCGCGGGTCGCCGGCTCGCTGC
ATATGACCATCCAGACGGCGGTGCTGATCGAGACCCTGGTGGCGCTGGGCGCCGATGTCCGCTGGGCCTCGTGTAACATC
TATTCGACCCAGGACCACGCCGCCGCCGCCATCGCCGCCGCCGGCATCCCGGTTTTCGCCCGCAAGGGGGAAGGCCTGGA
GGATTATTGGGACTACACCCATAAGATCTTCGAATGGGCCGATGGCGGCACGCCGAACATGATCCTTGATGACGGCGGCG
ACGCCACCTTGCTCATCCACCTCGGCGCCCGCGCCGAAAAGGACGCTTCGCTGCTCGACAATCCGACCAGCGAAGAAGAG
GAAGTGCTTTACGCCGCGATCAAGGCCCGTTTGGCGGCCAAGCCCGGCTGGTATTCCACCGTTCTCGCCGCGATCAAGGG
CGTGACCGAGGAGACCACCACCGGCGTTCACCGGCTTTACGAGATGGAGAAGGCCGGGACCCTGCCGTTCCCGGCGATCA
ACGTCAACGACTCGGTGACCAAGTCGAAGTTCGACAACAAATACGGCTGCCGCGAATCCCTGGTCGACGGCATCCGCCGC
GCCACCGACGTGATGATGGCGGGCAAGGTCGCCGTGGTCGCCGGCTATGGCGATGTCGGCAAGGGCTCGTCGGAATCGCT
GCGCAGCTCCGGCTGCCGGGTGCTGGTGACCGAGGTCGATCCGATCTGCGCCCTGCAGGCGGCCATGGAGGGCTTCGAGG
TGGTGACCATGGAGGACGCCGCGCCGCGCGGCGATATCTTCGTGACCACCACCGGCAATATCGACGTCATCACCCTTGAT
CACATGCGGGCGATGAAGGATCGGGCGATCGTTTGCAACATCGGCCATTTCGATAACGAGATCCAGGTCGCCGCCCTCAA
GAACCTCACCTGGAACAACGTCAAGCCGCAGGTCGACGAGATCACCTTCCCCGATGGTCACCGCATCATCCTGCTCGCCC
AGGGCCGGCTGGTGAACCTGGGGTGCGCCACCGGCCACCCCAGCTTCGTCATGAGCGCCTCGTTCACCAATCAGACCCTG
GCCCAGATCGAGCTGTTCGCCAATAACGCCGATGGCAAATACGCCAACCGCGTTTACGTGCTGCCCAAGCATCTCGATGA
GAAGGTGGCCCGCCTGCATCTGGAAAAGCTTGGCGTGCGCTTGTCCACCCTGTCGCCCAAGCAGGCCGCCTATATCGGCG
TGACGCCCCAGGGCCCGTTCAAGGGCGAGGCCTACCGCTACTAG

Upstream 100 bases:

>100_bases
TCGCCCTCGGCTAAAATCTACTTGATAAGGATATAAAGATATCTTTATATTCCCGCCGCCGCCCTCGCATGCGGCCCCTT
CCCTATTGCGGAGAGCAGCA

Downstream 100 bases:

>100_bases
GACCTCATACGGCTCCGGGCCTTTTTTCGCCCGACTCCGCTTGGCTGACGGCCCCTTCCGCAAGGAAGGGGCCGTTGGCG
CTTTCGCCGGCGGGGGAGAT

Product: s-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTAVLIETLVALGADVRWASCNI
YSTQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWADGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEE
EVLYAAIKARLAAKPGWYSTVLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRR
ATDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDAAPRGDIFVTTTGNIDVITLD
HMRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDEITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTL
AQIELFANNADGKYANRVYVLPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY

Sequences:

>Translated_467_residues
MSFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTAVLIETLVALGADVRWASCNI
YSTQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWADGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEE
EVLYAAIKARLAAKPGWYSTVLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRR
ATDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDAAPRGDIFVTTTGNIDVITLD
HMRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDEITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTL
AQIELFANNADGKYANRVYVLPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY
>Mature_466_residues
SFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTAVLIETLVALGADVRWASCNIY
STQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWADGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEEE
VLYAAIKARLAAKPGWYSTVLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRRA
TDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDAAPRGDIFVTTTGNIDVITLDH
MRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDEITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTLA
QIELFANNADGKYANRVYVLPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=464, Percent_Identity=59.4827586206897, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=59.0497737556561, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=48.7124463519313, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=48.7124463519313, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=48.7124463519313, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=48.7124463519313, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=47.2103004291845, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.5698924731183, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=59.2050209205021, Blast_Score=521, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=469, Percent_Identity=61.1940298507463, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24656245, Length=467, Percent_Identity=49.4646680942184, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=50.4291845493562, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=50.3225806451613, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50617; Mature: 50486

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTA
CCCCCEEEEEEEHHCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEEEEHHHHH
VLIETLVALGADVRWASCNIYSTQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWA
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
DGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEEEVLYAAIKARLAAKPGWYST
CCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
VLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRR
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHH
ATDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDA
HHHHHEECCEEEEECCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEECCC
APRGDIFVTTTGNIDVITLDHMRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDE
CCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCE
ITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTLAQIELFANNADGKYANRVYV
EECCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCEEEE
LPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY
ECHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTA
CCCCEEEEEEEHHCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEEEEHHHHH
VLIETLVALGADVRWASCNIYSTQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWA
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
DGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEEEVLYAAIKARLAAKPGWYST
CCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
VLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRR
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHH
ATDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDA
HHHHHEECCEEEEECCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEECCC
APRGDIFVTTTGNIDVITLDHMRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDE
CCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCE
ITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTLAQIELFANNADGKYANRVYV
EECCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCEEEE
LPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY
ECHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]