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The map label for this gene is trpF

Identifier: 83594754

GI number: 83594754

Start: 3942558

End: 3943214

Strand: Direct

Name: trpF

Synonym: Rru_A3425

Alternate gene names: 83594754

Gene position: 3942558-3943214 (Clockwise)

Preceding gene: 83594753

Following gene: 83594755

Centisome position: 90.57

GC content: 68.95

Gene sequence:

>657_bases
ATGAGCGAGACCCTGATCAAGATCTGTGGATTGACCGACGAGGACGGCGTCGATGCCGCCGTCGAAGCCGGGGTCGACAT
GATCGGCTTCGTTTTCTTCGAGCCCTCGCCGCGCGATCTCGATCCGGCGCGGGCGGCCGAACTGCTGGACGGCGTGCCCC
ATGCCGAAGAGGGCGGGCCGCTGCGCGTCGGTTTGTTCGTCGATGCCGATGATGCGACCCTGGAGGCGGTTTTCGCCGGG
GTGCGCCTGGACGTTTTGCAGTTCCATGGCGAGGAAAGCCCCGAGCGGGTGGAATGGGCGCGCCTGGAATACGGCCTGCC
GGTGATCAAGGCCCTGCCGATCGCCAGCGCCGCCGATCTGGAGCGGGCGGCGCTTTATGCCGAGGTCGCCGATTACCTGC
TGTTTGACGCCCGCCCCCCGGCCGGCGCCGACCGCCCGGGCGGCCATGCCCAGACCTTCGACTGGTCGCTGCTGGCCGGT
TTCTCGGCGCCGGTGCCCTGGTTGCTGGCCGGCGGCCTGACGCCCGAGAACGTCGCCGAAGCCATCAAGGTCAGCGGCGC
CACCGCCGTGGATGTGTCGAGCGGCGTGGAGACGGTGCGCGGGATCAAGGATCCCGAGCGCGTCAGCGCCTTCGTCAAAG
CCGTTCGCGAAGGCTGA

Upstream 100 bases:

>100_bases
CCGATGTGCTGGTGATCGGCCGGCCGATCACCGGGGCGACCGATCCCGCCCAGGCGGCGCGGCTGATCGCCGGGGAAATC
GTGGGATGGGACGTCGGGAT

Downstream 100 bases:

>100_bases
AGCGCCATGATCCCGCCCTATCGCGAGCACCCGCTGCGCGAGGTGTTGATTAACGAGTTGCACGCCCGGCCCTCGGAAAC
CATCGAGGCGCCGGTCCGGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSETLIKICGLTDEDGVDAAVEAGVDMIGFVFFEPSPRDLDPARAAELLDGVPHAEEGGPLRVGLFVDADDATLEAVFAG
VRLDVLQFHGEESPERVEWARLEYGLPVIKALPIASAADLERAALYAEVADYLLFDARPPAGADRPGGHAQTFDWSLLAG
FSAPVPWLLAGGLTPENVAEAIKVSGATAVDVSSGVETVRGIKDPERVSAFVKAVREG

Sequences:

>Translated_218_residues
MSETLIKICGLTDEDGVDAAVEAGVDMIGFVFFEPSPRDLDPARAAELLDGVPHAEEGGPLRVGLFVDADDATLEAVFAG
VRLDVLQFHGEESPERVEWARLEYGLPVIKALPIASAADLERAALYAEVADYLLFDARPPAGADRPGGHAQTFDWSLLAG
FSAPVPWLLAGGLTPENVAEAIKVSGATAVDVSSGVETVRGIKDPERVSAFVKAVREG
>Mature_217_residues
SETLIKICGLTDEDGVDAAVEAGVDMIGFVFFEPSPRDLDPARAAELLDGVPHAEEGGPLRVGLFVDADDATLEAVFAGV
RLDVLQFHGEESPERVEWARLEYGLPVIKALPIASAADLERAALYAEVADYLLFDARPPAGADRPGGHAQTFDWSLLAGF
SAPVPWLLAGGLTPENVAEAIKVSGATAVDVSSGVETVRGIKDPERVSAFVKAVREG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=212, Percent_Identity=31.1320754716981, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=225, Percent_Identity=30.2222222222222, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_RHORT (Q2RNS6)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428506.1
- ProteinModelPortal:   Q2RNS6
- SMR:   Q2RNS6
- STRING:   Q2RNS6
- GeneID:   3836877
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3425
- NMPDR:   fig|1085.1.peg.2072
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q2RNS6
- ProtClustDB:   PRK01222
- BioCyc:   RRUB269796:RRU_A3425-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22995; Mature: 22864

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETLIKICGLTDEDGVDAAVEAGVDMIGFVFFEPSPRDLDPARAAELLDGVPHAEEGGP
CCCCEEEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCC
LRVGLFVDADDATLEAVFAGVRLDVLQFHGEESPERVEWARLEYGLPVIKALPIASAADL
EEEEEEEECCCHHHHHHHHHHHHEEHHHCCCCCCCHHHHHHHHCCCCHHHHCCCCCHHHH
ERAALYAEVADYLLFDARPPAGADRPGGHAQTFDWSLLAGFSAPVPWLLAGGLTPENVAE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCCCCHHHHHH
AIKVSGATAVDVSSGVETVRGIKDPERVSAFVKAVREG
HHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SETLIKICGLTDEDGVDAAVEAGVDMIGFVFFEPSPRDLDPARAAELLDGVPHAEEGGP
CCCEEEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCC
LRVGLFVDADDATLEAVFAGVRLDVLQFHGEESPERVEWARLEYGLPVIKALPIASAADL
EEEEEEEECCCHHHHHHHHHHHHEEHHHCCCCCCCHHHHHHHHCCCCHHHHCCCCCHHHH
ERAALYAEVADYLLFDARPPAGADRPGGHAQTFDWSLLAGFSAPVPWLLAGGLTPENVAE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCCCCHHHHHH
AIKVSGATAVDVSSGVETVRGIKDPERVSAFVKAVREG
HHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA