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The map label for this gene is macA [H]

Identifier: 83594565

GI number: 83594565

Start: 3730807

End: 3731982

Strand: Direct

Name: macA [H]

Synonym: Rru_A3235

Alternate gene names: 83594565

Gene position: 3730807-3731982 (Clockwise)

Preceding gene: 83594564

Following gene: 83594566

Centisome position: 85.71

GC content: 68.03

Gene sequence:

>1176_bases
ATGCCCCCACCCCCCGCTTCCCGGCCGCGCCGGCCTTCCCGCCGTACCCTTGTTCTGATCCTTGGCCTTCTCGCCGCCTG
CGCTCTCGGCGCCTGGGCACTCGGCTGGTTCGGCGCCAATGGCGACAAGGCGCCACCGCCGCGCCAGCAGACCGTCGAGT
TGGGCAGCGTCGAAAACGCCATCACCGCCGTCGGCTCGCTCCAGCCCAAAACCTATGTCGATGTCGGCGCCCAGGTCTCG
GGCAAGGTCTCCCATCTGCCCGTCGTCATCGGCGACCGGGTGGAAAAGGGCGATCTGCTGACCGTCATCGATCCCCGCAC
CTATGAAGCCCGGGTGCGCACCGACAAGGCGGCTTTGGCCAAGCTGCACGCCGACCGCCGAAAGGCCGAGGCCCAGCTTG
GGCTGTCGCGCCAGCAACGCGCCCGCACCGAACGGCTGTTCCAGGCCAAGGCGACCAGCCAGGATTCCCTGGATTCGGCC
CGGACCACCGTTCTTGTCGATCAGGCGGCGATCGAATCGATCGATGCCCAGATCGAACAGGCCCTGGCCGAGCTTGACGC
CGATCAGGCCGATCTTGATTACACCCAGGTCTATGCGACGATGAGCGGCACCATTGTGTCGATCGCCGTGGTCGAGGGGC
AAACCCTGAACTCGGTGCAATCGGCCCCCGATCTGATGCGCATCGCCGATCTCGACACCATGACCGTCAAGGCCGAGGTC
GCCGAGGCCGATATCACCGCGATCAAACCCGGCATGCCGGGCTATTTCACCACCCTGGGCGGCGGCGGACGGCGCTGGCA
GGGCACCGTGCGGCTGATCGAGCCGACCCCGGTCACCGACAACGACGTGGTGCTTTATAACGTGCTGATGGATGTGGCCA
ATCCCGATGGCGCGCTGATGACCGACATGACCGCCCAGGTCTTTTTCCTCAAGGACCGGGCCGAGAACGTGCCGGTGGTG
CCGCTGGCAGCCTTGACGCCGACGGCGACGGCCGGCACCTGGACGGCCAGCGTGCAGGGCCCGGGCGGCCTGGAACAGCG
CACCGTGACCACCGGCGTCGTCAATCGCGCCCTGGCCCAGGTGGTCGACGGGCTGGCGGTTGGCGACAAGGTGGTGCTGC
CGCGCGCCACCCCGGGCGCCACCGCCGGCGGCTTCAAGCCGCCGCCGATGCTTTAG

Upstream 100 bases:

>100_bases
CGATTTGTAATTCCCCGCCCATGGAGTGGCGAGACGGACTGGGGCATTCTATCTGGGTAGGACGGATCCCGACCGCGGAC
CCCCCACCAACGGATAGCCC

Downstream 100 bases:

>100_bases
ATCCCACCTTTCAGACCCCGCCTTTCAGAAAGGTCGCCCCATGGCCGACACCCCCCCGCCGCTGATCGAGTTGATCGATC
TGGAACGGGTTTTCGATTCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MPPPPASRPRRPSRRTLVLILGLLAACALGAWALGWFGANGDKAPPPRQQTVELGSVENAITAVGSLQPKTYVDVGAQVS
GKVSHLPVVIGDRVEKGDLLTVIDPRTYEARVRTDKAALAKLHADRRKAEAQLGLSRQQRARTERLFQAKATSQDSLDSA
RTTVLVDQAAIESIDAQIEQALAELDADQADLDYTQVYATMSGTIVSIAVVEGQTLNSVQSAPDLMRIADLDTMTVKAEV
AEADITAIKPGMPGYFTTLGGGGRRWQGTVRLIEPTPVTDNDVVLYNVLMDVANPDGALMTDMTAQVFFLKDRAENVPVV
PLAALTPTATAGTWTASVQGPGGLEQRTVTTGVVNRALAQVVDGLAVGDKVVLPRATPGATAGGFKPPPML

Sequences:

>Translated_391_residues
MPPPPASRPRRPSRRTLVLILGLLAACALGAWALGWFGANGDKAPPPRQQTVELGSVENAITAVGSLQPKTYVDVGAQVS
GKVSHLPVVIGDRVEKGDLLTVIDPRTYEARVRTDKAALAKLHADRRKAEAQLGLSRQQRARTERLFQAKATSQDSLDSA
RTTVLVDQAAIESIDAQIEQALAELDADQADLDYTQVYATMSGTIVSIAVVEGQTLNSVQSAPDLMRIADLDTMTVKAEV
AEADITAIKPGMPGYFTTLGGGGRRWQGTVRLIEPTPVTDNDVVLYNVLMDVANPDGALMTDMTAQVFFLKDRAENVPVV
PLAALTPTATAGTWTASVQGPGGLEQRTVTTGVVNRALAQVVDGLAVGDKVVLPRATPGATAGGFKPPPML
>Mature_390_residues
PPPPASRPRRPSRRTLVLILGLLAACALGAWALGWFGANGDKAPPPRQQTVELGSVENAITAVGSLQPKTYVDVGAQVSG
KVSHLPVVIGDRVEKGDLLTVIDPRTYEARVRTDKAALAKLHADRRKAEAQLGLSRQQRARTERLFQAKATSQDSLDSAR
TTVLVDQAAIESIDAQIEQALAELDADQADLDYTQVYATMSGTIVSIAVVEGQTLNSVQSAPDLMRIADLDTMTVKAEVA
EADITAIKPGMPGYFTTLGGGGRRWQGTVRLIEPTPVTDNDVVLYNVLMDVANPDGALMTDMTAQVFFLKDRAENVPVVP
LAALTPTATAGTWTASVQGPGGLEQRTVTTGVVNRALAQVVDGLAVGDKVVLPRATPGATAGGFKPPPML

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=375, Percent_Identity=38.9333333333333, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789929, Length=333, Percent_Identity=26.4264264264264, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41314; Mature: 41182

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPPASRPRRPSRRTLVLILGLLAACALGAWALGWFGANGDKAPPPRQQTVELGSVENA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHEECCCHHHH
ITAVGSLQPKTYVDVGAQVSGKVSHLPVVIGDRVEKGDLLTVIDPRTYEARVRTDKAALA
HHHHHCCCCCEEEECCCCCCCCCEECCEEECCCCCCCCEEEEECCCCEEEHEHHHHHHHH
KLHADRRKAEAQLGLSRQQRARTERLFQAKATSQDSLDSARTTVLVDQAAIESIDAQIEQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEHHHHHHHHHHHHHH
ALAELDADQADLDYTQVYATMSGTIVSIAVVEGQTLNSVQSAPDLMRIADLDTMTVKAEV
HHHHCCCCCCCCCHHHHEEECCCCEEEEEEECCCCHHHHHCCCHHHHHHCCCCEEEEEEH
AEADITAIKPGMPGYFTTLGGGGRRWQGTVRLIEPTPVTDNDVVLYNVLMDVANPDGALM
HHCCCEEECCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCCEEEEEEHHHHCCCCCCEE
TDMTAQVFFLKDRAENVPVVPLAALTPTATAGTWTASVQGPGGLEQRTVTTGVVNRALAQ
ECCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VVDGLAVGDKVVLPRATPGATAGGFKPPPML
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPPPASRPRRPSRRTLVLILGLLAACALGAWALGWFGANGDKAPPPRQQTVELGSVENA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHEECCCHHHH
ITAVGSLQPKTYVDVGAQVSGKVSHLPVVIGDRVEKGDLLTVIDPRTYEARVRTDKAALA
HHHHHCCCCCEEEECCCCCCCCCEECCEEECCCCCCCCEEEEECCCCEEEHEHHHHHHHH
KLHADRRKAEAQLGLSRQQRARTERLFQAKATSQDSLDSARTTVLVDQAAIESIDAQIEQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEHHHHHHHHHHHHHH
ALAELDADQADLDYTQVYATMSGTIVSIAVVEGQTLNSVQSAPDLMRIADLDTMTVKAEV
HHHHCCCCCCCCCHHHHEEECCCCEEEEEEECCCCHHHHHCCCHHHHHHCCCCEEEEEEH
AEADITAIKPGMPGYFTTLGGGGRRWQGTVRLIEPTPVTDNDVVLYNVLMDVANPDGALM
HHCCCEEECCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCCEEEEEEHHHHCCCCCCEE
TDMTAQVFFLKDRAENVPVVPLAALTPTATAGTWTASVQGPGGLEQRTVTTGVVNRALAQ
ECCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VVDGLAVGDKVVLPRATPGATAGGFKPPPML
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]