Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 83594381

GI number: 83594381

Start: 3514107

End: 3515234

Strand: Reverse

Name: gcvT [H]

Synonym: Rru_A3051

Alternate gene names: 83594381

Gene position: 3515234-3514107 (Counterclockwise)

Preceding gene: 83594382

Following gene: 83594380

Centisome position: 80.76

GC content: 67.38

Gene sequence:

>1128_bases
ATGGAGCCGCATTTGTCGGACCCCACCGTTTCCCTGCTGACCACGCCGCTCCACGCCCTCCATCTGGAGCGAGGCGCCCG
CATGGTGCCCTTCGCCGGCTATGACATGCCCGTTCAATACCCGATGGGCGTTCTGGCCGAGCATCTGCACACCCGCGCAA
GCGCCGGGCTGTTCGATGTCTCGCACATGGGCCAAGCCCGTTTGGTCGGGCCGCAGCGCATCGCCGCCCTGGAAGCCCTG
GTTCCGGGCGATCTCGAAATCCTCAAGGAAGGCCGTCAGCGCTATACGGTGCTGACCAATGACCAGGGCGGCATTCTTGA
CGACCTGATGGTCACCAAGCGCGCCGATGACCTGTTCCTGGTGGTCAACGCCGCCTGCAAGGACGCCGATCTCGACCATA
TCGAGGCCCATCTGGCCGGCTTCGACGCCCGGCTCGAACGCCTGCCCGACACTGCGCTGCTCGCCCTGCAAGGGCCGCTG
GCGGTTTCGGTGCTGGCCGGTTTGGATGCCAGGGCCGCCGAGATGGGCTTCATGTCGGGGCGCTGGCTGAGCCTGTGCGG
GGTCGATTGCTTCGTTACCCGCTCGGGCTATACCGGCGAGGACGGTTTTGAAATCAGCGTGCCCGCCGAAGCCGCCCTTG
ATCTGGCGCAAACCTTGATCGCCAATGAGGCGGTGGCCTTGATCGGCCTGGGGGCGCGCGACAGCCTGCGCCTGGAGGCC
GGGTTGTGCCTCTATGGCAGCGATATCGACACCACCACCACCCCGGTCGAAGCCGGTCTGTCGTGGATCATCGGCAAGCG
TCGGCGGGCCGAGGGCGGCTTTCCCGGGGCTTCGGCGATCCAACAAGATCTGGCCCAGGGGCCCAAGCGCTGCCGCGTTG
GTCTGCGTCCCGAGGGCAAAGCGCCGGTGCGCGCCCATTCCGCCATCCTGGGGCCCCAGGGGGAGGTGGTTGGCGAAGTG
ACCTCGGGCGGCTTCTCGCCCAGCCTGTCGGCGCCGATCGCCATGGGCATGGTTCCAGCCGAACTGGCCGCGCCCGGCAC
GGCGGTTTCGCTGGTGGTGCGCGGCAAGGCCTTGCCCGCCCATGTGGTCGAGATGCCCTTCGTCGCCCATCGCTATCACA
AGGCATAG

Upstream 100 bases:

>100_bases
CCGGCGGTCCGACCCCGGTGACTCTTTCAGGTTTCGAGACAGAGGGGGGCGTTCGATAGTCGGGGACCGCCAGGGCTCCG
AACGTACGCCACCCCAGGTC

Downstream 100 bases:

>100_bases
CGTCCGGCGCGACGCGTCCCACTTATTCCTTTTGTCATCGCTTTTGTCGTCAACCGTTACCAGGCGAGGGTTCTGGTCAT
GAGCAAACTCTATTTCACCG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MEPHLSDPTVSLLTTPLHALHLERGARMVPFAGYDMPVQYPMGVLAEHLHTRASAGLFDVSHMGQARLVGPQRIAALEAL
VPGDLEILKEGRQRYTVLTNDQGGILDDLMVTKRADDLFLVVNAACKDADLDHIEAHLAGFDARLERLPDTALLALQGPL
AVSVLAGLDARAAEMGFMSGRWLSLCGVDCFVTRSGYTGEDGFEISVPAEAALDLAQTLIANEAVALIGLGARDSLRLEA
GLCLYGSDIDTTTTPVEAGLSWIIGKRRRAEGGFPGASAIQQDLAQGPKRCRVGLRPEGKAPVRAHSAILGPQGEVVGEV
TSGGFSPSLSAPIAMGMVPAELAAPGTAVSLVVRGKALPAHVVEMPFVAHRYHKA

Sequences:

>Translated_375_residues
MEPHLSDPTVSLLTTPLHALHLERGARMVPFAGYDMPVQYPMGVLAEHLHTRASAGLFDVSHMGQARLVGPQRIAALEAL
VPGDLEILKEGRQRYTVLTNDQGGILDDLMVTKRADDLFLVVNAACKDADLDHIEAHLAGFDARLERLPDTALLALQGPL
AVSVLAGLDARAAEMGFMSGRWLSLCGVDCFVTRSGYTGEDGFEISVPAEAALDLAQTLIANEAVALIGLGARDSLRLEA
GLCLYGSDIDTTTTPVEAGLSWIIGKRRRAEGGFPGASAIQQDLAQGPKRCRVGLRPEGKAPVRAHSAILGPQGEVVGEV
TSGGFSPSLSAPIAMGMVPAELAAPGTAVSLVVRGKALPAHVVEMPFVAHRYHKA
>Mature_375_residues
MEPHLSDPTVSLLTTPLHALHLERGARMVPFAGYDMPVQYPMGVLAEHLHTRASAGLFDVSHMGQARLVGPQRIAALEAL
VPGDLEILKEGRQRYTVLTNDQGGILDDLMVTKRADDLFLVVNAACKDADLDHIEAHLAGFDARLERLPDTALLALQGPL
AVSVLAGLDARAAEMGFMSGRWLSLCGVDCFVTRSGYTGEDGFEISVPAEAALDLAQTLIANEAVALIGLGARDSLRLEA
GLCLYGSDIDTTTTPVEAGLSWIIGKRRRAEGGFPGASAIQQDLAQGPKRCRVGLRPEGKAPVRAHSAILGPQGEVVGEV
TSGGFSPSLSAPIAMGMVPAELAAPGTAVSLVVRGKALPAHVVEMPFVAHRYHKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=50.2702702702703, Blast_Score=314, Evalue=9e-86,
Organism=Homo sapiens, GI257796258, Length=344, Percent_Identity=51.1627906976744, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI257796254, Length=364, Percent_Identity=46.1538461538462, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=49.8422712933754, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI24797151, Length=345, Percent_Identity=27.2463768115942, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI197927446, Length=318, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI21361378, Length=318, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=36.3636363636364, Blast_Score=185, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=44.2359249329759, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=40.5194805194805, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=45.4545454545455, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI20130091, Length=315, Percent_Identity=24.1269841269841, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39549; Mature: 39549

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPHLSDPTVSLLTTPLHALHLERGARMVPFAGYDMPVQYPMGVLAEHLHTRASAGLFDV
CCCCCCCCCHHHHHHHHHHHHHHCCCEECEECCCCCCCCCCHHHHHHHHHHHHCCCEEEH
SHMGQARLVGPQRIAALEALVPGDLEILKEGRQRYTVLTNDQGGILDDLMVTKRADDLFL
HHCCCEEECCHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCEEE
VVNAACKDADLDHIEAHLAGFDARLERLPDTALLALQGPLAVSVLAGLDARAAEMGFMSG
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHHHHHCCCCC
RWLSLCGVDCFVTRSGYTGEDGFEISVPAEAALDLAQTLIANEAVALIGLGARDSLRLEA
CCHHHCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEC
GLCLYGSDIDTTTTPVEAGLSWIIGKRRRAEGGFPGASAIQQDLAQGPKRCRVGLRPEGK
CEEEECCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
APVRAHSAILGPQGEVVGEVTSGGFSPSLSAPIAMGMVPAELAAPGTAVSLVVRGKALPA
CCCHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHCCCCHHHCCCCCEEEEEEECCCCCH
HVVEMPFVAHRYHKA
HHHHCCHHHHHHCCC
>Mature Secondary Structure
MEPHLSDPTVSLLTTPLHALHLERGARMVPFAGYDMPVQYPMGVLAEHLHTRASAGLFDV
CCCCCCCCCHHHHHHHHHHHHHHCCCEECEECCCCCCCCCCHHHHHHHHHHHHCCCEEEH
SHMGQARLVGPQRIAALEALVPGDLEILKEGRQRYTVLTNDQGGILDDLMVTKRADDLFL
HHCCCEEECCHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCEEE
VVNAACKDADLDHIEAHLAGFDARLERLPDTALLALQGPLAVSVLAGLDARAAEMGFMSG
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHHHHHCCCCC
RWLSLCGVDCFVTRSGYTGEDGFEISVPAEAALDLAQTLIANEAVALIGLGARDSLRLEA
CCHHHCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEC
GLCLYGSDIDTTTTPVEAGLSWIIGKRRRAEGGFPGASAIQQDLAQGPKRCRVGLRPEGK
CEEEECCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
APVRAHSAILGPQGEVVGEVTSGGFSPSLSAPIAMGMVPAELAAPGTAVSLVVRGKALPA
CCCHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHCCCCHHHCCCCCEEEEEEECCCCCH
HVVEMPFVAHRYHKA
HHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]