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The map label for this gene is dut [H]

Identifier: 83594123

GI number: 83594123

Start: 3225908

End: 3226372

Strand: Direct

Name: dut [H]

Synonym: Rru_A2791

Alternate gene names: 83594123

Gene position: 3225908-3226372 (Clockwise)

Preceding gene: 83594122

Following gene: 83594124

Centisome position: 74.11

GC content: 68.6

Gene sequence:

>465_bases
ATGCTTCAGATCACCTATCTTCCCCATTACGACCGCGCCACCTTTGGTCCGGTGGCCTATGCCAAGCCCGGCGACGCCGG
CTTCGACCTGCGCGCCGCCATCGCCGCGCCGATCACCATCGAGCCCGGCGACATCACCCTGGTGCCCGCCGGCATCGCCA
TGGCCGTGCCCGAGGGCTATGAGATCCAGGTGCGCTCGCGCTCCGGGCTGTCGCTGAAGGGGCTGATCGTCGCCAATGCG
CCGGGAACGGTCGATTCGGGCTATCGCGGCGAGTTCAAGGTGATCTTGACCAATATCGGTCGCGTCGCCCATACCGTCGC
CCCCGGCGACCGCATCGCCCAGGCGGTGCTGGCCGCCGTCGCCCATATGCCCTTCGTCGAAGTCGCCGAATTGCCCCCGT
CCGAGCGCGGCAGCGGCGGTTTTGGCTCGACCGGCGTGTCGGTGGCCGAAACGCCGCGCGGCTAA

Upstream 100 bases:

>100_bases
ATCCGACGATCTAGCCAAGGGTTGCCACCCACGACCGTGCCACCGATACTGCGCCCCATGTCGGCGCCCGCCGCCTTCCC
CCTGACTTAACGGACCTTTG

Downstream 100 bases:

>100_bases
TCGTCGCCGCCGCACGATGACCCGATATCAGATCACCCGACCAACGAGGACGGCATGACCGAACTGCTTTTCGCCCCCAC
CGCCACGGTGGTGGCCCACT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MLQITYLPHYDRATFGPVAYAKPGDAGFDLRAAIAAPITIEPGDITLVPAGIAMAVPEGYEIQVRSRSGLSLKGLIVANA
PGTVDSGYRGEFKVILTNIGRVAHTVAPGDRIAQAVLAAVAHMPFVEVAELPPSERGSGGFGSTGVSVAETPRG

Sequences:

>Translated_154_residues
MLQITYLPHYDRATFGPVAYAKPGDAGFDLRAAIAAPITIEPGDITLVPAGIAMAVPEGYEIQVRSRSGLSLKGLIVANA
PGTVDSGYRGEFKVILTNIGRVAHTVAPGDRIAQAVLAAVAHMPFVEVAELPPSERGSGGFGSTGVSVAETPRG
>Mature_154_residues
MLQITYLPHYDRATFGPVAYAKPGDAGFDLRAAIAAPITIEPGDITLVPAGIAMAVPEGYEIQVRSRSGLSLKGLIVANA
PGTVDSGYRGEFKVILTNIGRVAHTVAPGDRIAQAVLAAVAHMPFVEVAELPPSERGSGGFGSTGVSVAETPRG

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=120, Percent_Identity=42.5, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4503423, Length=120, Percent_Identity=42.5, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI70906441, Length=120, Percent_Identity=42.5, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790071, Length=128, Percent_Identity=38.28125, Blast_Score=93, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988561, Length=131, Percent_Identity=41.9847328244275, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319729, Length=121, Percent_Identity=40.495867768595, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921126, Length=122, Percent_Identity=40.1639344262295, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583610, Length=122, Percent_Identity=40.1639344262295, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15881; Mature: 15881

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQITYLPHYDRATFGPVAYAKPGDAGFDLRAAIAAPITIEPGDITLVPAGIAMAVPEGY
CEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEEECCEEECCCCEEEECCCEEEECCCCC
EIQVRSRSGLSLKGLIVANAPGTVDSGYRGEFKVILTNIGRVAHTVAPGDRIAQAVLAAV
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHEECCCHHHHHHHHHHHH
AHMPFVEVAELPPSERGSGGFGSTGVSVAETPRG
HHCCCEEECCCCCCCCCCCCCCCCCCEECCCCCC
>Mature Secondary Structure
MLQITYLPHYDRATFGPVAYAKPGDAGFDLRAAIAAPITIEPGDITLVPAGIAMAVPEGY
CEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEEECCEEECCCCEEEECCCEEEECCCCC
EIQVRSRSGLSLKGLIVANAPGTVDSGYRGEFKVILTNIGRVAHTVAPGDRIAQAVLAAV
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHEECCCHHHHHHHHHHHH
AHMPFVEVAELPPSERGSGGFGSTGVSVAETPRG
HHCCCEEECCCCCCCCCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA