| Definition | Rhodospirillum rubrum ATCC 11170 chromosome, complete genome. |
|---|---|
| Accession | NC_007643 |
| Length | 4,352,825 |
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The map label for this gene is fixR [H]
Identifier: 83593847
GI number: 83593847
Start: 2920328
End: 2921056
Strand: Reverse
Name: fixR [H]
Synonym: Rru_A2512
Alternate gene names: 83593847
Gene position: 2921056-2920328 (Counterclockwise)
Preceding gene: 83593848
Following gene: 83593841
Centisome position: 67.11
GC content: 64.06
Gene sequence:
>729_bases ATGAATACCGTGATCATCACCGGCGCGAGCCGGGGCATAGGCCATGCGACCGCCGTTCGTTTTCTGAACGAAGGATGGCG GGTGATTACCTGCGCCCGCGCCGATGTGCCCCCGGAATGCAAGCGCGACAAGAACTGGACGGCGCATTTCCCCGTCGATC TGTCCGATCCGGCGGCGATCGACGTCTTTGCCCGCCAGATCGTCGAGCATCTGAACGGCGATCCCCTTCACGCCCTGGTC AATAACGCCGGCGTGTCGCCCAAGACGACCTTCAAGGAGCGGCTGGGCGTGCTGAACGGCTCGATCGACCGCTGGCGCGA GGTGTTCGAGCTGAACTTTTTCGCCCCCCTGCGGCTGGCCCGGGCCTTCGCCACGCCCCTGCGCAAAAGCCGGGGCGCCA TCGTCAATATCACCTCGATCGCCGGCCATTACGTTCATCCCTTCGCCGGCTCGGCCTATTCCACCTCGAAGGCGGCGCTG TCGGGGCTGACCCGCGAGATGGCGGTGGAATTCGCCCAATTGGGGGTGCGGGTGAACGCCGTGGCGCCCGGCGAGATCAA GACCGAGATGATCGCCCCGGAATACGAAGCCTTGATCCCGCGTATTCCGCTTGATCGCATGGGCTCGACCGAGGACGTGG CGTCTTGCGTCTATCGCCTGTGCACCGAGGAATTTGGCTATGTCACCGGCACGGAGATCTATGTGACCGGCGGCCAGCAC CTGCTGTAA
Upstream 100 bases:
>100_bases GAAAAGCGGTAATTCCTTTTCCGCTCGCAGCTCTAGATGGAAAATGATAGGGGGAAAGGGTCCGCTTCGCGCATCGATCC TCCAATAGGAAACGCTCGCC
Downstream 100 bases:
>100_bases GCCTGTCGGCCGGCATCGCCTTCACAGCGGAATGACCGTCGCCGTCGTCGGTGGGCCATCGGCGGTTTCCAGGCGGTTGC GGCCGTTGGCCTTGGCTAGG
Product: 3-oxoacyl-(acyl-carrier-protein) reductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 242; Mature: 242
Protein sequence:
>242_residues MNTVIITGASRGIGHATAVRFLNEGWRVITCARADVPPECKRDKNWTAHFPVDLSDPAAIDVFARQIVEHLNGDPLHALV NNAGVSPKTTFKERLGVLNGSIDRWREVFELNFFAPLRLARAFATPLRKSRGAIVNITSIAGHYVHPFAGSAYSTSKAAL SGLTREMAVEFAQLGVRVNAVAPGEIKTEMIAPEYEALIPRIPLDRMGSTEDVASCVYRLCTEEFGYVTGTEIYVTGGQH LL
Sequences:
>Translated_242_residues MNTVIITGASRGIGHATAVRFLNEGWRVITCARADVPPECKRDKNWTAHFPVDLSDPAAIDVFARQIVEHLNGDPLHALV NNAGVSPKTTFKERLGVLNGSIDRWREVFELNFFAPLRLARAFATPLRKSRGAIVNITSIAGHYVHPFAGSAYSTSKAAL SGLTREMAVEFAQLGVRVNAVAPGEIKTEMIAPEYEALIPRIPLDRMGSTEDVASCVYRLCTEEFGYVTGTEIYVTGGQH LL >Mature_242_residues MNTVIITGASRGIGHATAVRFLNEGWRVITCARADVPPECKRDKNWTAHFPVDLSDPAAIDVFARQIVEHLNGDPLHALV NNAGVSPKTTFKERLGVLNGSIDRWREVFELNFFAPLRLARAFATPLRKSRGAIVNITSIAGHYVHPFAGSAYSTSKAAL SGLTREMAVEFAQLGVRVNAVAPGEIKTEMIAPEYEALIPRIPLDRMGSTEDVASCVYRLCTEEFGYVTGTEIYVTGGQH LL
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=33.7301587301587, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=29.9180327868852, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=30.241935483871, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=31.25, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI59889578, Length=242, Percent_Identity=29.7520661157025, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=29.9595141700405, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI20149619, Length=201, Percent_Identity=30.8457711442786, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI66933014, Length=202, Percent_Identity=29.7029702970297, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI119392083, Length=201, Percent_Identity=31.8407960199005, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI109715829, Length=203, Percent_Identity=29.5566502463054, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI19923817, Length=264, Percent_Identity=25.3787878787879, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI4504503, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI50726952, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI126723750, Length=149, Percent_Identity=30.8724832214765, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI40548397, Length=192, Percent_Identity=25, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI214010158, Length=192, Percent_Identity=25, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI214010156, Length=192, Percent_Identity=25, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI22758144, Length=192, Percent_Identity=25, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI44680136, Length=121, Percent_Identity=33.0578512396694, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI44680133, Length=121, Percent_Identity=33.0578512396694, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI17738292, Length=121, Percent_Identity=33.0578512396694, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=29.5546558704453, Blast_Score=108, Evalue=3e-25, Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=32.1285140562249, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=33.0708661417323, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=31.2977099236641, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=29.5719844357977, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=32.2314049586777, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=29.6442687747036, Blast_Score=84, Evalue=8e-18, Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=29.3877551020408, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=28.7937743190661, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=25.78125, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=28.0632411067194, Blast_Score=67, Evalue=2e-12, Organism=Escherichia coli, GI1786701, Length=191, Percent_Identity=28.7958115183246, Blast_Score=66, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=32.258064516129, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=30.3643724696356, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.5454545454545, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI71994600, Length=263, Percent_Identity=30.7984790874525, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=29.3233082706767, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=29.9242424242424, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=29.3172690763052, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=29.5019157088123, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=30.6818181818182, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=30.6818181818182, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=27.8884462151394, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=31.0344827586207, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=28.6245353159851, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI193204405, Length=259, Percent_Identity=28.957528957529, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=29.1187739463602, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI72000259, Length=271, Percent_Identity=28.7822878228782, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=29.6992481203008, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=28.3524904214559, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=30.0380228136882, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=27.4809160305344, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=29.277566539924, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI32563809, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17507613, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=28.4615384615385, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=150, Percent_Identity=32.6666666666667, Blast_Score=82, Evalue=7e-17, Organism=Saccharomyces cerevisiae, GI6323882, Length=233, Percent_Identity=30.9012875536481, Blast_Score=74, Evalue=2e-14, Organism=Saccharomyces cerevisiae, GI6322067, Length=189, Percent_Identity=30.6878306878307, Blast_Score=73, Evalue=5e-14, Organism=Saccharomyces cerevisiae, GI6322227, Length=208, Percent_Identity=29.3269230769231, Blast_Score=68, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322226, Length=193, Percent_Identity=29.5336787564767, Blast_Score=64, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6323458, Length=193, Percent_Identity=31.0880829015544, Blast_Score=62, Evalue=6e-11, Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=31.7073170731707, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=33.201581027668, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=31.5175097276265, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=28.1632653061224, Blast_Score=88, Evalue=4e-18, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=31.9672131147541, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=30.8270676691729, Blast_Score=85, Evalue=6e-17, Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=29.5719844357977, Blast_Score=82, Evalue=2e-16, Organism=Drosophila melanogaster, GI24644337, Length=200, Percent_Identity=31.5, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI24651139, Length=197, Percent_Identity=31.4720812182741, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI21358495, Length=200, Percent_Identity=29, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI116007236, Length=238, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24640547, Length=247, Percent_Identity=25.5060728744939, Blast_Score=65, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 26438; Mature: 26438
Theoretical pI: Translated: 7.58; Mature: 7.58
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTVIITGASRGIGHATAVRFLNEGWRVITCARADVPPECKRDKNWTAHFPVDLSDPAAI CCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHH DVFARQIVEHLNGDPLHALVNNAGVSPKTTFKERLGVLNGSIDRWREVFELNFFAPLRLA HHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH RAFATPLRKSRGAIVNITSIAGHYVHPFAGSAYSTSKAALSGLTREMAVEFAQLGVRVNA HHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEE VAPGEIKTEMIAPEYEALIPRIPLDRMGSTEDVASCVYRLCTEEFGYVTGTEIYVTGGQH ECCCCCHHHHCCCHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC LL CC >Mature Secondary Structure MNTVIITGASRGIGHATAVRFLNEGWRVITCARADVPPECKRDKNWTAHFPVDLSDPAAI CCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHH DVFARQIVEHLNGDPLHALVNNAGVSPKTTFKERLGVLNGSIDRWREVFELNFFAPLRLA HHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH RAFATPLRKSRGAIVNITSIAGHYVHPFAGSAYSTSKAALSGLTREMAVEFAQLGVRVNA HHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEE VAPGEIKTEMIAPEYEALIPRIPLDRMGSTEDVASCVYRLCTEEFGYVTGTEIYVTGGQH ECCCCCHHHHCCCHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC LL CC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3313281; 11157954; 12597275 [H]