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The map label for this gene is ggt [H]

Identifier: 83593759

GI number: 83593759

Start: 2823946

End: 2825175

Strand: Reverse

Name: ggt [H]

Synonym: Rru_A2424

Alternate gene names: 83593759

Gene position: 2825175-2823946 (Counterclockwise)

Preceding gene: 83593766

Following gene: 83593758

Centisome position: 64.9

GC content: 72.76

Gene sequence:

>1230_bases
ATGGTCGCCGGCTGCGCCGATGACCGCCAGATCGGCGTTGTCGGCTACATTGAAGGCTTTTCCGGGGTCGTCGCCGCCGA
TGAACCCCAGGCGGTTCTGGCCGGGCGCGATATCTTGAGCGCCGGCGGCCGCGCCGCCGATGCCGCCGTGGCCATGGCCT
TCACCCTGGCCGTCACCTTGCCCTCCGCGGCCGGGCTGGGCGGCGGCGGCCTGTGCGTGGTCTATGACGCCAAGGCCAAT
AAGGCCGAGACCCTGGATTTCCTGCCCGGCCCGGCTTCGGGGGGAATGGCCGCCTATGGCGCGCCCGGCGGCGCCTTTGG
CGGCGGGCGGGCGGTGGCGGTGCCGGCCCTGGGGCGCGGCATGTTCGCGCTGAATGCCAAATACGGCACGCTGCGCTGGG
AAGGCCTGCTCGCCGCGCCGGAAAATCTGGCGCGCTTCGGCTTCCCGGTCTCGCGGGCCTTTGGCCAAAGACTGGCCGAT
TTGCCGCGCGGCCCGGGGGTGGATCGGCGATTGAGCGCCCGCTTCGCCGGGGTCAGCGAGGGGGGGCGGTATAGCGACGT
CGATCTGGCCGGTCTGATCGGCCGCCTGCGCCAGCGTGGCCCGGGCGAGATGCACGACGGCCAACTGGCCCGTGAAATCG
CTCAGGCCGCCCAGGCCGAGGGCATCGGCCTGACCGTCGAGGACCTGCGCCGCCAGTTGCCGCGCTGGCTGCCGACCACC
ACCGCCGAGCGCGGCAACGAGATCGTTCACACCGCCACCACCCCGGGCGCCGCCGGGGGATCGGGCGGCGCGGCGCCGGG
CGCCACCGGCTTTGTCGTGGCCGACAGCTATGGCAACGCGGTGTCTTGCGCCCTGACCCTGGGGCGGCCCTTTGGCAGTG
GCAGGATCATGCCCAATCAGGGCTTCGTGCTGGCCGATGCCAGCGCCGTGGCCGGGGGGGGCGAGGCTTTGGCCACCTTG
CTGATGATCAACCCCAATGTGCACGAGTTCCATCTGGCGATCGCCGGCGCCGGCGCCGGGGCGGCCGCCCTGCAAAGCGC
CGTCGCCCGCCCCTTGCTCGAGAATGAGGGCGATGCGCAAGCCGCGATCGCCGGGGCGATCTCCGCCGTGGCCAGCGGGG
CGCGGGTCAATGTCGCCTCGTGCCCCCAGGGTATTCCGCCCAAACCGGCCTCGTGCCGGGCGGCGACCGATCCCCGGGGG
GCTGGCTATGCCCTGAGGGCGGGCAGCTAA

Upstream 100 bases:

>100_bases
CATGATCTCCATAGACCGGATGTTTCCCCAAGCTAAGGGGCGGCGGCGGGTCCGTCAACGCGCCCGCCGGTCTGTTCTGG
CCGTTCTTGCCGCGGGAAGT

Downstream 100 bases:

>100_bases
AAGCACCCTGGGTTCCCTTTTGCCTTTTTTTGCATGGCCCTCTTTTGCGTGGAATGTGGTTCGATGGCTTTGAAAGTGGC
CCGGCGGGGCCTTATTCCGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MVAGCADDRQIGVVGYIEGFSGVVAADEPQAVLAGRDILSAGGRAADAAVAMAFTLAVTLPSAAGLGGGGLCVVYDAKAN
KAETLDFLPGPASGGMAAYGAPGGAFGGGRAVAVPALGRGMFALNAKYGTLRWEGLLAAPENLARFGFPVSRAFGQRLAD
LPRGPGVDRRLSARFAGVSEGGRYSDVDLAGLIGRLRQRGPGEMHDGQLAREIAQAAQAEGIGLTVEDLRRQLPRWLPTT
TAERGNEIVHTATTPGAAGGSGGAAPGATGFVVADSYGNAVSCALTLGRPFGSGRIMPNQGFVLADASAVAGGGEALATL
LMINPNVHEFHLAIAGAGAGAAALQSAVARPLLENEGDAQAAIAGAISAVASGARVNVASCPQGIPPKPASCRAATDPRG
AGYALRAGS

Sequences:

>Translated_409_residues
MVAGCADDRQIGVVGYIEGFSGVVAADEPQAVLAGRDILSAGGRAADAAVAMAFTLAVTLPSAAGLGGGGLCVVYDAKAN
KAETLDFLPGPASGGMAAYGAPGGAFGGGRAVAVPALGRGMFALNAKYGTLRWEGLLAAPENLARFGFPVSRAFGQRLAD
LPRGPGVDRRLSARFAGVSEGGRYSDVDLAGLIGRLRQRGPGEMHDGQLAREIAQAAQAEGIGLTVEDLRRQLPRWLPTT
TAERGNEIVHTATTPGAAGGSGGAAPGATGFVVADSYGNAVSCALTLGRPFGSGRIMPNQGFVLADASAVAGGGEALATL
LMINPNVHEFHLAIAGAGAGAAALQSAVARPLLENEGDAQAAIAGAISAVASGARVNVASCPQGIPPKPASCRAATDPRG
AGYALRAGS
>Mature_409_residues
MVAGCADDRQIGVVGYIEGFSGVVAADEPQAVLAGRDILSAGGRAADAAVAMAFTLAVTLPSAAGLGGGGLCVVYDAKAN
KAETLDFLPGPASGGMAAYGAPGGAFGGGRAVAVPALGRGMFALNAKYGTLRWEGLLAAPENLARFGFPVSRAFGQRLAD
LPRGPGVDRRLSARFAGVSEGGRYSDVDLAGLIGRLRQRGPGEMHDGQLAREIAQAAQAEGIGLTVEDLRRQLPRWLPTT
TAERGNEIVHTATTPGAAGGSGGAAPGATGFVVADSYGNAVSCALTLGRPFGSGRIMPNQGFVLADASAVAGGGEALATL
LMINPNVHEFHLAIAGAGAGAAALQSAVARPLLENEGDAQAAIAGAISAVASGARVNVASCPQGIPPKPASCRAATDPRG
AGYALRAGS

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI73915090, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI73915096, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI73915094, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI113429324, Length=213, Percent_Identity=29.5774647887324, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI113429326, Length=222, Percent_Identity=28.3783783783784, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789856, Length=220, Percent_Identity=31.3636363636364, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17542894, Length=226, Percent_Identity=26.9911504424779, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859893, Length=216, Percent_Identity=30.0925925925926, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077880, Length=251, Percent_Identity=25.4980079681275, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551474, Length=251, Percent_Identity=25.4980079681275, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24642670, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24642666, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077878, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077496, Length=238, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 40588; Mature: 40588

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGCADDRQIGVVGYIEGFSGVVAADEPQAVLAGRDILSAGGRAADAAVAMAFTLAVTL
CCCCCCCCCCEEEEEEECCCCCEEECCCCCEEHHCCHHHHCCCCHHHHHHHHHHHHHHCC
PSAAGLGGGGLCVVYDAKANKAETLDFLPGPASGGMAAYGAPGGAFGGGRAVAVPALGRG
CCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCC
MFALNAKYGTLRWEGLLAAPENLARFGFPVSRAFGQRLADLPRGPGVDRRLSARFAGVSE
EEEEECCCCCEEEEEEEECCHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
GGRYSDVDLAGLIGRLRQRGPGEMHDGQLAREIAQAAQAEGIGLTVEDLRRQLPRWLPTT
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCC
TAERGNEIVHTATTPGAAGGSGGAAPGATGFVVADSYGNAVSCALTLGRPFGSGRIMPNQ
HHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCEECCCC
GFVLADASAVAGGGEALATLLMINPNVHEFHLAIAGAGAGAAALQSAVARPLLENEGDAQ
CEEEECCCCCCCCHHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCHH
AAIAGAISAVASGARVNVASCPQGIPPKPASCRAATDPRGAGYALRAGS
HHHHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MVAGCADDRQIGVVGYIEGFSGVVAADEPQAVLAGRDILSAGGRAADAAVAMAFTLAVTL
CCCCCCCCCCEEEEEEECCCCCEEECCCCCEEHHCCHHHHCCCCHHHHHHHHHHHHHHCC
PSAAGLGGGGLCVVYDAKANKAETLDFLPGPASGGMAAYGAPGGAFGGGRAVAVPALGRG
CCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCC
MFALNAKYGTLRWEGLLAAPENLARFGFPVSRAFGQRLADLPRGPGVDRRLSARFAGVSE
EEEEECCCCCEEEEEEEECCHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
GGRYSDVDLAGLIGRLRQRGPGEMHDGQLAREIAQAAQAEGIGLTVEDLRRQLPRWLPTT
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCC
TAERGNEIVHTATTPGAAGGSGGAAPGATGFVVADSYGNAVSCALTLGRPFGSGRIMPNQ
HHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCEECCCC
GFVLADASAVAGGGEALATLLMINPNVHEFHLAIAGAGAGAAALQSAVARPLLENEGDAQ
CEEEECCCCCCCCHHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCHH
AAIAGAISAVASGARVNVASCPQGIPPKPASCRAATDPRGAGYALRAGS
HHHHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]