Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 83593504

GI number: 83593504

Start: 2518196

End: 2518618

Strand: Reverse

Name: ndk

Synonym: Rru_A2169

Alternate gene names: 83593504

Gene position: 2518618-2518196 (Counterclockwise)

Preceding gene: 83593507

Following gene: 83593501

Centisome position: 57.86

GC content: 61.7

Gene sequence:

>423_bases
ATGGCGATCGAACGCACCCTCTCCATCATTAAGCCGGACGCGACCCGCCGCAATCTCACCGGGGCGATCAATGCCCGGTT
CGAGGAAGCGGGCCTGCGCATCGTCGGTCAGAAGCGTCTGCGCCTGACCACCGCCCAGGCGGAAGGCTTCTATGAGGTCC
ACAAGGAGCGCAGCTTCTTTGGCAGCCTCGTTGAATTCATGACCTCGGGCCCGGTGGTGGTTCAGGTTCTCGAAGGCGAG
AACGCGGTTCTGAAGAACCGTGAAGTGATGGGCGCCACCAACCCGGCCAACGCCGCCGAGCACACCATCCGCAAGGATTT
CGCCGAATCGATCGAAGCCAATTCGGTCCATGGGTCGGATTCCGCCGAGAACGCCGCCCACGAGATCGCTTACTTCTTCG
CCCAGACCGAAATCGTCGCCTAA

Upstream 100 bases:

>100_bases
GGGTCCCAAGCACGAACCCTCCGGACGCCGCAAGGGGCGGCGGGCCGTGATCAAGATAGAGCACCCTTTTCCGACGGACC
CCCAGCAAAGGGATACCAAA

Downstream 100 bases:

>100_bases
AGCAAATCCCCGAGCACTCTCGACCAGGGTGCGACGACGATTTGTGTCACTGCGAAACCCGCCCCGAAAGGGGCGGGTTT
TGTTTTGGGCCGCCGGCCGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFFGSLVEFMTSGPVVVQVLEGE
NAVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSDSAENAAHEIAYFFAQTEIVA

Sequences:

>Translated_140_residues
MAIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFFGSLVEFMTSGPVVVQVLEGE
NAVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSDSAENAAHEIAYFFAQTEIVA
>Mature_139_residues
AIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFFGSLVEFMTSGPVVVQVLEGEN
AVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSDSAENAAHEIAYFFAQTEIVA

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=44.5255474452555, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=44.5255474452555, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=44.5255474452555, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=44.5255474452555, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=44.5255474452555, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=44.5255474452555, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=44.5255474452555, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=42.3357664233577, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=40.8759124087591, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.0294117647059, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI30023828, Length=136, Percent_Identity=34.5588235294118, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=61.1510791366906, Blast_Score=176, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.9259259259259, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=39.7058823529412, Blast_Score=111, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=43.3823529411765, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=31.6176470588235, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_RHORT (Q2RSC6)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427256.1
- ProteinModelPortal:   Q2RSC6
- SMR:   Q2RSC6
- STRING:   Q2RSC6
- GeneID:   3835596
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2169
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q2RSC6
- ProtClustDB:   PRK00668
- BioCyc:   RRUB269796:RRU_A2169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15350; Mature: 15219

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFF
CCCHHHHHHCCCCCCCCCCCHHHCCEEHHCCEEEECCCEEEEEECCCCCHHHHHHHHHHH
GSLVEFMTSGPVVVQVLEGENAVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSD
HHHHHHHCCCCEEEEEECCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SAENAAHEIAYFFAQTEIVA
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIERTLSIIKPDATRRNLTGAINARFEEAGLRIVGQKRLRLTTAQAEGFYEVHKERSFF
CCHHHHHHCCCCCCCCCCCHHHCCEEHHCCEEEECCCEEEEEECCCCCHHHHHHHHHHH
GSLVEFMTSGPVVVQVLEGENAVLKNREVMGATNPANAAEHTIRKDFAESIEANSVHGSD
HHHHHHHCCCCEEEEEECCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SAENAAHEIAYFFAQTEIVA
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA