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The map label for this gene is ppx [H]

Identifier: 83593495

GI number: 83593495

Start: 2507901

End: 2509430

Strand: Reverse

Name: ppx [H]

Synonym: Rru_A2160

Alternate gene names: 83593495

Gene position: 2509430-2507901 (Counterclockwise)

Preceding gene: 83593496

Following gene: 83593493

Centisome position: 57.65

GC content: 66.73

Gene sequence:

>1530_bases
ATGACTGCGTCCGCCGCCTTCCCGCATGTTCCGGCCGCCCCGGTGGATCTTCGTCCGCTCGGGGTGGTCGATATCGGCTC
CAATTCCGTTCGCCTCGTCGTCTATCGCGGCCTCGCCCGCACCCCCATTCCGCTGTTCAACGAAAAAGCCACCTGCGCCC
TGGGCAAGGGCCTGGGCGAGACCGGCGTGCTCAATCCCGAAGGCGTCGCCCTGGCGCTGAAGGCGGTCAAGCGTTTCGCC
CATCTGGCGCGCCGCATGAACGTCGGCAAGCTGGAACTGGTGGCGACGGCGGCGGTGCGCGACGCCTGGGACGGCCGGGA
TTTCGTGCGCGCCCTGGAACGGGTGTCGGGGCTGCCGGTCAGCGTTCTCAGCGGCGAACAGGAAGCCAAGACCGCCGCGC
TCGGCGTGCTCTGCGGCTTGCCCGATGCCGATGGCATGGTCGCCGATCTTGGCGGCGGCTCGCTGGAACTGGTGATGCTT
GACCAGGGGCGCTTTGGCGATTTCGCCACCATGCCGCTGGGGATCTTGCGCCTGTCGGAAGCCTCCGATAACAGCCGCGT
GCGCGCCGTCGACATCATCGACGAGCATCTGGCGGGGCTGCCGTGGATTCCCAAGGGCCGGGGGCGGACGCTTTATGCGG
TGGGCGGCGCCTGGCGCAGTCTGGCCCGGGTCTGCATCGAACAGATGCACTATCCGCTTCATGTTCTCGATAATTTCGCC
ATTTCCCGGGTCGAGGCCCTGCGCCTGATCGAGGTTTTGTCGCGGCTGTCGCGCAAATCGCTGGAATCCATCCAGGGAAT
CAGCCGCAAGCGCCTGCCCCATTTGCCGATGGCGGCGGTGATTCTGGAACGCCTGCTTGAGGAGGTCCGTCCCGAGACCC
TGGTCTTCTCGGTGTACGGCATGCGCGAGGGCCGCTTCTTCCAGAACCTGCCGCCCGAGGTTCGGGTTCAAGATCCGCTG
ATCAGTTCGTGCAGCGAACTGGCGCGCAGCGCCGGCCGCTTCCCCGAGCACGGCGAGGAACTGATGGCCTGGATGGCGCC
GCTGCTGCCCAACGAAAGCGTCGAGCAGGCGCGCCTGCGCCGCGCCGCTTGTCTGATCAGCGATGTCTTTTGGTCAGAAC
ACCCCGATTATCGCGCCGATCAGGCCTTCCACCGGGTGCTCAAGCTGCCGTTCATGGGGCTCAACCATACCGACCGCGCC
GGCCTCGCCCTCACGGTTTACTATCGCTATACCAGCGAGGGAACCGACGACTGGGCCATGCGGGCGGCCTCCTTGCTTGA
CGAGACGCGGCTGAAGCGGGTGCGCATCATCGGCCATGCCCTGCGCCTGGGCCATACGGTCACCGGCGGCGCGCCGGGGC
TGCTTGGGCGCTCGGCCCTGTCGGCCAAGGACGGCGTCTTGACCTTCCATGTTCCCGAAGACGACCCGATTTTCCTGCCC
GAGGTCTTTGGCAAGCGCCTGGAAAAACTGGCGCGCGCCATGGGACTGGAGCCCAAACTCGCCCTCTTGCCCCCGGCCGC
GCAGGCGTAA

Upstream 100 bases:

>100_bases
GCGCTCAATGACCCTGAAAAGGACATTCCTACCCTGGAGGTTTCAGCTCAGAGGAACTAAGGTGCCGACCCCAGAGACCG
GTACCGGATCCCTTGCTGAC

Downstream 100 bases:

>100_bases
GGCCGGCGCGGCCGATCGGGCGGCTTTTAGCCCTTTAGGAAGTCGCCATAGGTGGTGGCGATGTAGTCGACGGCCACCTC
GACGAAACGGCCGCCCAATT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGETGVLNPEGVALALKAVKRFA
HLARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPVSVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVML
DQGRFGDFATMPLGILRLSEASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFA
ISRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYGMREGRFFQNLPPEVRVQDPL
ISSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLRRAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRA
GLALTVYYRYTSEGTDDWAMRAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLP
EVFGKRLEKLARAMGLEPKLALLPPAAQA

Sequences:

>Translated_509_residues
MTASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGETGVLNPEGVALALKAVKRFA
HLARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPVSVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVML
DQGRFGDFATMPLGILRLSEASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFA
ISRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYGMREGRFFQNLPPEVRVQDPL
ISSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLRRAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRA
GLALTVYYRYTSEGTDDWAMRAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLP
EVFGKRLEKLARAMGLEPKLALLPPAAQA
>Mature_508_residues
TASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGETGVLNPEGVALALKAVKRFAH
LARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPVSVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVMLD
QGRFGDFATMPLGILRLSEASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFAI
SRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYGMREGRFFQNLPPEVRVQDPLI
SSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLRRAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRAG
LALTVYYRYTSEGTDDWAMRAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLPE
VFGKRLEKLARAMGLEPKLALLPPAAQA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=137, Percent_Identity=33.5766423357664, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788848, Length=143, Percent_Identity=30.0699300699301, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55594; Mature: 55463

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGE
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCC
TGVLNPEGVALALKAVKRFAHLARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
SVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVMLDQGRFGDFATMPLGILRLSE
EECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHCCHHHEEEEC
ASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFA
CCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
ISRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
MREGRFFQNLPPEVRVQDPLISSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLR
CCCCCHHHCCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
RAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRAGLALTVYYRYTSEGTDDWAM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHH
RAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLP
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHCHHHCCCCCCEEEEECCCCCCEECH
EVFGKRLEKLARAMGLEPKLALLPPAAQA
HHHHHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure 
TASAAFPHVPAAPVDLRPLGVVDIGSNSVRLVVYRGLARTPIPLFNEKATCALGKGLGE
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCC
TGVLNPEGVALALKAVKRFAHLARRMNVGKLELVATAAVRDAWDGRDFVRALERVSGLPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
SVLSGEQEAKTAALGVLCGLPDADGMVADLGGGSLELVMLDQGRFGDFATMPLGILRLSE
EECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHCCHHHEEEEC
ASDNSRVRAVDIIDEHLAGLPWIPKGRGRTLYAVGGAWRSLARVCIEQMHYPLHVLDNFA
CCCCCCEEEEEHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
ISRVEALRLIEVLSRLSRKSLESIQGISRKRLPHLPMAAVILERLLEEVRPETLVFSVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
MREGRFFQNLPPEVRVQDPLISSCSELARSAGRFPEHGEELMAWMAPLLPNESVEQARLR
CCCCCHHHCCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
RAACLISDVFWSEHPDYRADQAFHRVLKLPFMGLNHTDRAGLALTVYYRYTSEGTDDWAM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHH
RAASLLDETRLKRVRIIGHALRLGHTVTGGAPGLLGRSALSAKDGVLTFHVPEDDPIFLP
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHCHHHCCCCCCEEEEECCCCCCEECH
EVFGKRLEKLARAMGLEPKLALLPPAAQA
HHHHHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]