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The map label for this gene is rkpK [H]

Identifier: 83593451

GI number: 83593451

Start: 2456149

End: 2457465

Strand: Reverse

Name: rkpK [H]

Synonym: Rru_A2116

Alternate gene names: 83593451

Gene position: 2457465-2456149 (Counterclockwise)

Preceding gene: 83593452

Following gene: 83593450

Centisome position: 56.46

GC content: 63.86

Gene sequence:

>1317_bases
ATGCGTATCGCGATGATCGGCACCGGCTATGTGGGTTTGGTGTCGGGCGCCTGTTTTTCCGAATTCGGCGTTGATGTGGT
CTGCGTCGACAAGGACGTCCGCAAGATCGACGGTCTGCGCGAGCGCGGCGAGATCCCCATCTACGAGCCGGGTCTTGATG
CCCTGGTGGCATCCAACACCGCCGCTGGACGGCTGTCGTTCACCACCGACCTCAAGGAGGCGATGGCCGGAGCGGACGCG
GTGTTCATCGCCGTGGGAACGCCAAGCCGGCGCGGCGATGGTCACGCCGATCTGTCCTATGTCTATAACGCCGCCCGCGA
AGTCGCCGAGCATATGGACCGCTACACGGTGGTGGTGACCAAATCGACGGTGCCGGTGGGTACCGGGCGCGAAGTGGCGC
GGATCATCCGCGAAGCCAATCCCGCGGCCGATTTCGACGTGGTCTCCAATCCCGAATTCCTGCGCGAGGGCTCGGCGATC
AACGATTTCATGCGCCCCGACCGCGTGGTCATCGGCGCCGAGACCGAACGCGCCCAGGCGGTGATGCGCCAGCTTTACCG
GGTGCTCTATCTGATCGAAACGCCGATCCTGTTCACGGCGCTTGAAACCTCGGAACTGATCAAATACGCCGCCAATACCT
TCCTCGCCACCAAGATCACCTTCATCAACGAGATCGCCGATCTGTGCGAGAAGGTCGGGGCCGACGTTCATGACGTCGCC
CGCGGCATCGGTCTGGATGGGCGGATCGGCCGCAAGTTCCTGCATGCCGGCCCGGGCTATGGCGGGTCGTGCTTCCCCAA
GGATACCCTGGCGCTGGTCAAGACCGCCCAGGATTTCGGCGCGCCGCTGCGCATCATTGAAACCGTGGTCTCGATCAACG
ACCAGCGCAAGAAGGCGATGGCGGACAAGGTGGTCCAGTTCCTGGGCGGCGACGTCACGGGCAAGACCATCGCCGTCCTC
GGGCTGACCTTCAAGCCCAATACGGACGACATGCGCGACAGCCCCAGCCTGGACATCGTTCCCGCCCTGCAGCGGGCCGG
CGCCACCATCCGCGCCTTCGATCCCGAGGGCATGCACGAGGCGGCCAAGCATTTCACCGATGTTCTGTATGCCGAAAGCG
CCTATGACTGCATGGCCGGCGCCGATGCCCTGGTGATTTTGACCGAATGGAACGAGTTCCGCGCCCTTGATCTCGACCGG
GTCAAGACCCTGCTCAAGGCGCCGGTGCTGATCGATCTGCGCAACATCTATAACCCCGACGACATGGAGGCCCAGGGCTT
CCGCTATAGCCCGATCGGCCGCCGCTCGGTGGGCTGA

Upstream 100 bases:

>100_bases
CGCCGTGAAGGCCGTTCTCGCCGATTTCGCCAAGACCATCTGATCTCTCTTCCGGGCGGCGGGTTCCGCCGCCCGTTTCG
CTGTTCAAGGGGAGCCTCCC

Downstream 100 bases:

>100_bases
TCCGTCGGGAAGCCTGTCTTTTCCAGGGGGAGTGCTGTTCCATGACCGTCACGGTTCTGGAGGTTCCAACCACGCCGTTC
GCCGGGCAGAAACCCGGAAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRIAMIGTGYVGLVSGACFSEFGVDVVCVDKDVRKIDGLRERGEIPIYEPGLDALVASNTAAGRLSFTTDLKEAMAGADA
VFIAVGTPSRRGDGHADLSYVYNAAREVAEHMDRYTVVVTKSTVPVGTGREVARIIREANPAADFDVVSNPEFLREGSAI
NDFMRPDRVVIGAETERAQAVMRQLYRVLYLIETPILFTALETSELIKYAANTFLATKITFINEIADLCEKVGADVHDVA
RGIGLDGRIGRKFLHAGPGYGGSCFPKDTLALVKTAQDFGAPLRIIETVVSINDQRKKAMADKVVQFLGGDVTGKTIAVL
GLTFKPNTDDMRDSPSLDIVPALQRAGATIRAFDPEGMHEAAKHFTDVLYAESAYDCMAGADALVILTEWNEFRALDLDR
VKTLLKAPVLIDLRNIYNPDDMEAQGFRYSPIGRRSVG

Sequences:

>Translated_438_residues
MRIAMIGTGYVGLVSGACFSEFGVDVVCVDKDVRKIDGLRERGEIPIYEPGLDALVASNTAAGRLSFTTDLKEAMAGADA
VFIAVGTPSRRGDGHADLSYVYNAAREVAEHMDRYTVVVTKSTVPVGTGREVARIIREANPAADFDVVSNPEFLREGSAI
NDFMRPDRVVIGAETERAQAVMRQLYRVLYLIETPILFTALETSELIKYAANTFLATKITFINEIADLCEKVGADVHDVA
RGIGLDGRIGRKFLHAGPGYGGSCFPKDTLALVKTAQDFGAPLRIIETVVSINDQRKKAMADKVVQFLGGDVTGKTIAVL
GLTFKPNTDDMRDSPSLDIVPALQRAGATIRAFDPEGMHEAAKHFTDVLYAESAYDCMAGADALVILTEWNEFRALDLDR
VKTLLKAPVLIDLRNIYNPDDMEAQGFRYSPIGRRSVG
>Mature_438_residues
MRIAMIGTGYVGLVSGACFSEFGVDVVCVDKDVRKIDGLRERGEIPIYEPGLDALVASNTAAGRLSFTTDLKEAMAGADA
VFIAVGTPSRRGDGHADLSYVYNAAREVAEHMDRYTVVVTKSTVPVGTGREVARIIREANPAADFDVVSNPEFLREGSAI
NDFMRPDRVVIGAETERAQAVMRQLYRVLYLIETPILFTALETSELIKYAANTFLATKITFINEIADLCEKVGADVHDVA
RGIGLDGRIGRKFLHAGPGYGGSCFPKDTLALVKTAQDFGAPLRIIETVVSINDQRKKAMADKVVQFLGGDVTGKTIAVL
GLTFKPNTDDMRDSPSLDIVPALQRAGATIRAFDPEGMHEAAKHFTDVLYAESAYDCMAGADALVILTEWNEFRALDLDR
VKTLLKAPVLIDLRNIYNPDDMEAQGFRYSPIGRRSVG

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=37.7969762419007, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI296040438, Length=363, Percent_Identity=38.8429752066116, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI296040443, Length=310, Percent_Identity=39.3548387096774, Blast_Score=201, Evalue=9e-52,
Organism=Escherichia coli, GI48994968, Length=419, Percent_Identity=31.5035799522673, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1788340, Length=355, Percent_Identity=31.2676056338028, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=37.4193548387097, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=37.4458874458874, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47635; Mature: 47635

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAMIGTGYVGLVSGACFSEFGVDVVCVDKDVRKIDGLRERGEIPIYEPGLDALVASNT
CEEEEEECCHHHHHCCHHHHHHCCEEEEECCHHHHHHCHHHCCCCCCCCCCCHHHHCCCC
AAGRLSFTTDLKEAMAGADAVFIAVGTPSRRGDGHADLSYVYNAAREVAEHMDRYTVVVT
CCCEEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
KSTVPVGTGREVARIIREANPAADFDVVSNPEFLREGSAINDFMRPDRVVIGAETERAQA
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHCCCCEEEEECCHHHHHH
VMRQLYRVLYLIETPILFTALETSELIKYAANTFLATKITFINEIADLCEKVGADVHDVA
HHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RGIGLDGRIGRKFLHAGPGYGGSCFPKDTLALVKTAQDFGAPLRIIETVVSINDQRKKAM
HHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHH
ADKVVQFLGGDVTGKTIAVLGLTFKPNTDDMRDSPSLDIVPALQRAGATIRAFDPEGMHE
HHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCHHH
AAKHFTDVLYAESAYDCMAGADALVILTEWNEFRALDLDRVKTLLKAPVLIDLRNIYNPD
HHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCHHCCCHHHHHHHHHCCCEEEHHHCCCCC
DMEAQGFRYSPIGRRSVG
CCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRIAMIGTGYVGLVSGACFSEFGVDVVCVDKDVRKIDGLRERGEIPIYEPGLDALVASNT
CEEEEEECCHHHHHCCHHHHHHCCEEEEECCHHHHHHCHHHCCCCCCCCCCCHHHHCCCC
AAGRLSFTTDLKEAMAGADAVFIAVGTPSRRGDGHADLSYVYNAAREVAEHMDRYTVVVT
CCCEEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
KSTVPVGTGREVARIIREANPAADFDVVSNPEFLREGSAINDFMRPDRVVIGAETERAQA
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHCCCCEEEEECCHHHHHH
VMRQLYRVLYLIETPILFTALETSELIKYAANTFLATKITFINEIADLCEKVGADVHDVA
HHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RGIGLDGRIGRKFLHAGPGYGGSCFPKDTLALVKTAQDFGAPLRIIETVVSINDQRKKAM
HHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHH
ADKVVQFLGGDVTGKTIAVLGLTFKPNTDDMRDSPSLDIVPALQRAGATIRAFDPEGMHE
HHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCHHH
AAKHFTDVLYAESAYDCMAGADALVILTEWNEFRALDLDRVKTLLKAPVLIDLRNIYNPD
HHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCHHCCCHHHHHHHHHCCCEEEHHHCCCCC
DMEAQGFRYSPIGRRSVG
CCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]