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The map label for this gene is rnd [H]

Identifier: 83593408

GI number: 83593408

Start: 2399339

End: 2400499

Strand: Direct

Name: rnd [H]

Synonym: Rru_A2073

Alternate gene names: 83593408

Gene position: 2399339-2400499 (Clockwise)

Preceding gene: 83593406

Following gene: 83593410

Centisome position: 55.12

GC content: 65.46

Gene sequence:

>1161_bases
ATGCCCTTGATTTCCACCACCAAAGACCTCGCCGATTTTTGTGCCAGGCTGTCCACCGAGTCCTTCGTGACCGTGGACAC
AGAATTCATGCGCGAAAAGACCTATTGGCCCAAGCTGTGCCTGATCCAGCTTGCCGGCACCACGGAGGCCCATTGCGTGG
ACCCCCTGGCGCCCGACATCGACATGGCGCCGCTGTTCGCCTTGATGGCCAATGAAAGCGTGCTGAAGGTTTTTCATGCC
GCCCGCCAGGATCTGGAGATCTTTCTCCATGAATCGGGCCATCTGCCCAAGCCGATCTTCGATACCCAGGTCGCCGCCAT
GGTCTGCGGCTTTGGCGATTCGGTCGGCTATGAAACCCTGGTCGCCAAGCTGGCGAAAGCGCGGATCGATAAATCCATGC
GCTTCACCGACTGGGCGCGCCGCCCCTTGAACGACCGCCAGTTGGTCTATGCCGCCGGCGACGTCACCCATCTGCGCGTC
GTCTACGAGCGTCTGGCCGAGACCCTGGCCGCCAATGGCCGCACGGCCTGGCTGGACCAGGAGATGGCCATCCTGACCGA
TCCGGCCCATTACCGGGTCGAACCGGAAGACGCCTGGATGCGGATCAAGGCGCGCTCGCGCTCGGCCCGCTTCCTCGCCC
TGCTCCAGGAACTGGCGGCTTGGCGCGAGCGGACCGCCCAGGAACGCGATCTGCCGCGCAACCGGGTGATGCGCGACGAA
GGCCTGCTGGAAATCGCCGCCAGCGCCCCGACCACCCCCGACGCCCTGTCGCAGCTGCGCAGCGTGTCCAAGGGCATGGC
CGAAGGCACCATGGGTTTGGGGATCCTGGAGGCCGTGCGCCTTGCCCAGGCGATCCCCGAAAAGGCCCTGCCCCACCCGC
CCGACCGCGAAGACCTGCCCCAGGGGCTGGGTCCGGTGGTCGATCTGCTCAAGGTGCTTCTGAAAATGAAGTGCGAGGAG
GCCGGGGTGGCGCAGAAGCTGGTCGCCAATATGAACGACCTTGAACGCATCGCCGCCGATGACAACGCCGATGTCCTGGC
GATGGAGGGCTGGCGCCGCGCCCTGTTTGGCGAGGACGCCCTGCGCCTTAAGCACGGCCACCTCGCCATCGCCCTAACCG
CCGACGGCCAGGGCCTGCGCGTCATCCCGCTCAGCAACTAA

Upstream 100 bases:

>100_bases
GGGCCGGAAAGGGTACCGGAAGGGACACCCTTGAGCGCCTTTTGTCAAGTCGGCGAGGCACCCCCTTGCCGACCGCGCCG
GAGCGGGATACAACCTTCCT

Downstream 100 bases:

>100_bases
TAAGCCGCCCGCTCCCAAAGCGGCCGGCCGCCTTTCGCGGCCTGAGAGCGGTGAGCGGGGAACTCTGGTTCCCGCTCACC
GCTCTCAGATCTTGATGGTC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPLISTTKDLADFCARLSTESFVTVDTEFMREKTYWPKLCLIQLAGTTEAHCVDPLAPDIDMAPLFALMANESVLKVFHA
ARQDLEIFLHESGHLPKPIFDTQVAAMVCGFGDSVGYETLVAKLAKARIDKSMRFTDWARRPLNDRQLVYAAGDVTHLRV
VYERLAETLAANGRTAWLDQEMAILTDPAHYRVEPEDAWMRIKARSRSARFLALLQELAAWRERTAQERDLPRNRVMRDE
GLLEIAASAPTTPDALSQLRSVSKGMAEGTMGLGILEAVRLAQAIPEKALPHPPDREDLPQGLGPVVDLLKVLLKMKCEE
AGVAQKLVANMNDLERIAADDNADVLAMEGWRRALFGEDALRLKHGHLAIALTADGQGLRVIPLSN

Sequences:

>Translated_386_residues
MPLISTTKDLADFCARLSTESFVTVDTEFMREKTYWPKLCLIQLAGTTEAHCVDPLAPDIDMAPLFALMANESVLKVFHA
ARQDLEIFLHESGHLPKPIFDTQVAAMVCGFGDSVGYETLVAKLAKARIDKSMRFTDWARRPLNDRQLVYAAGDVTHLRV
VYERLAETLAANGRTAWLDQEMAILTDPAHYRVEPEDAWMRIKARSRSARFLALLQELAAWRERTAQERDLPRNRVMRDE
GLLEIAASAPTTPDALSQLRSVSKGMAEGTMGLGILEAVRLAQAIPEKALPHPPDREDLPQGLGPVVDLLKVLLKMKCEE
AGVAQKLVANMNDLERIAADDNADVLAMEGWRRALFGEDALRLKHGHLAIALTADGQGLRVIPLSN
>Mature_385_residues
PLISTTKDLADFCARLSTESFVTVDTEFMREKTYWPKLCLIQLAGTTEAHCVDPLAPDIDMAPLFALMANESVLKVFHAA
RQDLEIFLHESGHLPKPIFDTQVAAMVCGFGDSVGYETLVAKLAKARIDKSMRFTDWARRPLNDRQLVYAAGDVTHLRVV
YERLAETLAANGRTAWLDQEMAILTDPAHYRVEPEDAWMRIKARSRSARFLALLQELAAWRERTAQERDLPRNRVMRDEG
LLEIAASAPTTPDALSQLRSVSKGMAEGTMGLGILEAVRLAQAIPEKALPHPPDREDLPQGLGPVVDLLKVLLKMKCEEA
GVAQKLVANMNDLERIAADDNADVLAMEGWRRALFGEDALRLKHGHLAIALTADGQGLRVIPLSN

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=269, Percent_Identity=23.7918215613383, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI50301240, Length=269, Percent_Identity=23.7918215613383, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788105, Length=367, Percent_Identity=36.2397820163488, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17531757, Length=259, Percent_Identity=26.2548262548263, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=313, Percent_Identity=24.2811501597444, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078302, Length=257, Percent_Identity=26.0700389105058, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42808; Mature: 42677

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLISTTKDLADFCARLSTESFVTVDTEFMREKTYWPKLCLIQLAGTTEAHCVDPLAPDI
CCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
DMAPLFALMANESVLKVFHAARQDLEIFLHESGHLPKPIFDTQVAAMVCGFGDSVGYETL
CHHHHHHHHHCHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
VAKLAKARIDKSMRFTDWARRPLNDRQLVYAAGDVTHLRVVYERLAETLAANGRTAWLDQ
HHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECC
EMAILTDPAHYRVEPEDAWMRIKARSRSARFLALLQELAAWRERTAQERDLPRNRVMRDE
CHHEEECCCCEEECCHHHHEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLLEIAASAPTTPDALSQLRSVSKGMAEGTMGLGILEAVRLAQAIPEKALPHPPDREDLP
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QGLGPVVDLLKVLLKMKCEEAGVAQKLVANMNDLERIAADDNADVLAMEGWRRALFGEDA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEHHHHHHHHCCCHH
LRLKHGHLAIALTADGQGLRVIPLSN
HEEECCCEEEEEEECCCCEEEEECCC
>Mature Secondary Structure 
PLISTTKDLADFCARLSTESFVTVDTEFMREKTYWPKLCLIQLAGTTEAHCVDPLAPDI
CCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
DMAPLFALMANESVLKVFHAARQDLEIFLHESGHLPKPIFDTQVAAMVCGFGDSVGYETL
CHHHHHHHHHCHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
VAKLAKARIDKSMRFTDWARRPLNDRQLVYAAGDVTHLRVVYERLAETLAANGRTAWLDQ
HHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECC
EMAILTDPAHYRVEPEDAWMRIKARSRSARFLALLQELAAWRERTAQERDLPRNRVMRDE
CHHEEECCCCEEECCHHHHEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLLEIAASAPTTPDALSQLRSVSKGMAEGTMGLGILEAVRLAQAIPEKALPHPPDREDLP
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QGLGPVVDLLKVLLKMKCEEAGVAQKLVANMNDLERIAADDNADVLAMEGWRRALFGEDA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEHHHHHHHHCCCHH
LRLKHGHLAIALTADGQGLRVIPLSN
HEEECCCEEEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]