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The map label for this gene is nhaA [H]

Identifier: 83593390

GI number: 83593390

Start: 2377508

End: 2378302

Strand: Direct

Name: nhaA [H]

Synonym: Rru_A2055

Alternate gene names: 83593390

Gene position: 2377508-2378302 (Clockwise)

Preceding gene: 83593388

Following gene: 83593391

Centisome position: 54.62

GC content: 68.68

Gene sequence:

>795_bases
ATGCCCTTGTTTCCGCGCCGACGTCGAAGATTGGCCGTTCTGCGGCTGTCGGGTGTGATCGCCGCCCGCGACCGCGCCCT
GTCGCTCGCCGCCCTGAAACCGCTGATCGATCGCGCCTTTCGCGTCGGCGACGAGGTGGCCCTGGTCATCAACAGCCCCG
GCGGTTCGCCGGCCCAATCCCAGCTCATTCACGATTACATCCGGATCCAGGCCGATCGGCGCAAGAAGGCGGTGATCACC
TTCGTCGAAGACGTCGCGGCCTCGGGCGGCTATTGGATCGCCCTGGCCGGGGACAGCATCCGCGTGCTGCCGACCTCGTT
GGTCGGCTCGATCGGCGTGGTCAGCGCCGGCTTCGGCTTTGTCGAGGCCCTCGACCGTCTGGGGGTCGAGCGCCGTCTGG
TCGCCGCCGGGCGCAACAAGGTGCGCCTCGATCCGTTTTCGCCGCGCAAGGACGAAGACACCGAATGGCTGACCGGGCTG
CAGGCGCAGTTGCATGAGCGCTTCATCGAGCATGTGCGCTCGCGCCGCGCCGCCCAGGGCACCCGGCTTCCCGAAGGCGG
CGAGTTGTTCACCGGCGAGGTCTGGCTTGGTCGCGAGGCCATCGCCCATCGTCTGGCCGATCAGGAAGACAGTCTGGGCG
CCTATGTCGATCGCGAGAAGATACGCCTGCGCGAGATCGCGCCGCGGCGGATGTTCTCGCTGCGCGGCCTGATCGGCGGA
CTGGCGGCGGAAACCCTGGGCGCCCTGGAAGCCCGGATCGAGGACCGCGCCCTGCGCGCCCCCTTTGGCCTGTAA

Upstream 100 bases:

>100_bases
TCGGGCCGCTGGCGATGCGCCGCCTTGCGCCTTACATAGGCTTTCCGGCCCGCGCCGTTCCGCGCCGCCCGCCGCCCCCC
TTCGCCCGGAGAGACCCGCA

Downstream 100 bases:

>100_bases
GCGAAAGGACGGGCGGCGCGGCGCGCAAAAAGAAGCCGCTGGACGGCGGACGAAGAGCGGTCTAACACCGCCCGGCCATC
GACCAAGACAAGGTGATTCG

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MPLFPRRRRRLAVLRLSGVIAARDRALSLAALKPLIDRAFRVGDEVALVINSPGGSPAQSQLIHDYIRIQADRRKKAVIT
FVEDVAASGGYWIALAGDSIRVLPTSLVGSIGVVSAGFGFVEALDRLGVERRLVAAGRNKVRLDPFSPRKDEDTEWLTGL
QAQLHERFIEHVRSRRAAQGTRLPEGGELFTGEVWLGREAIAHRLADQEDSLGAYVDREKIRLREIAPRRMFSLRGLIGG
LAAETLGALEARIEDRALRAPFGL

Sequences:

>Translated_264_residues
MPLFPRRRRRLAVLRLSGVIAARDRALSLAALKPLIDRAFRVGDEVALVINSPGGSPAQSQLIHDYIRIQADRRKKAVIT
FVEDVAASGGYWIALAGDSIRVLPTSLVGSIGVVSAGFGFVEALDRLGVERRLVAAGRNKVRLDPFSPRKDEDTEWLTGL
QAQLHERFIEHVRSRRAAQGTRLPEGGELFTGEVWLGREAIAHRLADQEDSLGAYVDREKIRLREIAPRRMFSLRGLIGG
LAAETLGALEARIEDRALRAPFGL
>Mature_263_residues
PLFPRRRRRLAVLRLSGVIAARDRALSLAALKPLIDRAFRVGDEVALVINSPGGSPAQSQLIHDYIRIQADRRKKAVITF
VEDVAASGGYWIALAGDSIRVLPTSLVGSIGVVSAGFGFVEALDRLGVERRLVAAGRNKVRLDPFSPRKDEDTEWLTGLQ
AQLHERFIEHVRSRRAAQGTRLPEGGELFTGEVWLGREAIAHRLADQEDSLGAYVDREKIRLREIAPRRMFSLRGLIGGL
AAETLGALEARIEDRALRAPFGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788064, Length=181, Percent_Identity=29.8342541436464, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 29112; Mature: 28981

Theoretical pI: Translated: 11.08; Mature: 11.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFPRRRRRLAVLRLSGVIAARDRALSLAALKPLIDRAFRVGDEVALVINSPGGSPAQS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
QLIHDYIRIQADRRKKAVITFVEDVAASGGYWIALAGDSIRVLPTSLVGSIGVVSAGFGF
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCHHH
VEALDRLGVERRLVAAGRNKVRLDPFSPRKDEDTEWLTGLQAQLHERFIEHVRSRRAAQG
HHHHHHHCHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TRLPEGGELFTGEVWLGREAIAHRLADQEDSLGAYVDREKIRLREIAPRRMFSLRGLIGG
CCCCCCCCEEECCEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAETLGALEARIEDRALRAPFGL
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLFPRRRRRLAVLRLSGVIAARDRALSLAALKPLIDRAFRVGDEVALVINSPGGSPAQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
QLIHDYIRIQADRRKKAVITFVEDVAASGGYWIALAGDSIRVLPTSLVGSIGVVSAGFGF
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCHHH
VEALDRLGVERRLVAAGRNKVRLDPFSPRKDEDTEWLTGLQAQLHERFIEHVRSRRAAQG
HHHHHHHCHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TRLPEGGELFTGEVWLGREAIAHRLADQEDSLGAYVDREKIRLREIAPRRMFSLRGLIGG
CCCCCCCCEEECCEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAETLGALEARIEDRALRAPFGL
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA