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The map label for this gene is yngE [H]

Identifier: 83593278

GI number: 83593278

Start: 2251271

End: 2252878

Strand: Reverse

Name: yngE [H]

Synonym: Rru_A1943

Alternate gene names: 83593278

Gene position: 2252878-2251271 (Counterclockwise)

Preceding gene: 83593279

Following gene: 83593277

Centisome position: 51.76

GC content: 65.49

Gene sequence:

>1608_bases
GTGAGCGTGATCAGAAGCGCGATCGATCCGCATGGGGCCGATTTCCGCGCCAACCATCTGAAGATGACCGCCCTGGTCGA
CGATCTGAAACGTCAGGTGGCGACGATCAAGGCCGGGGGCGGTGCCGCCGCCCGCGAAAGGCACGAGGGACGCGGCAAGC
TGTTGCCGCGCGAACGCGTGCGCGCCTTGCTTGATATCGGCTCGCCCTTCCTGGAGATCGGCCAGTTCGCCGCCCATGGC
GTCTATGACGATGCCGTGCCGGCCGCCGGCCTGATCGCCGGGATCGGCCGCATTGAGGGCGTGGACTGCGTGGTCGTCGC
CAATGACGCCACGGTCAAGGGCGGCACCTATTATCCGCTGACCGTCAAAAAGCACCTGCGCGCCCAGGAGATCGCCGGCG
AGAACAACTTGCCTTGCGTCTATCTGGTCGATTCCGGCGGTGCTTTTCTGCCGCGCCAGGACGAGGTCTTTCCCGATCGC
GATCACTTCGGCCGGATTTTCTATAATCAGGCGATGCTGAGCGCGGCGGGCATTCCGCAGATCGCCGTGGTCATGGGCAG
TTGCACGGCCGGTGGCGCCTATGTTCCGGCGATGTGCGACGAGGCGATCATCGTGCGCGACCAGGGCACCATCTTTCTCG
GCGGTCCGCCGCTGGTCCGCGCCGCCACCGGCGAGGTGGTTTCGGCCGAGGACCTGGGCGGCGCCGATGTCCATTGCAGG
ATTTCCGGGGTGACCGACCATTACGCCGAGGATGACCGCCACGCCCTGGCCCTGGCGCGCCGCGTCGTCGCCACCCTCAA
TCGCACCAAACGCGTCGGGCTGGCCCTGCGTCCGCCCGAAGAGCCGCTGTATGATCCGGCCGAGCTTTACGGCATCATCC
CCACCGATACCCGCAAGCCCTATGACGTGCGCGAGGTCATCGCCCGCCTAGTCGATGGGTCGCGCCTTGACGCCTTCAAG
GCGCTATACGGGCCGACGCTGGTTTGCGGCTTCGCCCATGTCTTTGGCTATCCGGTGGGGGTGGTCGCCAATAACGGCAT
TCTGTTTGGCGACGCCGCGCGCAAGGGGGCCCATTTCGTCGAACTCTGCGCCAAACGCGCCATCCCTTTGATTTTCCTTC
AAAACATCAGCGGCTTCATGGTTGGCCGCAAGGCCGAAAGCGCCGGCATCGCCCGCGATGGCGCCAAGATGGTGACCGCC
GTCGCCTGCGCCCGGGTGCCCAAGTTCACCGTGTTGATCGGCGGGTCGTTCGGAGCGGGCAATTACGCCATGTGCGGAAG
GGGATATGGTCCGCGCCTGCTGTGGAGCTGGCCCAACAGCCGCATCTCGGTGATGGGCGGCGAACAGGCGGCCACCGTGT
TGGCCCAGGTTCGCCGCGACGCCCTGGAAAGCCAGGGAACGCCTTGGTCGGAGGTCGAGGAGGAGGCCTTCAAACAGCCG
CTGCGCGCCCAATACGAAACCCAGGGACATCCCTATTACGCCAGTGCCCGGTTGTGGGATGACGGGATCGTCGATCCCGT
CGATACCCGGATGGTTCTCGGGCTGTCGATCTCCGCCGCTCTCAACGCCCCCGTTGCCGAAACGACGTTCGGCGTCTTTC
GCATGTGA

Upstream 100 bases:

>100_bases
AACCGGCGCCGGCCTTTTTGGCGCGGCGGACCGATGACAGAGTGCCGCGAATCATCGCCAAGGAGCCCGATTAAAGGGCC
GGTCAGGGGAGGGGAGCGTT

Downstream 100 bases:

>100_bases
GGAGTTCCGAGTCATGGATCTGCTTGTTGAAACGGTTGAACCCCGGGGGGTGGTCCGCTTGACGCTGAACCGTCCCGAGG
TGCGCAACGCCTTTGACGAC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSVIRSAIDPHGADFRANHLKMTALVDDLKRQVATIKAGGGAAARERHEGRGKLLPRERVRALLDIGSPFLEIGQFAAHG
VYDDAVPAAGLIAGIGRIEGVDCVVVANDATVKGGTYYPLTVKKHLRAQEIAGENNLPCVYLVDSGGAFLPRQDEVFPDR
DHFGRIFYNQAMLSAAGIPQIAVVMGSCTAGGAYVPAMCDEAIIVRDQGTIFLGGPPLVRAATGEVVSAEDLGGADVHCR
ISGVTDHYAEDDRHALALARRVVATLNRTKRVGLALRPPEEPLYDPAELYGIIPTDTRKPYDVREVIARLVDGSRLDAFK
ALYGPTLVCGFAHVFGYPVGVVANNGILFGDAARKGAHFVELCAKRAIPLIFLQNISGFMVGRKAESAGIARDGAKMVTA
VACARVPKFTVLIGGSFGAGNYAMCGRGYGPRLLWSWPNSRISVMGGEQAATVLAQVRRDALESQGTPWSEVEEEAFKQP
LRAQYETQGHPYYASARLWDDGIVDPVDTRMVLGLSISAALNAPVAETTFGVFRM

Sequences:

>Translated_535_residues
MSVIRSAIDPHGADFRANHLKMTALVDDLKRQVATIKAGGGAAARERHEGRGKLLPRERVRALLDIGSPFLEIGQFAAHG
VYDDAVPAAGLIAGIGRIEGVDCVVVANDATVKGGTYYPLTVKKHLRAQEIAGENNLPCVYLVDSGGAFLPRQDEVFPDR
DHFGRIFYNQAMLSAAGIPQIAVVMGSCTAGGAYVPAMCDEAIIVRDQGTIFLGGPPLVRAATGEVVSAEDLGGADVHCR
ISGVTDHYAEDDRHALALARRVVATLNRTKRVGLALRPPEEPLYDPAELYGIIPTDTRKPYDVREVIARLVDGSRLDAFK
ALYGPTLVCGFAHVFGYPVGVVANNGILFGDAARKGAHFVELCAKRAIPLIFLQNISGFMVGRKAESAGIARDGAKMVTA
VACARVPKFTVLIGGSFGAGNYAMCGRGYGPRLLWSWPNSRISVMGGEQAATVLAQVRRDALESQGTPWSEVEEEAFKQP
LRAQYETQGHPYYASARLWDDGIVDPVDTRMVLGLSISAALNAPVAETTFGVFRM
>Mature_534_residues
SVIRSAIDPHGADFRANHLKMTALVDDLKRQVATIKAGGGAAARERHEGRGKLLPRERVRALLDIGSPFLEIGQFAAHGV
YDDAVPAAGLIAGIGRIEGVDCVVVANDATVKGGTYYPLTVKKHLRAQEIAGENNLPCVYLVDSGGAFLPRQDEVFPDRD
HFGRIFYNQAMLSAAGIPQIAVVMGSCTAGGAYVPAMCDEAIIVRDQGTIFLGGPPLVRAATGEVVSAEDLGGADVHCRI
SGVTDHYAEDDRHALALARRVVATLNRTKRVGLALRPPEEPLYDPAELYGIIPTDTRKPYDVREVIARLVDGSRLDAFKA
LYGPTLVCGFAHVFGYPVGVVANNGILFGDAARKGAHFVELCAKRAIPLIFLQNISGFMVGRKAESAGIARDGAKMVTAV
ACARVPKFTVLIGGSFGAGNYAMCGRGYGPRLLWSWPNSRISVMGGEQAATVLAQVRRDALESQGTPWSEVEEEAFKQPL
RAQYETQGHPYYASARLWDDGIVDPVDTRMVLGLSISAALNAPVAETTFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=528, Percent_Identity=64.9621212121212, Blast_Score=720, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=30.7086614173228, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=29.5454545454545, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI310133460, Length=134, Percent_Identity=58.955223880597, Blast_Score=151, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=60.2996254681648, Blast_Score=690, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=31.8181818181818, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=31.8181818181818, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=62.431941923775, Blast_Score=723, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57284; Mature: 57153

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIRSAIDPHGADFRANHLKMTALVDDLKRQVATIKAGGGAAARERHEGRGKLLPRERV
CCCHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCHHHH
RALLDIGSPFLEIGQFAAHGVYDDAVPAAGLIAGIGRIEGVDCVVVANDATVKGGTYYPL
HHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIAGENNLPCVYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQAMLSAAGIPQ
EHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMCDEAIIVRDQGTIFLGGPPLVRAATGEVVSAEDLGGADVHCR
EEEEEECCCCCCEECHHHCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCEEEEE
ISGVTDHYAEDDRHALALARRVVATLNRTKRVGLALRPPEEPLYDPAELYGIIPTDTRKP
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVIARLVDGSRLDAFKALYGPTLVCGFAHVFGYPVGVVANNGILFGDAARKGAHFV
CCHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCEEEECCHHCCHHHH
ELCAKRAIPLIFLQNISGFMVGRKAESAGIARDGAKMVTAVACARVPKFTVLIGGSFGAG
HHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYAMCGRGYGPRLLWSWPNSRISVMGGEQAATVLAQVRRDALESQGTPWSEVEEEAFKQP
CEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
LRAQYETQGHPYYASARLWDDGIVDPVDTRMVLGLSISAALNAPVAETTFGVFRM
HHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SVIRSAIDPHGADFRANHLKMTALVDDLKRQVATIKAGGGAAARERHEGRGKLLPRERV
CCHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCHHHH
RALLDIGSPFLEIGQFAAHGVYDDAVPAAGLIAGIGRIEGVDCVVVANDATVKGGTYYPL
HHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIAGENNLPCVYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQAMLSAAGIPQ
EHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMCDEAIIVRDQGTIFLGGPPLVRAATGEVVSAEDLGGADVHCR
EEEEEECCCCCCEECHHHCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCEEEEE
ISGVTDHYAEDDRHALALARRVVATLNRTKRVGLALRPPEEPLYDPAELYGIIPTDTRKP
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVIARLVDGSRLDAFKALYGPTLVCGFAHVFGYPVGVVANNGILFGDAARKGAHFV
CCHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCEEEECCHHCCHHHH
ELCAKRAIPLIFLQNISGFMVGRKAESAGIARDGAKMVTAVACARVPKFTVLIGGSFGAG
HHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYAMCGRGYGPRLLWSWPNSRISVMGGEQAATVLAQVRRDALESQGTPWSEVEEEAFKQP
CEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
LRAQYETQGHPYYASARLWDDGIVDPVDTRMVLGLSISAALNAPVAETTFGVFRM
HHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]