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The map label for this gene is menB [H]

Identifier: 83593277

GI number: 83593277

Start: 2250430

End: 2251257

Strand: Reverse

Name: menB [H]

Synonym: Rru_A1942

Alternate gene names: 83593277

Gene position: 2251257-2250430 (Counterclockwise)

Preceding gene: 83593278

Following gene: 83593276

Centisome position: 51.72

GC content: 70.29

Gene sequence:

>828_bases
ATGGATCTGCTTGTTGAAACGGTTGAACCCCGGGGGGTGGTCCGCTTGACGCTGAACCGTCCCGAGGTGCGCAACGCCTT
TGACGACCGCCTGATCGCCGAGCTGACCGAGGCGGTTCTGCGCCATGGCCGTGATCCGGCGGTGCGGGTGATCGTGCTCG
CCGCCCAGGGCCGGGCCTTCAGCGCCGGCGCCGATCTGGGCTGGATGCGGCGGATGGCCGATTTCAGCCGCAGCGAGAAC
CTGATCGACGCCCTGGAACTCGCCCGCATGCTGCAGGTCATCGATCTTTGTCCCAAGCCGACCGTCGCCCTGGTCCAGGG
CGTGGCCTATGGCGGCGGGGTCGGGCTGGTGGCGGCCTGCGATATCGCCCTGGCCGCCGAGCCGGCGCTGTTTTGCCTGT
CGGAGGTGCGCCTGGGGCTGATTCCGGCGGTGATCTCGCCCTATGTCATCCGCGCCATCGGTCCGCGCGCCTGCCGCCGC
TTGTTCCTGACCGCCGAGACCTTTGGCGCCCAGCGCGCCCTCGGGCTGGGGCTGGTCAGCGACGTCGTCGCCGCCGATGC
CCTGGAAGGGGTGGCGGCGGCGGTGATCGCCGCCCTGCTCGCCGGCGCCCCCGAAGCCCAGAGCGAGGTCAAGGATCTGA
TCCGGCTGGTCGAGAACAGCGTGATGGACGAGGCGCTGTTGCGCGAGAGCGCGGTCCGCATCGCCGACCGCCGCTCCTCG
GACGAGGCGCGCGAGGGCATGGCCGCCTTTCTGGAAAAACGCTCGCCGGTCTGGATGACCCCCGACCCCGAGGGCGAGGA
GGCGCGCGCGTGTTTTCACGACTGCTGA

Upstream 100 bases:

>100_bases
GATACCCGGATGGTTCTCGGGCTGTCGATCTCCGCCGCTCTCAACGCCCCCGTTGCCGAAACGACGTTCGGCGTCTTTCG
CATGTGAGGAGTTCCGAGTC

Downstream 100 bases:

>100_bases
TCGCCAATCGCGGCGAGATCGCCTGTCGCATCGCCCGCACCGCCAAGCGCCTGGGGGTGGCGACGGTGGGGGTGTTTTCC
GACGCCGACGCCCAGAGCGC

Product: methylglutaconyl-CoA hydratase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDLLVETVEPRGVVRLTLNRPEVRNAFDDRLIAELTEAVLRHGRDPAVRVIVLAAQGRAFSAGADLGWMRRMADFSRSEN
LIDALELARMLQVIDLCPKPTVALVQGVAYGGGVGLVAACDIALAAEPALFCLSEVRLGLIPAVISPYVIRAIGPRACRR
LFLTAETFGAQRALGLGLVSDVVAADALEGVAAAVIAALLAGAPEAQSEVKDLIRLVENSVMDEALLRESAVRIADRRSS
DEAREGMAAFLEKRSPVWMTPDPEGEEARACFHDC

Sequences:

>Translated_275_residues
MDLLVETVEPRGVVRLTLNRPEVRNAFDDRLIAELTEAVLRHGRDPAVRVIVLAAQGRAFSAGADLGWMRRMADFSRSEN
LIDALELARMLQVIDLCPKPTVALVQGVAYGGGVGLVAACDIALAAEPALFCLSEVRLGLIPAVISPYVIRAIGPRACRR
LFLTAETFGAQRALGLGLVSDVVAADALEGVAAAVIAALLAGAPEAQSEVKDLIRLVENSVMDEALLRESAVRIADRRSS
DEAREGMAAFLEKRSPVWMTPDPEGEEARACFHDC
>Mature_275_residues
MDLLVETVEPRGVVRLTLNRPEVRNAFDDRLIAELTEAVLRHGRDPAVRVIVLAAQGRAFSAGADLGWMRRMADFSRSEN
LIDALELARMLQVIDLCPKPTVALVQGVAYGGGVGLVAACDIALAAEPALFCLSEVRLGLIPAVISPYVIRAIGPRACRR
LFLTAETFGAQRALGLGLVSDVVAADALEGVAAAVIAALLAGAPEAQSEVKDLIRLVENSVMDEALLRESAVRIADRRSS
DEAREGMAAFLEKRSPVWMTPDPEGEEARACFHDC

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) (Probable) [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=253, Percent_Identity=32.8063241106719, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI70995211, Length=186, Percent_Identity=36.5591397849462, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI31542718, Length=259, Percent_Identity=27.7992277992278, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI37594471, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI37594469, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45643119, Length=258, Percent_Identity=25.968992248062, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI260275230, Length=258, Percent_Identity=25.968992248062, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI260274832, Length=258, Percent_Identity=25.968992248062, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4502327, Length=256, Percent_Identity=32.8125, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI68989263, Length=217, Percent_Identity=30.4147465437788, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=24.8888888888889, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24.8888888888889, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787659, Length=246, Percent_Identity=32.520325203252, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=29.8804780876494, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=31.6205533596838, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787660, Length=263, Percent_Identity=33.4600760456274, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=28.735632183908, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790281, Length=193, Percent_Identity=29.5336787564767, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=267, Percent_Identity=31.4606741573034, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=32.2709163346614, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17536985, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540714, Length=185, Percent_Identity=30.2702702702703, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=26.4822134387352, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=256, Percent_Identity=24.21875, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=184, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=262, Percent_Identity=27.0992366412214, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=271, Percent_Identity=25.830258302583, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=271, Percent_Identity=25.830258302583, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=33.7349397590361, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=33.7349397590361, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653139, Length=270, Percent_Identity=30.3703703703704, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920382, Length=263, Percent_Identity=27.7566539923954, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654903, Length=186, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922422, Length=259, Percent_Identity=24.7104247104247, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29480; Mature: 29480

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLVETVEPRGVVRLTLNRPEVRNAFDDRLIAELTEAVLRHGRDPAVRVIVLAAQGRAF
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
SAGADLGWMRRMADFSRSENLIDALELARMLQVIDLCPKPTVALVQGVAYGGGVGLVAAC
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
DIALAAEPALFCLSEVRLGLIPAVISPYVIRAIGPRACRRLFLTAETFGAQRALGLGLVS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVVAADALEGVAAAVIAALLAGAPEAQSEVKDLIRLVENSVMDEALLRESAVRIADRRSS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEAREGMAAFLEKRSPVWMTPDPEGEEARACFHDC
HHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCC
>Mature Secondary Structure
MDLLVETVEPRGVVRLTLNRPEVRNAFDDRLIAELTEAVLRHGRDPAVRVIVLAAQGRAF
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
SAGADLGWMRRMADFSRSENLIDALELARMLQVIDLCPKPTVALVQGVAYGGGVGLVAAC
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
DIALAAEPALFCLSEVRLGLIPAVISPYVIRAIGPRACRRLFLTAETFGAQRALGLGLVS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVVAADALEGVAAAVIAALLAGAPEAQSEVKDLIRLVENSVMDEALLRESAVRIADRRSS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEAREGMAAFLEKRSPVWMTPDPEGEEARACFHDC
HHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA