Click here to switch to the map view.

The map label for this gene is trpC

Identifier: 83593232

GI number: 83593232

Start: 2198767

End: 2199558

Strand: Direct

Name: trpC

Synonym: Rru_A1897

Alternate gene names: 83593232

Gene position: 2198767-2199558 (Clockwise)

Preceding gene: 83593231

Following gene: 83593233

Centisome position: 50.51

GC content: 69.19

Gene sequence:

>792_bases
GTGAGCGACATTCTGCGCGAGATCTGCGACACCACCCGCGCCGAGGTGGCGCGGCGCAAGGCCGCCCTGCCCTTAGCCGA
TGTGACGGCGCGGGCGGAAGACGCCAACGCGCCGCGCGGCTTCGCCAACGCCCTGACCCGCACCGCCGACAGCGGTCGGC
CGGCGTTGATCGCCGAAATCAAAAAGGCCTCGCCCTCGGCCGGGTTGATCCGCCCCGATTTCAACCCCGCCGTCCTGGCA
CGCGCCTATCACGCCGCCGGGGCGACCTGCCTGTCGGTGCTGACCGATGGACCCTATTTCCAAGGGCACGCCGATTTCCT
GATCGCCGCCCGCGCCGCCGTTCCCCTGCCGGTGCTGCGCAAGGATTTCATGGTCGATCCCTGGCAGGTGGTCGAGGCCC
GGGCGATGGGGGCCGATTGCATCCTGGTCATCCTGGCCGCCCTTGACGACGGCGCCGCCGCCGAGATCGAAGCCTGCGCC
CATGACTGGGGCATGGACGTGCTGGCCGAGGTCCATAACGAAGAGGAATGCGCCCGCGCCCTGACCTGCCTGACCACGCC
GCTGCTCGGCGTCAACAACCGTAATCTGAAAACCCTGGTCACCGATCTGGCGGTGACCGAGCGTCTGGCCAAGATGGTGC
CCGCCGACCGGGTGCTGGTCGCCGAAAGCGGTCTGCGCACCCGCAAGGACCTCGACCGCATGACCGCCGTCGGCGCCCGC
CGCTTCCTGATCGGCGAACATTTCATGCGCCAACCCGATGTCGGCGACGCCGTGCGCGCCCTGATCGGCTGA

Upstream 100 bases:

>100_bases
ATCTGGCGACCGGGGCGGCGCGGGCCGCCCAGGCCATCGACAGCGGCGCGGCGAAGGACACCCTGGCGCGCATGATCGCC
ATCATCGGAGCCCCGGCATC

Downstream 100 bases:

>100_bases
TCCCGGAAAGGGCGCGGCCCGGGAAGGCCGCCCCCCTCCTCTCCCCCCGTGTCTCTTTGCCGCCACACCCCCTGCGCCAC
CGACAAACCGTCCAGGGGTT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEIKKASPSAGLIRPDFNPAVLA
RAYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLRKDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACA
HDWGMDVLAEVHNEEECARALTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGAR
RFLIGEHFMRQPDVGDAVRALIG

Sequences:

>Translated_263_residues
MSDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEIKKASPSAGLIRPDFNPAVLA
RAYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLRKDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACA
HDWGMDVLAEVHNEEECARALTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGAR
RFLIGEHFMRQPDVGDAVRALIG
>Mature_262_residues
SDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEIKKASPSAGLIRPDFNPAVLAR
AYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLRKDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACAH
DWGMDVLAEVHNEEECARALTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGARR
FLIGEHFMRQPDVGDAVRALIG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=262, Percent_Identity=39.3129770992366, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=222, Percent_Identity=35.5855855855856, Blast_Score=132, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_RHORT (Q2RT48)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426984.1
- HSSP:   Q56319
- ProteinModelPortal:   Q2RT48
- SMR:   Q2RT48
- STRING:   Q2RT48
- GeneID:   3835321
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1897
- NMPDR:   fig|1085.1.peg.2470
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- PhylomeDB:   Q2RT48
- BioCyc:   RRUB269796:RRU_A1897-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28201; Mature: 28070

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
KKASPSAGLIRPDFNPAVLARAYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHH
KDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACAHDWGMDVLAEVHNEEECARA
HHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
RFLIGEHFMRQPDVGDAVRALIG
HHHHHHHHHCCCCHHHHHHHHHC
>Mature Secondary Structure 
SDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
KKASPSAGLIRPDFNPAVLARAYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHH
KDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACAHDWGMDVLAEVHNEEECARA
HHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
RFLIGEHFMRQPDVGDAVRALIG
HHHHHHHHHCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA