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The map label for this gene is rsh [H]

Identifier: 83593191

GI number: 83593191

Start: 2153978

End: 2156125

Strand: Reverse

Name: rsh [H]

Synonym: Rru_A1856

Alternate gene names: 83593191

Gene position: 2156125-2153978 (Counterclockwise)

Preceding gene: 83593192

Following gene: 83593190

Centisome position: 49.53

GC content: 61.64

Gene sequence:

>2148_bases
ATGGCCATGATGCGCCAGTTCGAACTGGTCGAGCGGGTCAAGGCCTATGACCCCAACGCCAACGAGGATCTGCTCAACCG
CGCCTACGTCTACGCGATGAAGATGCATGGCTCGCAATTGCGGGCCTCGGGCGATCCCTATTTTTCCCATCCCATTGATG
TCGCCGGGATCCTGACCCGCTATAAGCTCGACTGCGCCTCGATCATCACGGCGCTGTTGCACGACACCATCGAGGACACC
GAGGCGACGCTGGAGGATGTCCGCCAGCTTTTCGGCAATGATGTCGCCCGTCTCGTCGATGGGGTGACCAAGCTCACCCG
TATCCAGATCTCCTCCGACCACGCCAAGCAGGCCGAGAATTTCCGCAAGCTGCTGCTGGCGATGAGCGAGGACATCCGCG
TCCTGATGGTCAAGCTGGCCGACCGCCTGCACAACATGCGGACGCTGCATTTCATCCGCAAGCCGGAGAAGCGCGCCCGC
ATCGCCCTTGAGACCATGGAGATCTACGCGCCGCTCGCCGAACGCATCGGCATGGCCGAGATCAAGGAGGAACTCGAGGA
TCTGGCCTTCCGCGAGCTCTATCCCGACGCCAAGGAAGGCATCGAGGCGCGGCTGACCTTTCTGCGCGAGCAGGGCGGCA
CCCTGGTGCCCAAGGTCATCGATCAGCTCAAGGCCGCTTTGGCCGAGCACGGACTGACCGCCGAGATCACCGGGCGCGAA
AAGACGCCCTATTCGATCTGGCAGAAGATGAAGCGCAAGAACATCTCGTTCGAGCAGCTGTCCGACATCATGGCCTTCCG
CATCACCGTTGAAAACCTTGAGCAATGCTATCAGGCGCTGGGCATCATCCACGCCTCCTATCCGATGATCCCCGACCGCT
TCAAGGACTATATCTCGACGCCCAAGCGCAACGGCTATCAGTCGATCCATACGGCGGTCATCGGGCCCGAACGCCTGCGC
ATCGAAATCCAGATCCGCACCGCCGAGATGCATTCGGTGGCCGAACTCGGCGTGGCCGCCCATTGGTCCTATAAGCAGGG
CTCGCCGGTCATGGATGGCCGGCAATATCGCTGGATCCGCGAGTTGCTCGAAATTCTCGAGCATACCTCCAGTCCCGAGG
AATTCCTTGAGCATACCAAGCTCGAGATGTTCAGCGATCAGGTGTTCTGCTTCACCCCCAAGGGTGATCTGATCGGCCTG
CCGAGCGGGGCGACGCCGGTCGATTTCGCCTATGCGGTCCATACCCAGGTCGGCGACCGCTGCGTCTCGGCCAAGGTCAA
TGGCCGGCTGGTGCCCCTGCGCACGCCCCTGCACAACGGCGATCAGGTGGAGATCGCCACCTCGAAGGCGCAGACGCCCT
CGCCCGAATGGGAACGCTTCGTCGTTACCGGCAAGGCGCGGGCCCAGATCCGCAAATTCGTGCGCTCGCAGCGCCGCGAC
CAATATCTGATCCTCGGGCGCCAGTTGCTCGAACGGGCCTTCAAGGCCGAAAACTACGAGATGACGGAAAAGGGCCTCGA
CGGAGTCCTCAAGAAATTCCGCGCCGATAGCGTCGAAGATCTGATCGTCGATGTCGGCGAGGGCCAGTTGCCGGCCCGCG
AGGTCGTGCAGGCGGTCTATCCCGGCCTCAAGATGGTTCCCAAGCTGGCCGCCGTCGTCACCCTGGGGCGGACCAAGAAG
CCGCGGGCCAGCGACGACCACAGCTTCAAGATCAAGGGGATGATCCCCGGCATGGCGTTACATTTCGCCAAATGCTGTCA
CTCGCTGCCCGGGGACCGCATCGTCGGCATCGTCACCACCGGCAAGGGCATCACCATTCACACCATCGATTGCGACCAGC
TCGAGCAGTTTTCCGACGAGCCCGAGCGCTGGCTTGATCTGGCCTGGGATGCCGAGGCCGATAGCCAGGTTCACGTCGGC
CGGGTCAATGTGGTGGTCGCCAATGAACCGGGCAGTCTTGGCGCCCTGACCACGGTGATTGCCAAGAACCTGGGGAATAT
CACCAATCTCAAGATCACCAATCGGCAGCAGGATTTCTTCGACATGATCGTCGATGTCGAGGTCAAGGATGTCCGTCACC
TGACCAACATCATCGCCGCCCTGCGCGCCACATCCGCCATCAATTACGTCGAGCGCGCGAGGCACTAA

Upstream 100 bases:

>100_bases
ACGCCATCGGTTCCGTTTCCCTTCGTCCCCCCTTCGCCCGATCCCTGTTCGTTCTCGCGGGGCCCTGCGCACCCATCGGG
CCGGGAGCGGGGCGGAGGAC

Downstream 100 bases:

>100_bases
GGCCATGCTGTTCAACAGGCGCGTCAAGCCCTCCCTCGGCGCCCGGATCAAGGCGTTCTTCCTGCCCCGCACCGGCTGGA
AGCGGTCGGCGCGCTATATC

Product: (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MAMMRQFELVERVKAYDPNANEDLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTRYKLDCASIITALLHDTIEDT
EATLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAENFRKLLLAMSEDIRVLMVKLADRLHNMRTLHFIRKPEKRAR
IALETMEIYAPLAERIGMAEIKEELEDLAFRELYPDAKEGIEARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGRE
KTPYSIWQKMKRKNISFEQLSDIMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYISTPKRNGYQSIHTAVIGPERLR
IEIQIRTAEMHSVAELGVAAHWSYKQGSPVMDGRQYRWIRELLEILEHTSSPEEFLEHTKLEMFSDQVFCFTPKGDLIGL
PSGATPVDFAYAVHTQVGDRCVSAKVNGRLVPLRTPLHNGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRD
QYLILGRQLLERAFKAENYEMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVYPGLKMVPKLAAVVTLGRTKK
PRASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTTGKGITIHTIDCDQLEQFSDEPERWLDLAWDAEADSQVHVG
RVNVVVANEPGSLGALTTVIAKNLGNITNLKITNRQQDFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH

Sequences:

>Translated_715_residues
MAMMRQFELVERVKAYDPNANEDLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTRYKLDCASIITALLHDTIEDT
EATLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAENFRKLLLAMSEDIRVLMVKLADRLHNMRTLHFIRKPEKRAR
IALETMEIYAPLAERIGMAEIKEELEDLAFRELYPDAKEGIEARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGRE
KTPYSIWQKMKRKNISFEQLSDIMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYISTPKRNGYQSIHTAVIGPERLR
IEIQIRTAEMHSVAELGVAAHWSYKQGSPVMDGRQYRWIRELLEILEHTSSPEEFLEHTKLEMFSDQVFCFTPKGDLIGL
PSGATPVDFAYAVHTQVGDRCVSAKVNGRLVPLRTPLHNGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRD
QYLILGRQLLERAFKAENYEMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVYPGLKMVPKLAAVVTLGRTKK
PRASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTTGKGITIHTIDCDQLEQFSDEPERWLDLAWDAEADSQVHVG
RVNVVVANEPGSLGALTTVIAKNLGNITNLKITNRQQDFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH
>Mature_714_residues
AMMRQFELVERVKAYDPNANEDLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTRYKLDCASIITALLHDTIEDTE
ATLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAENFRKLLLAMSEDIRVLMVKLADRLHNMRTLHFIRKPEKRARI
ALETMEIYAPLAERIGMAEIKEELEDLAFRELYPDAKEGIEARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGREK
TPYSIWQKMKRKNISFEQLSDIMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYISTPKRNGYQSIHTAVIGPERLRI
EIQIRTAEMHSVAELGVAAHWSYKQGSPVMDGRQYRWIRELLEILEHTSSPEEFLEHTKLEMFSDQVFCFTPKGDLIGLP
SGATPVDFAYAVHTQVGDRCVSAKVNGRLVPLRTPLHNGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRDQ
YLILGRQLLERAFKAENYEMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVYPGLKMVPKLAAVVTLGRTKKP
RASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTTGKGITIHTIDCDQLEQFSDEPERWLDLAWDAEADSQVHVGR
VNVVVANEPGSLGALTTVIAKNLGNITNLKITNRQQDFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=130, Percent_Identity=39.2307692307692, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790082, Length=719, Percent_Identity=40.3337969401947, Blast_Score=543, Evalue=1e-155,
Organism=Escherichia coli, GI1789147, Length=663, Percent_Identity=36.0482654600302, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=33.8345864661654, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=37.9032258064516, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 80773; Mature: 80642

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMMRQFELVERVKAYDPNANEDLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTR
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCHHCCCCCCCCCCCCHHHHHHHH
YKLDCASIITALLHDTIEDTEATLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCHHHHHHHH
FRKLLLAMSEDIRVLMVKLADRLHNMRTLHFIRKPEKRARIALETMEIYAPLAERIGMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHH
IKEELEDLAFRELYPDAKEGIEARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGRE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCEEEECCCC
KTPYSIWQKMKRKNISFEQLSDIMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYIST
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
PKRNGYQSIHTAVIGPERLRIEIQIRTAEMHSVAELGVAAHWSYKQGSPVMDGRQYRWIR
CCCCCHHHHHHHEECCCEEEEEEEEEEHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHH
ELLEILEHTSSPEEFLEHTKLEMFSDQVFCFTPKGDLIGLPSGATPVDFAYAVHTQVGDR
HHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCH
CVSAKVNGRLVPLRTPLHNGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRD
HEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCC
QYLILGRQLLERAFKAENYEMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHC
PGLKMVPKLAAVVTLGRTKKPRASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEE
GKGITIHTIDCDQLEQFSDEPERWLDLAWDAEADSQVHVGRVNVVVANEPGSLGALTTVI
CCCEEEEEECHHHHHHHCCCHHHHHEEEECCCCCCCEEEEEEEEEEECCCCCHHHHHHHH
AKNLGNITNLKITNRQQDFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH
HHHCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AMMRQFELVERVKAYDPNANEDLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTR
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCHHCCCCCCCCCCCCHHHHHHHH
YKLDCASIITALLHDTIEDTEATLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCHHHHHHHH
FRKLLLAMSEDIRVLMVKLADRLHNMRTLHFIRKPEKRARIALETMEIYAPLAERIGMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHH
IKEELEDLAFRELYPDAKEGIEARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGRE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCEEEECCCC
KTPYSIWQKMKRKNISFEQLSDIMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYIST
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
PKRNGYQSIHTAVIGPERLRIEIQIRTAEMHSVAELGVAAHWSYKQGSPVMDGRQYRWIR
CCCCCHHHHHHHEECCCEEEEEEEEEEHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHH
ELLEILEHTSSPEEFLEHTKLEMFSDQVFCFTPKGDLIGLPSGATPVDFAYAVHTQVGDR
HHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCH
CVSAKVNGRLVPLRTPLHNGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRD
HEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCC
QYLILGRQLLERAFKAENYEMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHC
PGLKMVPKLAAVVTLGRTKKPRASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEE
GKGITIHTIDCDQLEQFSDEPERWLDLAWDAEADSQVHVGRVNVVVANEPGSLGALTTVI
CCCEEEEEECHHHHHHHCCCHHHHHEEEECCCCCCCEEEEEEEEEEECCCCCHHHHHHHH
AKNLGNITNLKITNRQQDFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH
HHHCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA