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The map label for this gene is rnc [H]

Identifier: 83593187

GI number: 83593187

Start: 2150932

End: 2151597

Strand: Reverse

Name: rnc [H]

Synonym: Rru_A1852

Alternate gene names: 83593187

Gene position: 2151597-2150932 (Counterclockwise)

Preceding gene: 83593188

Following gene: 83593186

Centisome position: 49.43

GC content: 68.47

Gene sequence:

>666_bases
ATGGCCCGCGACCTGAACGCTCTTCAGATCGCCCTGGATCATCGGTTCACCGACCCCGCCTTGTTGGCGCGCGCCCTGAC
CCACCGTTCGCGCGAGGGCAGGCCGAGCTACGAGCGCCTGGAGTTTCTGGGCGACCGGGTGTTGGGGCTGGTGGTCGCCG
AGATGCTGTACGCCCGCTTCCCGACCGAGGACGAGGGCGCCTTGGCGCGCCGTCACGCCAGTCTGGTTCGCCAAGACACG
GTGGCCCGTGTCGCCCAGAGCGTTGGCCTGGGCGAGTTGATGGAGCTGTCGCGGGGCGAAGAGGAATTGGGCGGGCAGTT
CAATCCCTCGCTGCTCTGCGATGTCTGCGAAGCGGTGCTGGGCGCGCTCCATCTCGATGGCGGCTACGCCAAGGCCCAGC
GCTTCGTCGAAGCGCGCTGGGCGCCCTTGATGGCCGAAGACCTGACCCCGCCCAAGGACGCCAAGACGGCCTTGCAGGAA
TGGGCCCAGGGACGGGGCCTGCCGCTGCCCACCTATGCGGTGGAAGGGCGGGACGGTCCGCCCCACAAGCCGATGTTCAC
GGTGAGCGTGACGGTCAAGGATAACGGCTCGGAAAGCGCCCTGGGGGCCTCCAAGCGGCTGGCCGAACAGGCCGCCGCCC
AAAGGCTTCTTGATCGTCTGGCCTGA

Upstream 100 bases:

>100_bases
CGATTAAGGACGCCTGCGTGGTGGGATGGTTTGTTTTGTTGACGGGACGGCGTAAGGCCTGTCCCGTCTTTTGTCGGTTT
TTCCGGGTTTTGGAGGGTCC

Downstream 100 bases:

>100_bases
TCAGGACCGACAGGGGTGTGAAAGCCGCGTTCGATGATCCCCATTGGACGCGGTTTGATTTAGATTGAACGGGAGACCGA
GCGGTGATCGGCCCGCGGTC

Product: RNAse III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MARDLNALQIALDHRFTDPALLARALTHRSREGRPSYERLEFLGDRVLGLVVAEMLYARFPTEDEGALARRHASLVRQDT
VARVAQSVGLGELMELSRGEEELGGQFNPSLLCDVCEAVLGALHLDGGYAKAQRFVEARWAPLMAEDLTPPKDAKTALQE
WAQGRGLPLPTYAVEGRDGPPHKPMFTVSVTVKDNGSESALGASKRLAEQAAAQRLLDRLA

Sequences:

>Translated_221_residues
MARDLNALQIALDHRFTDPALLARALTHRSREGRPSYERLEFLGDRVLGLVVAEMLYARFPTEDEGALARRHASLVRQDT
VARVAQSVGLGELMELSRGEEELGGQFNPSLLCDVCEAVLGALHLDGGYAKAQRFVEARWAPLMAEDLTPPKDAKTALQE
WAQGRGLPLPTYAVEGRDGPPHKPMFTVSVTVKDNGSESALGASKRLAEQAAAQRLLDRLA
>Mature_220_residues
ARDLNALQIALDHRFTDPALLARALTHRSREGRPSYERLEFLGDRVLGLVVAEMLYARFPTEDEGALARRHASLVRQDTV
ARVAQSVGLGELMELSRGEEELGGQFNPSLLCDVCEAVLGALHLDGGYAKAQRFVEARWAPLMAEDLTPPKDAKTALQEW
AQGRGLPLPTYAVEGRDGPPHKPMFTVSVTVKDNGSESALGASKRLAEQAAAQRLLDRLA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=28.5087719298246, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=28.5087719298246, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788920, Length=191, Percent_Identity=41.8848167539267, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=30.7359307359307, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=30.7359307359307, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=30.7017543859649, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 24138; Mature: 24007

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARDLNALQIALDHRFTDPALLARALTHRSREGRPSYERLEFLGDRVLGLVVAEMLYARF
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PTEDEGALARRHASLVRQDTVARVAQSVGLGELMELSRGEEELGGQFNPSLLCDVCEAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
GALHLDGGYAKAQRFVEARWAPLMAEDLTPPKDAKTALQEWAQGRGLPLPTYAVEGRDGP
HHHHCCCCHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCC
PHKPMFTVSVTVKDNGSESALGASKRLAEQAAAQRLLDRLA
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ARDLNALQIALDHRFTDPALLARALTHRSREGRPSYERLEFLGDRVLGLVVAEMLYARF
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PTEDEGALARRHASLVRQDTVARVAQSVGLGELMELSRGEEELGGQFNPSLLCDVCEAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
GALHLDGGYAKAQRFVEARWAPLMAEDLTPPKDAKTALQEWAQGRGLPLPTYAVEGRDGP
HHHHCCCCHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCC
PHKPMFTVSVTVKDNGSESALGASKRLAEQAAAQRLLDRLA
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA