Click here to switch to the map view.

The map label for this gene is ecaA [H]

Identifier: 83593060

GI number: 83593060

Start: 2017887

End: 2018666

Strand: Reverse

Name: ecaA [H]

Synonym: Rru_A1725

Alternate gene names: 83593060

Gene position: 2018666-2017887 (Counterclockwise)

Preceding gene: 83593061

Following gene: 83593058

Centisome position: 46.38

GC content: 64.36

Gene sequence:

>780_bases
ATGGTCATGCAGCGCGCTTTTTCCCACGCCGCGATGGCGGTCGCTTTTGGTCTTGTCGGTTTTTCAGGGGCTCCGGCCGT
CGCCGCGGAGACCGCCCATCCGCCCCATTGGGCCTATGAAGGCAAGGGCGGCCCGGTTGACTGGGGCGCCCTGAGCGAGG
ACTACCATGCCTGCGCCGCCGGCAAGGAACAATCTCCGGTCGATATCCGCGATGCCATTCCGGCCAAGCTGCCGGCGATC
GCTCCGGCCTATCAGGCGCAGTCGGCCGTTGTCGTCAATAATGGCCATACGCTGCAGGTCAACGTATCCCCCGGGTCGTC
CCTGGACTTCCGGGGCCAGCGCTATGAGCTGCTGCAATACCACTTCCATCACCCCAGCGAACATTTGGTGAACGGCAAGG
CGGCGCCTTTGGAACTGCATCTGGTTCACAAGGGGCCGACCGCCCTGACGGTGATCGGCGTCATGCTGGTGCCCGGGGCG
GCCAATCCGGCGATCGAGGCGATCTGGAAGGTGGCGCCGGCCAAGGAAGGCGGCGAGGCGACGCTGGGGGATCCCGGCCC
CGACCTGGGCAAGCTTTTGCCCGAAAGCAAATCCTACACCTTCTATGAAGGCTCGCTGACGACGCCGCCCTGCTCGGAAG
TCGTCAATTGGATCAATCTGAAGACGCCGGTCACCGTGTCGGAGGATCAGATCGCCCGCTTTGCCGCCCTGTTCCCGATG
AACGCCCGGCCGCCCCAGGCCCTTCATCGCCGGATCATTCTCGAGAGCCAGGACCAATAA

Upstream 100 bases:

>100_bases
GCAAAAGGCGCGGACGCATTGTCCTTTTGGTTGGATCTGATAGGATGTAGTCTTCCGGTTGTGGGCTGATCGCAGCCCTA
TCCAATCGACGGAGGACTTA

Downstream 100 bases:

>100_bases
CCAGAGAGGCGGACGGGCCTCCAGACGAGACGGCGGCCCTAAGCCAGCAGGGACAACAAGGCCCGGGCGGACTCCTCCGA
CGAGGCGGGGTTCTGCCCGG

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MVMQRAFSHAAMAVAFGLVGFSGAPAVAAETAHPPHWAYEGKGGPVDWGALSEDYHACAAGKEQSPVDIRDAIPAKLPAI
APAYQAQSAVVVNNGHTLQVNVSPGSSLDFRGQRYELLQYHFHHPSEHLVNGKAAPLELHLVHKGPTALTVIGVMLVPGA
ANPAIEAIWKVAPAKEGGEATLGDPGPDLGKLLPESKSYTFYEGSLTTPPCSEVVNWINLKTPVTVSEDQIARFAALFPM
NARPPQALHRRIILESQDQ

Sequences:

>Translated_259_residues
MVMQRAFSHAAMAVAFGLVGFSGAPAVAAETAHPPHWAYEGKGGPVDWGALSEDYHACAAGKEQSPVDIRDAIPAKLPAI
APAYQAQSAVVVNNGHTLQVNVSPGSSLDFRGQRYELLQYHFHHPSEHLVNGKAAPLELHLVHKGPTALTVIGVMLVPGA
ANPAIEAIWKVAPAKEGGEATLGDPGPDLGKLLPESKSYTFYEGSLTTPPCSEVVNWINLKTPVTVSEDQIARFAALFPM
NARPPQALHRRIILESQDQ
>Mature_259_residues
MVMQRAFSHAAMAVAFGLVGFSGAPAVAAETAHPPHWAYEGKGGPVDWGALSEDYHACAAGKEQSPVDIRDAIPAKLPAI
APAYQAQSAVVVNNGHTLQVNVSPGSSLDFRGQRYELLQYHFHHPSEHLVNGKAAPLELHLVHKGPTALTVIGVMLVPGA
ANPAIEAIWKVAPAKEGGEATLGDPGPDLGKLLPESKSYTFYEGSLTTPPCSEVVNWINLKTPVTVSEDQIARFAALFPM
NARPPQALHRRIILESQDQ

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=259, Percent_Identity=34.7490347490347, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4885101, Length=266, Percent_Identity=34.2105263157895, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI258679498, Length=263, Percent_Identity=32.6996197718631, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI192447434, Length=263, Percent_Identity=32.6996197718631, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI192447432, Length=263, Percent_Identity=32.6996197718631, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI192447430, Length=263, Percent_Identity=32.6996197718631, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502517, Length=263, Percent_Identity=32.6996197718631, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI38348436, Length=260, Percent_Identity=32.6923076923077, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4885099, Length=264, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI62240989, Length=211, Percent_Identity=36.0189573459716, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI4502515, Length=224, Percent_Identity=30.3571428571429, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI45935383, Length=224, Percent_Identity=30.3571428571429, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI22027500, Length=255, Percent_Identity=30.9803921568627, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI169636420, Length=256, Percent_Identity=34.375, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502521, Length=235, Percent_Identity=33.1914893617021, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI6005723, Length=245, Percent_Identity=31.0204081632653, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194097398, Length=273, Percent_Identity=27.8388278388278, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI130979954, Length=270, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI130979679, Length=270, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI9910366, Length=270, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI6912284, Length=261, Percent_Identity=29.5019157088123, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17568715, Length=252, Percent_Identity=33.7301587301587, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32564019, Length=241, Percent_Identity=26.5560165975104, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737413, Length=269, Percent_Identity=32.3420074349442, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645604, Length=278, Percent_Identity=27.3381294964029, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161079350, Length=240, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650523, Length=228, Percent_Identity=31.140350877193, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27596; Mature: 27596

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMQRAFSHAAMAVAFGLVGFSGAPAVAAETAHPPHWAYEGKGGPVDWGALSEDYHACAA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCCCCHHHHHC
GKEQSPVDIRDAIPAKLPAIAPAYQAQSAVVVNNGHTLQVNVSPGSSLDFRGQRYELLQY
CCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCEEEHHH
HFHHPSEHLVNGKAAPLELHLVHKGPTALTVIGVMLVPGAANPAIEAIWKVAPAKEGGEA
HCCCCHHHHCCCCCCCEEEEEEECCCHHHHEEEHHHCCCCCCHHHHHHHHHCCCCCCCCC
TLGDPGPDLGKLLPESKSYTFYEGSLTTPPCSEVVNWINLKTPVTVSEDQIARFAALFPM
CCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHCCC
NARPPQALHRRIILESQDQ
CCCCHHHHHHEEEECCCCC
>Mature Secondary Structure
MVMQRAFSHAAMAVAFGLVGFSGAPAVAAETAHPPHWAYEGKGGPVDWGALSEDYHACAA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCCCCHHHHHC
GKEQSPVDIRDAIPAKLPAIAPAYQAQSAVVVNNGHTLQVNVSPGSSLDFRGQRYELLQY
CCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCEEEHHH
HFHHPSEHLVNGKAAPLELHLVHKGPTALTVIGVMLVPGAANPAIEAIWKVAPAKEGGEA
HCCCCHHHHCCCCCCCEEEEEEECCCHHHHEEEHHHCCCCCCHHHHHHHHHCCCCCCCCC
TLGDPGPDLGKLLPESKSYTFYEGSLTTPPCSEVVNWINLKTPVTVSEDQIARFAALFPM
CCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHCCC
NARPPQALHRRIILESQDQ
CCCCHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006032; 11759840 [H]