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The map label for this gene is mazG [H]

Identifier: 83593025

GI number: 83593025

Start: 1981368

End: 1982207

Strand: Reverse

Name: mazG [H]

Synonym: Rru_A1690

Alternate gene names: 83593025

Gene position: 1982207-1981368 (Counterclockwise)

Preceding gene: 83593026

Following gene: 83593024

Centisome position: 45.54

GC content: 67.26

Gene sequence:

>840_bases
GTGACCTCGCCTTCGCCGCCGCCCCCGTCGCCGATCGATCGCTTGCTCGCCCTGATGGCCCGGCTGCGCGACCCCTTGCG
CGGATGCCCCTGGGACCGTGCCCAGACCTTCGCCAGCCTCGCCCCCCATACCCTGGAAGAGGCCTATGAGGTGGTTGACG
CCATCGAACGCGGGGCGAGGAGCGATCTGCGCGACGAATTGGGCGATCTGCTGCTGCAGGTCGTTTTCCATGCCCGCTTG
GCCGAGGAAGAGGGCGCCTTCGATTTCGACGCCGTCGCCACTGCCATCGCCGACAAGCTCGAACACCGCCATCCCCATAT
CTTTGGAGAAAGCAGCCTTTCGCCCCCCACCGACGCCGCCGCCCAGACCACCGCCTGGGAGGAGGGCAAGGCCCGCGACC
GTCAGGCCCAGGCCGCCGCCGAGGGGCGGGTCGCCAGCGTGCTCGATGGCGTGACCGCCACCCTGCCCGCCCTGGCCCGC
GCCCATAAGCTGGGGAACCGGGTCGCCCGCGTCGGTTTTGACTGGCCCGATATCGGCGCCGTGGTGGAAAAGCTCCACGA
GGAATTGGGGGAACTTCAGGAAGAATTGGCGGGCCGCGATCAGGAGCGTATCATCGAGGAAATGGGCGATCTTTTGTTCG
TGGTCGTCCAGCTTGCCCGCAGTCTCGACGTCGATTCCGAAACGGCGCTGCGACGGGCGAACGCCAAATTCGATCGGCGC
TTTCGCCATGTGGAATCCCGTCTGGCGGAAAGCGGTCGCGGCCCGGCGGACTCGACCCTGGAGGAAATGGAAGAGCTATG
GCGCGACGCCAAACGCCGGGAACGCGGGGAACCGACCTGA

Upstream 100 bases:

>100_bases
TGCCGGCGCCTTCGCCCTGCCCCCCCATATCCGCGCCGCCGCCCGAGGCTGAGCGCGCCCGCTGAAAAAACCGCCGCCGC
TCTACAAGGAGATCTCGCCC

Downstream 100 bases:

>100_bases
CGGCCCCCTCCCCCGATTCGCGTCCCCGCTGGGCGGCGCAAACTTTTGATCGCCGCCTAAAAGCGGCGATCATCACGGTC
GCGGCTTGCCTGCTGCTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTSPSPPPPSPIDRLLALMARLRDPLRGCPWDRAQTFASLAPHTLEEAYEVVDAIERGARSDLRDELGDLLLQVVFHARL
AEEEGAFDFDAVATAIADKLEHRHPHIFGESSLSPPTDAAAQTTAWEEGKARDRQAQAAAEGRVASVLDGVTATLPALAR
AHKLGNRVARVGFDWPDIGAVVEKLHEELGELQEELAGRDQERIIEEMGDLLFVVVQLARSLDVDSETALRRANAKFDRR
FRHVESRLAESGRGPADSTLEEMEELWRDAKRRERGEPT

Sequences:

>Translated_279_residues
MTSPSPPPPSPIDRLLALMARLRDPLRGCPWDRAQTFASLAPHTLEEAYEVVDAIERGARSDLRDELGDLLLQVVFHARL
AEEEGAFDFDAVATAIADKLEHRHPHIFGESSLSPPTDAAAQTTAWEEGKARDRQAQAAAEGRVASVLDGVTATLPALAR
AHKLGNRVARVGFDWPDIGAVVEKLHEELGELQEELAGRDQERIIEEMGDLLFVVVQLARSLDVDSETALRRANAKFDRR
FRHVESRLAESGRGPADSTLEEMEELWRDAKRRERGEPT
>Mature_278_residues
TSPSPPPPSPIDRLLALMARLRDPLRGCPWDRAQTFASLAPHTLEEAYEVVDAIERGARSDLRDELGDLLLQVVFHARLA
EEEGAFDFDAVATAIADKLEHRHPHIFGESSLSPPTDAAAQTTAWEEGKARDRQAQAAAEGRVASVLDGVTATLPALARA
HKLGNRVARVGFDWPDIGAVVEKLHEELGELQEELAGRDQERIIEEMGDLLFVVVQLARSLDVDSETALRRANAKFDRRF
RHVESRLAESGRGPADSTLEEMEELWRDAKRRERGEPT

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=267, Percent_Identity=52.4344569288389, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30932; Mature: 30801

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPSPPPPSPIDRLLALMARLRDPLRGCPWDRAQTFASLAPHTLEEAYEVVDAIERGAR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SDLRDELGDLLLQVVFHARLAEEEGAFDFDAVATAIADKLEHRHPHIFGESSLSPPTDAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AQTTAWEEGKARDRQAQAAAEGRVASVLDGVTATLPALARAHKLGNRVARVGFDWPDIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVEKLHEELGELQEELAGRDQERIIEEMGDLLFVVVQLARSLDVDSETALRRANAKFDRR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FRHVESRLAESGRGPADSTLEEMEELWRDAKRRERGEPT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSPSPPPPSPIDRLLALMARLRDPLRGCPWDRAQTFASLAPHTLEEAYEVVDAIERGAR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SDLRDELGDLLLQVVFHARLAEEEGAFDFDAVATAIADKLEHRHPHIFGESSLSPPTDAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AQTTAWEEGKARDRQAQAAAEGRVASVLDGVTATLPALARAHKLGNRVARVGFDWPDIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVEKLHEELGELQEELAGRDQERIIEEMGDLLFVVVQLARSLDVDSETALRRANAKFDRR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FRHVESRLAESGRGPADSTLEEMEELWRDAKRRERGEPT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]