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The map label for this gene is lpxB [H]

Identifier: 83592934

GI number: 83592934

Start: 1883290

End: 1884513

Strand: Direct

Name: lpxB [H]

Synonym: Rru_A1599

Alternate gene names: 83592934

Gene position: 1883290-1884513 (Clockwise)

Preceding gene: 83592933

Following gene: 83592937

Centisome position: 43.27

GC content: 66.26

Gene sequence:

>1224_bases
ATGACCACGACAGACCAGGATCAGGGACCGCTGATCTATATCATCGCCGGCGAGCCCTCGGGGGATCAACTGGGCGCCCA
GATCATGCGCGGGCTCAAGATCGAGACCGCCGGCCGGGTCCGCTTCGCCGGCATCGGCGGTGAACAGATGGCCGAAGAGG
GGCTGAACAGTCTGGTTCCGCTGACGGAACTGGCGGTGATGGGCTTTTTGGAAGTCATCCCCAGCGCGCTGCGCATTCTG
CGGCGCCTTCGCCAGACCCTTGCCGATATCGCCCTCAAGCGCCCCGATGCGGTGGTGACCATCGATTCCTGGGGCTTTAC
CGGGCGCATTCATGCTGGCCTGAAAAAGGCCGGCAACCCGGCGGTGCGCCTCCATTATGTCGCGCCGATGGTCTGGGCCT
GGAACGCCGGCCGTGTGCATCATGTCGCCGCCCGGGTTGACCATCTGATGTGCCTGTGGCCATTCGAGCCGCCTTTGTTT
GAGGCCGCCGGTCTGGCCAGCAGCCATGTCGGTCATCCGGTGATCGAAACCCCGGCCGGGGCGGGCAATGGCCCGGCCTT
TCGCCAAGCCCATGATATCGCCGCCGAGGCCCCCCTGCTTGTCGTTCTGCCGGGCAGCCGGCGCGGCGAGGTGCGGCGCC
TGCTGCCGGTCTTCGCCGCCGCTGTCGAGAAACTGGCCGACCGCCACCCCGATCTGCGGGTGGTTATTCCGACCCTGACC
TATCTGCGCAGCTATTTGCTCGATGAAACCGCCTCCTGGCCGGTCGAGGTCAGCGTGGTCACCGGGCAAAGCGGCAAGTT
CGACGCCTTCGCCGCCGCCAACGCGGCGATCGCCGCCTCGGGAACCGTCAGCCTGGAACTGGCGATGGCCGGAACCCCCC
ATCTCATCGCCTATCGGGTGAACGGATTGACGGCCGAGATCGCCAAGCGGCTGGTGACGGTGCGCTTCGCCGATATGGTC
AACATCCTGTTGGACCGCCCGGCGATCCCCGAATTGCTCCAGACCGAATGCACCCCGGCCAAACTGGCCGAGACCGCCGA
AAGGCTGATGACCGACGAAACCACGCGCCGCGACCAGCGCGCCGCCATGGCCGAAGCGGTCAGTCAGCTGGGCGGACGGG
ATGATCCCCCCTCGCGCCGCGCCGCCCGCCTGATCTTGTCCAAGATCGCCCTAGAGCGGGATGGCGAAAAGTGTGCGCGG
TTTTCGCCTAAGATCCCGCTCTAA

Upstream 100 bases:

>100_bases
CCGGCGCGGTGGTGCTGCTTGATCCGGCGGGCCTGGGCAAGCGCGCCGATGACCTTGGCCTGTTCTTTGTGGGGCTGAGC
GCCGAAGGGGAGGTGCCGTC

Downstream 100 bases:

>100_bases
CATTTAGATTTAGATCAGGATTCAGATTTCAGGTCGATCAGACCTGAAATCTGAATCCTGATCTAAGGCGGTGAGCCGCC
GGAGAGCGGGACGATAAAAA

Product: Lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTTTDQDQGPLIYIIAGEPSGDQLGAQIMRGLKIETAGRVRFAGIGGEQMAEEGLNSLVPLTELAVMGFLEVIPSALRIL
RRLRQTLADIALKRPDAVVTIDSWGFTGRIHAGLKKAGNPAVRLHYVAPMVWAWNAGRVHHVAARVDHLMCLWPFEPPLF
EAAGLASSHVGHPVIETPAGAGNGPAFRQAHDIAAEAPLLVVLPGSRRGEVRRLLPVFAAAVEKLADRHPDLRVVIPTLT
YLRSYLLDETASWPVEVSVVTGQSGKFDAFAAANAAIAASGTVSLELAMAGTPHLIAYRVNGLTAEIAKRLVTVRFADMV
NILLDRPAIPELLQTECTPAKLAETAERLMTDETTRRDQRAAMAEAVSQLGGRDDPPSRRAARLILSKIALERDGEKCAR
FSPKIPL

Sequences:

>Translated_407_residues
MTTTDQDQGPLIYIIAGEPSGDQLGAQIMRGLKIETAGRVRFAGIGGEQMAEEGLNSLVPLTELAVMGFLEVIPSALRIL
RRLRQTLADIALKRPDAVVTIDSWGFTGRIHAGLKKAGNPAVRLHYVAPMVWAWNAGRVHHVAARVDHLMCLWPFEPPLF
EAAGLASSHVGHPVIETPAGAGNGPAFRQAHDIAAEAPLLVVLPGSRRGEVRRLLPVFAAAVEKLADRHPDLRVVIPTLT
YLRSYLLDETASWPVEVSVVTGQSGKFDAFAAANAAIAASGTVSLELAMAGTPHLIAYRVNGLTAEIAKRLVTVRFADMV
NILLDRPAIPELLQTECTPAKLAETAERLMTDETTRRDQRAAMAEAVSQLGGRDDPPSRRAARLILSKIALERDGEKCAR
FSPKIPL
>Mature_406_residues
TTTDQDQGPLIYIIAGEPSGDQLGAQIMRGLKIETAGRVRFAGIGGEQMAEEGLNSLVPLTELAVMGFLEVIPSALRILR
RLRQTLADIALKRPDAVVTIDSWGFTGRIHAGLKKAGNPAVRLHYVAPMVWAWNAGRVHHVAARVDHLMCLWPFEPPLFE
AAGLASSHVGHPVIETPAGAGNGPAFRQAHDIAAEAPLLVVLPGSRRGEVRRLLPVFAAAVEKLADRHPDLRVVIPTLTY
LRSYLLDETASWPVEVSVVTGQSGKFDAFAAANAAIAASGTVSLELAMAGTPHLIAYRVNGLTAEIAKRLVTVRFADMVN
ILLDRPAIPELLQTECTPAKLAETAERLMTDETTRRDQRAAMAEAVSQLGGRDDPPSRRAARLILSKIALERDGEKCARF
SPKIPL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=341, Percent_Identity=34.8973607038123, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43878; Mature: 43747

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTDQDQGPLIYIIAGEPSGDQLGAQIMRGLKIETAGRVRFAGIGGEQMAEEGLNSLVP
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEECCCCEEEECCCHHHHHHHHHHHCCC
LTELAVMGFLEVIPSALRILRRLRQTLADIALKRPDAVVTIDSWGFTGRIHAGLKKAGNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHCCCC
AVRLHYVAPMVWAWNAGRVHHVAARVDHLMCLWPFEPPLFEAAGLASSHVGHPVIETPAG
EEEEEEECCEEEECCCCCHHHHHHHHHHEEEEECCCCCHHHHHCCCHHCCCCCCEECCCC
AGNGPAFRQAHDIAAEAPLLVVLPGSRRGEVRRLLPVFAAAVEKLADRHPDLRVVIPTLT
CCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHH
YLRSYLLDETASWPVEVSVVTGQSGKFDAFAAANAAIAASGTVSLELAMAGTPHLIAYRV
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCCCEEEECCCEEEEEEECCCCEEEEEEE
NGLTAEIAKRLVTVRFADMVNILLDRPAIPELLQTECTPAKLAETAERLMTDETTRRDQR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
AAMAEAVSQLGGRDDPPSRRAARLILSKIALERDGEKCARFSPKIPL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TTTDQDQGPLIYIIAGEPSGDQLGAQIMRGLKIETAGRVRFAGIGGEQMAEEGLNSLVP
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEECCCCEEEECCCHHHHHHHHHHHCCC
LTELAVMGFLEVIPSALRILRRLRQTLADIALKRPDAVVTIDSWGFTGRIHAGLKKAGNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHCCCC
AVRLHYVAPMVWAWNAGRVHHVAARVDHLMCLWPFEPPLFEAAGLASSHVGHPVIETPAG
EEEEEEECCEEEECCCCCHHHHHHHHHHEEEEECCCCCHHHHHCCCHHCCCCCCEECCCC
AGNGPAFRQAHDIAAEAPLLVVLPGSRRGEVRRLLPVFAAAVEKLADRHPDLRVVIPTLT
CCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHH
YLRSYLLDETASWPVEVSVVTGQSGKFDAFAAANAAIAASGTVSLELAMAGTPHLIAYRV
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCCCEEEECCCEEEEEEECCCCEEEEEEE
NGLTAEIAKRLVTVRFADMVNILLDRPAIPELLQTECTPAKLAETAERLMTDETTRRDQR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
AAMAEAVSQLGGRDDPPSRRAARLILSKIALERDGEKCARFSPKIPL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA