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The map label for this gene is pyrH

Identifier: 83592923

GI number: 83592923

Start: 1872480

End: 1873232

Strand: Direct

Name: pyrH

Synonym: Rru_A1588

Alternate gene names: 83592923

Gene position: 1872480-1873232 (Clockwise)

Preceding gene: 83592922

Following gene: 83592924

Centisome position: 43.02

GC content: 63.88

Gene sequence:

>753_bases
ATGTCCGAGGATCAACCCCACGCCAATGGCGCCTACTACCGCCGGGTCCTGCTCAAGCTTTCCGGGGAGGGCCTGCTGGG
GAACAAGGAATTCGGTCTGGATCTGGAAATGGTCGACCGCGTGGCCGGCGAGGTCAAGGCCGCCCATGATCGCGGCATTC
AGGTTTGTCTGGTGATCGGCGGCGGCAATATCTTCCGCGGCATCTCGACCGCCGCCAAGGGCATGGACCGCACCAGCGCC
GATTACATGGGCATGCTGGCCACGGTGATGAACGCCCTGGCCGTGCAGAACGCCCTGGAAAAACGCGGCGTGCAAACCCG
CGTCCAGTCGGCGATCCCGATGTCGATGGTCTGCGAGCCCTATATCCGCCGCCGGGCGATCCGCCATATGGAAAAGGGCC
GGGTGGTGATTTTCGCCGCCGGCACCGGCAATCCCTTCTTCACCACCGATACCGCCGCCGCCCTGCGCGCCGTCGAGATG
AATTGCGACGCCATCCTCAAGGCGACCCAGGTCGATGGGGTCTATTCCGCCGATCCCAACAAGGTGCCCGACGCCGTGCG
CTTCGAGAGCCTGACCTTCACCGACGTGCTGACGCGCGATCTGCGGGTGATGGATACCTCGGCCATCGCCTTGGCGCGCG
ACAACAACATCCCTATAGTGGTGTTTTCCCTGCACACCCCTGGCGCTCTGGCCGATGTCCTTGATCGCCGGGGCCGTTTC
ACCGAGATCCTCTGCGACAGTCACCAGGAGTAA

Upstream 100 bases:

>100_bases
CCCGCCTGGGGTCTCGTAGCCGGGGCGCGGAGCTTAAAAATCACCAATCGACCAGGACGACATCGCCGGCCGACCGCGCG
GCGACAAGGGAGCTAACCGA

Downstream 100 bases:

>100_bases
GAACAGTGTCCGATGGCGCTTCCAGTTTCGACACCTTGAAAGCCGACCTCAGGCACCGCATGGATACGGCGGTCGAAGTC
TTGCGCAAGGATTTCGCGGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSEDQPHANGAYYRRVLLKLSGEGLLGNKEFGLDLEMVDRVAGEVKAAHDRGIQVCLVIGGGNIFRGISTAAKGMDRTSA
DYMGMLATVMNALAVQNALEKRGVQTRVQSAIPMSMVCEPYIRRRAIRHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEM
NCDAILKATQVDGVYSADPNKVPDAVRFESLTFTDVLTRDLRVMDTSAIALARDNNIPIVVFSLHTPGALADVLDRRGRF
TEILCDSHQE

Sequences:

>Translated_250_residues
MSEDQPHANGAYYRRVLLKLSGEGLLGNKEFGLDLEMVDRVAGEVKAAHDRGIQVCLVIGGGNIFRGISTAAKGMDRTSA
DYMGMLATVMNALAVQNALEKRGVQTRVQSAIPMSMVCEPYIRRRAIRHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEM
NCDAILKATQVDGVYSADPNKVPDAVRFESLTFTDVLTRDLRVMDTSAIALARDNNIPIVVFSLHTPGALADVLDRRGRF
TEILCDSHQE
>Mature_249_residues
SEDQPHANGAYYRRVLLKLSGEGLLGNKEFGLDLEMVDRVAGEVKAAHDRGIQVCLVIGGGNIFRGISTAAKGMDRTSAD
YMGMLATVMNALAVQNALEKRGVQTRVQSAIPMSMVCEPYIRRRAIRHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEMN
CDAILKATQVDGVYSADPNKVPDAVRFESLTFTDVLTRDLRVMDTSAIALARDNNIPIVVFSLHTPGALADVLDRRGRFT
EILCDSHQE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=222, Percent_Identity=53.6036036036036, Blast_Score=246, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_RHORT (Q2RU07)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426675.1
- HSSP:   P65938
- ProteinModelPortal:   Q2RU07
- SMR:   Q2RU07
- STRING:   Q2RU07
- GeneID:   3835005
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1588
- NMPDR:   fig|1085.1.peg.2779
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2RU07
- BioCyc:   RRUB269796:RRU_A1588-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27246; Mature: 27114

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: BINDING 61-61 BINDING 62-62 BINDING 66-66 BINDING 81-81 BINDING 169-169 BINDING 170-170 BINDING 175-175 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDQPHANGAYYRRVLLKLSGEGLLGNKEFGLDLEMVDRVAGEVKAAHDRGIQVCLVIG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEE
GGNIFRGISTAAKGMDRTSADYMGMLATVMNALAVQNALEKRGVQTRVQSAIPMSMVCEP
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHH
YIRRRAIRHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEMNCDAILKATQVDGVYSADPN
HHHHHHHHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHCCHHHHHHHHHCCCEECCCCC
KVPDAVRFESLTFTDVLTRDLRVMDTSAIALARDNNIPIVVFSLHTPGALADVLDRRGRF
CCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHCCCCE
TEILCDSHQE
EEHHCCCCCC
>Mature Secondary Structure 
SEDQPHANGAYYRRVLLKLSGEGLLGNKEFGLDLEMVDRVAGEVKAAHDRGIQVCLVIG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEE
GGNIFRGISTAAKGMDRTSADYMGMLATVMNALAVQNALEKRGVQTRVQSAIPMSMVCEP
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHH
YIRRRAIRHMEKGRVVIFAAGTGNPFFTTDTAAALRAVEMNCDAILKATQVDGVYSADPN
HHHHHHHHHHHCCCEEEEEECCCCCCEECHHHHHHHHHHCCHHHHHHHHHCCCEECCCCC
KVPDAVRFESLTFTDVLTRDLRVMDTSAIALARDNNIPIVVFSLHTPGALADVLDRRGRF
CCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHCCCCE
TEILCDSHQE
EEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA