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The map label for this gene is bioA [C]

Identifier: 83592876

GI number: 83592876

Start: 1814272

End: 1815615

Strand: Direct

Name: bioA [C]

Synonym: Rru_A1541

Alternate gene names: 83592876

Gene position: 1814272-1815615 (Clockwise)

Preceding gene: 83592871

Following gene: 83592877

Centisome position: 41.68

GC content: 64.36

Gene sequence:

>1344_bases
ATGAGCGATTTCGATCCGGCCCTGGCCGGTGGCCTGAGCCGCGCCGAGCTTGAGGCCCATTGGATGCCGTTTACCGCCAA
CCGCGAGTTCAAGGCCAATCCGCGCATGGTCGTTGGCGCCGAGGGGGTGCATTACATCGATGCCCGTGGCCGCAAGCTTT
ATGACAGCCTGTCGGGCCTGTGGTGCTGCGGCGCCGGTCATGGGCGGCGCGAGATCATTGAGGCGGTGAGCGCCCAGATC
GCCGCGCTTGATTACGCGCCGGCCTTCCAGTTCGGTCATCCCAGCTCGTTCAAACTAGCCAATAAGGTGGCGTCGCTGAC
CCCGAAGGGGCTCGATCATGTCTTTTTCACCAATTCCGGGTCGGAATCGGTCGATACGGCGCTGAAGATGGCGCGGGCCT
ATTGGCGGCTGAAGGGCGAGCCGGCGCGGACCAAGCTGATCGGCCGGGCCAAGGGCTATCACGGGGTGAACTTCGGCGGT
CTGGGCGTTGGCGGCATCGGCGGCAATCGCAAGCTGTTTGGCGTCGGCATCGATGCCGATCATCTGCCCCATACCATGCT
GCCCGAAAACGCCTTCACCAAGGGCTGTCCCGAGACCGGCGCCGAGCTGGCCGATGCCCTGGAGGATCTGGTGGCGCTCC
ATGACGCCTCCAATATCGCCGCGGTGATCGTCGAACCTTTGGCCGGATCGACCGGGGTACTGCCGCCGCCCAAGGGCTAT
CTGCAACGCCTGCGCGCCATCTGCGACAAATACGGCATCTTGCTGATTTTCGACGAGGTCATCACCGGCTTTGGCCGCAT
GGGCGCGGCCTTCGGCGCCGACGCCTTCGGCGTGGTTCCCGATATCATGACCATCGCCAAGGGGCTGACCAACGGCGCGG
TGCCGATGGGCGCCGTGGTCGCCAGCGGCGAGATCTATCGGACCTTCATGGAAAACTCCGGCCCCGATCATCTGGTGGAG
TTTCCCCACGGCTATACCTATTCGGCCCATCCGGTGGCCTGCGCCGCCGGCCTCGCCGCGCTTGAGATCTTTGAAAAGGA
CCAATTGGCCGCCCGGGCGGCGGCGCTGGCGCCCTATTTCGAAAACAGCCTGCATGGCCTGCGCGGCCTCAAGCACATCG
TCGATATCCGCAATTATGGTTTGGCCGGGGCGGTGCAGATCGAAAACGCCCCCGGTCAGCCGGCCAAAAGACCCCTGGAG
ATCGGCCGCAAATGTTGGGAGGCGGGCTATTACGTGCGCTTTGGCGGCGACAGCCTGCAATTCGGCCTGCCGTTCTTCAG
CGAACCCGCGCAGATCGACGGCCTGATGAACGCCGTCGCCGATGCCGTTTCCTCTGTCGCCTGA

Upstream 100 bases:

>100_bases
AACCCAGGGTATCCCCGCGTGCAGTCTGCTGTCCATCCCGCGCCGCCCCGGCCTTTGGCGCCCACTCCGGCGGAAGACCC
CTTTTTTGAGGATAGCCTTG

Downstream 100 bases:

>100_bases
CCGGTTTGGATCGCTTTCATGACCCTTGTGACTCATTTCATCAACGGCGCCGCCACCGCGCCGGCCGCCGGCCGTTGCCA
GGATATCGTCAACCCGGCGA

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSDFDPALAGGLSRAELEAHWMPFTANREFKANPRMVVGAEGVHYIDARGRKLYDSLSGLWCCGAGHGRREIIEAVSAQI
AALDYAPAFQFGHPSSFKLANKVASLTPKGLDHVFFTNSGSESVDTALKMARAYWRLKGEPARTKLIGRAKGYHGVNFGG
LGVGGIGGNRKLFGVGIDADHLPHTMLPENAFTKGCPETGAELADALEDLVALHDASNIAAVIVEPLAGSTGVLPPPKGY
LQRLRAICDKYGILLIFDEVITGFGRMGAAFGADAFGVVPDIMTIAKGLTNGAVPMGAVVASGEIYRTFMENSGPDHLVE
FPHGYTYSAHPVACAAGLAALEIFEKDQLAARAAALAPYFENSLHGLRGLKHIVDIRNYGLAGAVQIENAPGQPAKRPLE
IGRKCWEAGYYVRFGGDSLQFGLPFFSEPAQIDGLMNAVADAVSSVA

Sequences:

>Translated_447_residues
MSDFDPALAGGLSRAELEAHWMPFTANREFKANPRMVVGAEGVHYIDARGRKLYDSLSGLWCCGAGHGRREIIEAVSAQI
AALDYAPAFQFGHPSSFKLANKVASLTPKGLDHVFFTNSGSESVDTALKMARAYWRLKGEPARTKLIGRAKGYHGVNFGG
LGVGGIGGNRKLFGVGIDADHLPHTMLPENAFTKGCPETGAELADALEDLVALHDASNIAAVIVEPLAGSTGVLPPPKGY
LQRLRAICDKYGILLIFDEVITGFGRMGAAFGADAFGVVPDIMTIAKGLTNGAVPMGAVVASGEIYRTFMENSGPDHLVE
FPHGYTYSAHPVACAAGLAALEIFEKDQLAARAAALAPYFENSLHGLRGLKHIVDIRNYGLAGAVQIENAPGQPAKRPLE
IGRKCWEAGYYVRFGGDSLQFGLPFFSEPAQIDGLMNAVADAVSSVA
>Mature_446_residues
SDFDPALAGGLSRAELEAHWMPFTANREFKANPRMVVGAEGVHYIDARGRKLYDSLSGLWCCGAGHGRREIIEAVSAQIA
ALDYAPAFQFGHPSSFKLANKVASLTPKGLDHVFFTNSGSESVDTALKMARAYWRLKGEPARTKLIGRAKGYHGVNFGGL
GVGGIGGNRKLFGVGIDADHLPHTMLPENAFTKGCPETGAELADALEDLVALHDASNIAAVIVEPLAGSTGVLPPPKGYL
QRLRAICDKYGILLIFDEVITGFGRMGAAFGADAFGVVPDIMTIAKGLTNGAVPMGAVVASGEIYRTFMENSGPDHLVEF
PHGYTYSAHPVACAAGLAALEIFEKDQLAARAAALAPYFENSLHGLRGLKHIVDIRNYGLAGAVQIENAPGQPAKRPLEI
GRKCWEAGYYVRFGGDSLQFGLPFFSEPAQIDGLMNAVADAVSSVA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=392, Percent_Identity=29.0816326530612, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4557809, Length=359, Percent_Identity=27.8551532033426, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI37574042, Length=364, Percent_Identity=30.2197802197802, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226442705, Length=364, Percent_Identity=30.2197802197802, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI24119277, Length=364, Percent_Identity=27.4725274725275, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI284507298, Length=276, Percent_Identity=29.7101449275362, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI226442709, Length=328, Percent_Identity=31.4024390243902, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1786991, Length=436, Percent_Identity=31.4220183486239, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI145693181, Length=316, Percent_Identity=33.5443037974684, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789759, Length=437, Percent_Identity=29.2906178489703, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789016, Length=408, Percent_Identity=29.4117647058824, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1787560, Length=438, Percent_Identity=28.7671232876712, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=28.2442748091603, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786349, Length=325, Percent_Identity=29.5384615384615, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=384, Percent_Identity=30.2083333333333, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=26.8408551068884, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=382, Percent_Identity=27.7486910994764, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=245, Percent_Identity=31.0204081632653, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=381, Percent_Identity=28.3464566929134, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6324386, Length=367, Percent_Identity=28.3378746594005, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=24.8792270531401, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161085790, Length=407, Percent_Identity=29.4840294840295, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574759, Length=407, Percent_Identity=29.4840294840295, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=28.3653846153846, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21356575, Length=366, Percent_Identity=28.9617486338798, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47416; Mature: 47284

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFDPALAGGLSRAELEAHWMPFTANREFKANPRMVVGAEGVHYIDARGRKLYDSLSGL
CCCCCCHHHCCCCHHHHHEEECCEECCCCCCCCCCEEEECCCEEEECCCCHHHHHHHCCE
WCCGAGHGRREIIEAVSAQIAALDYAPAFQFGHPSSFKLANKVASLTPKGLDHVFFTNSG
EEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
SESVDTALKMARAYWRLKGEPARTKLIGRAKGYHGVNFGGLGVGGIGGNRKLFGVGIDAD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEECCCCC
HLPHTMLPENAFTKGCPETGAELADALEDLVALHDASNIAAVIVEPLAGSTGVLPPPKGY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LQRLRAICDKYGILLIFDEVITGFGRMGAAFGADAFGVVPDIMTIAKGLTNGAVPMGAVV
HHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
ASGEIYRTFMENSGPDHLVEFPHGYTYSAHPVACAAGLAALEIFEKDQLAARAAALAPYF
ECCHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSLHGLRGLKHIVDIRNYGLAGAVQIENAPGQPAKRPLEIGRKCWEAGYYVRFGGDSLQ
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEE
FGLPFFSEPAQIDGLMNAVADAVSSVA
ECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDFDPALAGGLSRAELEAHWMPFTANREFKANPRMVVGAEGVHYIDARGRKLYDSLSGL
CCCCCHHHCCCCHHHHHEEECCEECCCCCCCCCCEEEECCCEEEECCCCHHHHHHHCCE
WCCGAGHGRREIIEAVSAQIAALDYAPAFQFGHPSSFKLANKVASLTPKGLDHVFFTNSG
EEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
SESVDTALKMARAYWRLKGEPARTKLIGRAKGYHGVNFGGLGVGGIGGNRKLFGVGIDAD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEECCCCC
HLPHTMLPENAFTKGCPETGAELADALEDLVALHDASNIAAVIVEPLAGSTGVLPPPKGY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LQRLRAICDKYGILLIFDEVITGFGRMGAAFGADAFGVVPDIMTIAKGLTNGAVPMGAVV
HHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
ASGEIYRTFMENSGPDHLVEFPHGYTYSAHPVACAAGLAALEIFEKDQLAARAAALAPYF
ECCHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSLHGLRGLKHIVDIRNYGLAGAVQIENAPGQPAKRPLEIGRKCWEAGYYVRFGGDSLQ
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEE
FGLPFFSEPAQIDGLMNAVADAVSSVA
ECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]