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The map label for this gene is uvrD [H]

Identifier: 83592871

GI number: 83592871

Start: 1809079

End: 1811385

Strand: Direct

Name: uvrD [H]

Synonym: Rru_A1536

Alternate gene names: 83592871

Gene position: 1809079-1811385 (Clockwise)

Preceding gene: 83592869

Following gene: 83592876

Centisome position: 41.56

GC content: 67.49

Gene sequence:

>2307_bases
ATGGACGATCCCTTCGAGCTTGACGAGCCGTCGCCTCCCGCCCCCCGTTTCCAGGGAGCCGAGCCGCCGTGGCTTGCCGG
CCTTAATCCCGAGCAGCGCGCTGCCGTCACCACCACCGATGGCCCGGTGCTGGTGCTGTCGGGGGCGGGGACCGGCAAGA
CCCGGGTGCTGACGGCCCGCCTCGCCCAGATCCTGGCCACCCGGCCGGTGCGGCCCTGGCAGGTGCTGGCGGTGACCTTC
ACCAACCGCGCCGCCCGCGAGATGCGCGAGCGCGCCGGGGCGATGATCGGCCCCATGGCCGAACAGGTGTGGCTTGGCAC
TTTCCATGCCCTGGGCGTGCGCATGCTGCGCCGTCACGGCGATTTGGTCGGCTTGCGCTCGGGTTTCACCATTCTTGATG
CCGACGATCAACTGCGCCTGCTCAAGCAGATCCTGGAAGCCGAGGGGATCGATACCAAGAAATGGACGCCCCAGGCGGGG
ATGGGGCTGATCCAGCGCTGGAAGGACAAGGGGCTGCTGCCCGAGGCGGTTCCCGCCGGCGACGGCGGGCGGGAGTATGC
GGGCGGACGGGCGGTTGATCTGTACAAGCAGTATCAACAACGGCTGGCGGTGGTGAACGCCGCCGATTTCGGCGATCTGC
TGCTGCACTGCCTGACCATCTTCACCAAGCATCCCGATGTTCTGGCCGATTATTCCAAGATGTTTCACTACATCCTGGTC
GATGAGTATCAAGATACCAACGTCGCCCAATACCTGTGGCTGCGCCTGCTGGCGCGCGGCCATGGCAATATCTGCTGCGT
TGGCGATGACGATCAGTCGATCTATTCCTGGCGCGGCGCCGAGGTTGGCAACATCTTGCGCTTCGAGGCCGATTTCCCCG
GGGCGACGGTGGTGCGCCTGGAACGCAATTATCGCTCGACGCCGACCATTCTGGCCGCCGCCAGCGGCCTGATCCGCCAT
AACAAGGGGCGGCTGGGCAAGGATCTGCGGGCGGGGGAGGGCGACGAGGCCGGCGACGCGGTGATCGTGCGCGGGCTGTG
GGATGGCGAGGAGGAGGCGCGCCGGGTCGTCGATGACATCGAGACCCGCCAACGCGCCGGCGATCGCCTGAACGGCATGG
CGGTGCTGGTGCGTGCCGGCTTTCAGACCCGCGCCTTCGAAGAGCGGTTGATCCTGGCCGGCGTCCCCTATCGGGTGGTC
GGCGGCGCGCGTTTCTACGAGCGCCAGGAAATCCGCGACGCCATCGCCTATCTGCGTCTGGTCGCCCAACCCGACGACAG
CCTGGCCTTCGAGCGCATTATCAATCTGCCGCGCCGCGGCCTTGGCGATGCCAGTCTGCAGACGCTGATGCGGGCATCGC
GGATGGCCTCGATCAGCCTGATGCGCGCCGCCCGCGAGGCGATCGAGACCGACGAGTTGCGGCCCCAGGCCCGCAAGGCC
TTGCGCGCTTTCCTCGACGACATGGGGCGCTGGCGGTCCCTGGCCGATGCCATGGCGCCCGACGAACTCTGCGGGACGGT
GCTTGATGAAAGCGGCTATCTGGAGATGTGGCGCAAGGATAAATCGCCCGATGCCCAAGGCCGGGTGGAAAACCTCAAGG
AACTGGTTTCGGCGCTGAAGGAATTCGAAAGCCTGGGCGCCTTCCTGGAGCATGTGTCGCTGGTCATGGACAACGAGGCC
CGCGCCACCGAGGACGCGGTGACCCTGATGACGCTGCATGCGGCCAAGGGCCTGGAATTCGATACGGTCTTCCTGCCCGG
CTGGGAGGAGGAGATTTTCCCCCACCGCCGCGCCCTCGACGAAAACGGCGCCGAGGCCCTGGAGGAGGAGCGGCGCTTGG
CCTATGTCGGGCTGACCCGGGCGCGCAAACGGGCGATCATCAGCTTCGTCGCCAACCGCCGGGTCTATAACGAATGGCGG
GCCTGCCTGCCCAGCCGCTTCATCGACGAACTGCCGCCTGAGGTGGTCGAACGCGACAGCGCCAGCGGCGTTTACGGCTC
GGGCGCTCAAGGCTATGCCGACGCGCCCGGCGGCTGGGGGCGGCTGGGCGGTCCGGGAAGCTGGGGCGGTGGCTGGGGCA
ACGCCGCGCCGGCCCGCGTGCCGGCGGCGGGCGACACCCCGTGGCAAACCCGCGACCGCAGCGGCGACGACCAGCCGAGC
CTTCGCCCCGGGGACCGGGTGTTCCACGATAAATTCGGTGGGGGAACCGTTCTGGCCGCCGATCAGGGCCGGCTGGAGAT
CGATTTCGATAAGGCTGGCATCAAGAAGGTGATGGGGGGATTCGTCCGCAAAGCCGAGGGCACGTAA

Upstream 100 bases:

>100_bases
CGCAATCGGTGGCGCGACGGGCCGTGGGGCTTTCGTTGGGCGCCCCGCCTGCCTATTGTGGGGGAAACCCCGCTCCCCCT
GTTTTCATGATTACGGTGCC

Downstream 100 bases:

>100_bases
GGATCGCCCGCCCTTTTGGGGCGTTTGAGCCAAAGCCAACACCCCGCCGCCCGGCAATCAGGCGGCGGATGACCATGGCT
GGACGCGCGACGGTTTTCCT

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 768

Protein sequence:

>768_residues
MDDPFELDEPSPPAPRFQGAEPPWLAGLNPEQRAAVTTTDGPVLVLSGAGTGKTRVLTARLAQILATRPVRPWQVLAVTF
TNRAAREMRERAGAMIGPMAEQVWLGTFHALGVRMLRRHGDLVGLRSGFTILDADDQLRLLKQILEAEGIDTKKWTPQAG
MGLIQRWKDKGLLPEAVPAGDGGREYAGGRAVDLYKQYQQRLAVVNAADFGDLLLHCLTIFTKHPDVLADYSKMFHYILV
DEYQDTNVAQYLWLRLLARGHGNICCVGDDDQSIYSWRGAEVGNILRFEADFPGATVVRLERNYRSTPTILAAASGLIRH
NKGRLGKDLRAGEGDEAGDAVIVRGLWDGEEEARRVVDDIETRQRAGDRLNGMAVLVRAGFQTRAFEERLILAGVPYRVV
GGARFYERQEIRDAIAYLRLVAQPDDSLAFERIINLPRRGLGDASLQTLMRASRMASISLMRAAREAIETDELRPQARKA
LRAFLDDMGRWRSLADAMAPDELCGTVLDESGYLEMWRKDKSPDAQGRVENLKELVSALKEFESLGAFLEHVSLVMDNEA
RATEDAVTLMTLHAAKGLEFDTVFLPGWEEEIFPHRRALDENGAEALEEERRLAYVGLTRARKRAIISFVANRRVYNEWR
ACLPSRFIDELPPEVVERDSASGVYGSGAQGYADAPGGWGRLGGPGSWGGGWGNAAPARVPAAGDTPWQTRDRSGDDQPS
LRPGDRVFHDKFGGGTVLAADQGRLEIDFDKAGIKKVMGGFVRKAEGT

Sequences:

>Translated_768_residues
MDDPFELDEPSPPAPRFQGAEPPWLAGLNPEQRAAVTTTDGPVLVLSGAGTGKTRVLTARLAQILATRPVRPWQVLAVTF
TNRAAREMRERAGAMIGPMAEQVWLGTFHALGVRMLRRHGDLVGLRSGFTILDADDQLRLLKQILEAEGIDTKKWTPQAG
MGLIQRWKDKGLLPEAVPAGDGGREYAGGRAVDLYKQYQQRLAVVNAADFGDLLLHCLTIFTKHPDVLADYSKMFHYILV
DEYQDTNVAQYLWLRLLARGHGNICCVGDDDQSIYSWRGAEVGNILRFEADFPGATVVRLERNYRSTPTILAAASGLIRH
NKGRLGKDLRAGEGDEAGDAVIVRGLWDGEEEARRVVDDIETRQRAGDRLNGMAVLVRAGFQTRAFEERLILAGVPYRVV
GGARFYERQEIRDAIAYLRLVAQPDDSLAFERIINLPRRGLGDASLQTLMRASRMASISLMRAAREAIETDELRPQARKA
LRAFLDDMGRWRSLADAMAPDELCGTVLDESGYLEMWRKDKSPDAQGRVENLKELVSALKEFESLGAFLEHVSLVMDNEA
RATEDAVTLMTLHAAKGLEFDTVFLPGWEEEIFPHRRALDENGAEALEEERRLAYVGLTRARKRAIISFVANRRVYNEWR
ACLPSRFIDELPPEVVERDSASGVYGSGAQGYADAPGGWGRLGGPGSWGGGWGNAAPARVPAAGDTPWQTRDRSGDDQPS
LRPGDRVFHDKFGGGTVLAADQGRLEIDFDKAGIKKVMGGFVRKAEGT
>Mature_768_residues
MDDPFELDEPSPPAPRFQGAEPPWLAGLNPEQRAAVTTTDGPVLVLSGAGTGKTRVLTARLAQILATRPVRPWQVLAVTF
TNRAAREMRERAGAMIGPMAEQVWLGTFHALGVRMLRRHGDLVGLRSGFTILDADDQLRLLKQILEAEGIDTKKWTPQAG
MGLIQRWKDKGLLPEAVPAGDGGREYAGGRAVDLYKQYQQRLAVVNAADFGDLLLHCLTIFTKHPDVLADYSKMFHYILV
DEYQDTNVAQYLWLRLLARGHGNICCVGDDDQSIYSWRGAEVGNILRFEADFPGATVVRLERNYRSTPTILAAASGLIRH
NKGRLGKDLRAGEGDEAGDAVIVRGLWDGEEEARRVVDDIETRQRAGDRLNGMAVLVRAGFQTRAFEERLILAGVPYRVV
GGARFYERQEIRDAIAYLRLVAQPDDSLAFERIINLPRRGLGDASLQTLMRASRMASISLMRAAREAIETDELRPQARKA
LRAFLDDMGRWRSLADAMAPDELCGTVLDESGYLEMWRKDKSPDAQGRVENLKELVSALKEFESLGAFLEHVSLVMDNEA
RATEDAVTLMTLHAAKGLEFDTVFLPGWEEEIFPHRRALDENGAEALEEERRLAYVGLTRARKRAIISFVANRRVYNEWR
ACLPSRFIDELPPEVVERDSASGVYGSGAQGYADAPGGWGRLGGPGSWGGGWGNAAPARVPAAGDTPWQTRDRSGDDQPS
LRPGDRVFHDKFGGGTVLAADQGRLEIDFDKAGIKKVMGGFVRKAEGT

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=760, Percent_Identity=40.2631578947368, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI48994965, Length=647, Percent_Identity=36.1669242658423, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1787196, Length=344, Percent_Identity=26.7441860465116, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322369, Length=461, Percent_Identity=31.6702819956616, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 84840; Mature: 84840

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDPFELDEPSPPAPRFQGAEPPWLAGLNPEQRAAVTTTDGPVLVLSGAGTGKTRVLTAR
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHH
LAQILATRPVRPWQVLAVTFTNRAAREMRERAGAMIGPMAEQVWLGTFHALGVRMLRRHG
HHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHCC
DLVGLRSGFTILDADDQLRLLKQILEAEGIDTKKWTPQAGMGLIQRWKDKGLLPEAVPAG
CEEEECCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
DGGREYAGGRAVDLYKQYQQRLAVVNAADFGDLLLHCLTIFTKHPDVLADYSKMFHYILV
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEE
DEYQDTNVAQYLWLRLLARGHGNICCVGDDDQSIYSWRGAEVGNILRFEADFPGATVVRL
ECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCEEEEE
ERNYRSTPTILAAASGLIRHNKGRLGKDLRAGEGDEAGDAVIVRGLWDGEEEARRVVDDI
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
ETRQRAGDRLNGMAVLVRAGFQTRAFEERLILAGVPYRVVGGARFYERQEIRDAIAYLRL
HHHHHHCCHHCCEEEEEECCCHHHHHHHHHEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
VAQPDDSLAFERIINLPRRGLGDASLQTLMRASRMASISLMRAAREAIETDELRPQARKA
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LRAFLDDMGRWRSLADAMAPDELCGTVLDESGYLEMWRKDKSPDAQGRVENLKELVSALK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EFESLGAFLEHVSLVMDNEARATEDAVTLMTLHAAKGLEFDTVFLPGWEEEIFPHRRALD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHC
ENGAEALEEERRLAYVGLTRARKRAIISFVANRRVYNEWRACLPSRFIDELPPEVVERDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ASGVYGSGAQGYADAPGGWGRLGGPGSWGGGWGNAAPARVPAAGDTPWQTRDRSGDDQPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LRPGDRVFHDKFGGGTVLAADQGRLEIDFDKAGIKKVMGGFVRKAEGT
CCCCCHHHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDDPFELDEPSPPAPRFQGAEPPWLAGLNPEQRAAVTTTDGPVLVLSGAGTGKTRVLTAR
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHH
LAQILATRPVRPWQVLAVTFTNRAAREMRERAGAMIGPMAEQVWLGTFHALGVRMLRRHG
HHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHCC
DLVGLRSGFTILDADDQLRLLKQILEAEGIDTKKWTPQAGMGLIQRWKDKGLLPEAVPAG
CEEEECCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
DGGREYAGGRAVDLYKQYQQRLAVVNAADFGDLLLHCLTIFTKHPDVLADYSKMFHYILV
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEE
DEYQDTNVAQYLWLRLLARGHGNICCVGDDDQSIYSWRGAEVGNILRFEADFPGATVVRL
ECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCEEEEE
ERNYRSTPTILAAASGLIRHNKGRLGKDLRAGEGDEAGDAVIVRGLWDGEEEARRVVDDI
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
ETRQRAGDRLNGMAVLVRAGFQTRAFEERLILAGVPYRVVGGARFYERQEIRDAIAYLRL
HHHHHHCCHHCCEEEEEECCCHHHHHHHHHEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
VAQPDDSLAFERIINLPRRGLGDASLQTLMRASRMASISLMRAAREAIETDELRPQARKA
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LRAFLDDMGRWRSLADAMAPDELCGTVLDESGYLEMWRKDKSPDAQGRVENLKELVSALK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EFESLGAFLEHVSLVMDNEARATEDAVTLMTLHAAKGLEFDTVFLPGWEEEIFPHRRALD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHC
ENGAEALEEERRLAYVGLTRARKRAIISFVANRRVYNEWRACLPSRFIDELPPEVVERDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ASGVYGSGAQGYADAPGGWGRLGGPGSWGGGWGNAAPARVPAAGDTPWQTRDRSGDDQPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LRPGDRVFHDKFGGGTVLAADQGRLEIDFDKAGIKKVMGGFVRKAEGT
CCCCCHHHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA