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The map label for this gene is atoC [H]

Identifier: 83592721

GI number: 83592721

Start: 1634500

End: 1635882

Strand: Direct

Name: atoC [H]

Synonym: Rru_A1385

Alternate gene names: 83592721

Gene position: 1634500-1635882 (Clockwise)

Preceding gene: 83592720

Following gene: 83592722

Centisome position: 37.55

GC content: 63.34

Gene sequence:

>1383_bases
ATGTTAGCCCCCGCCCAGACCGTTCTGATCGTCGATGACGACGAGGCCATCCGCCAGATGCTGTCGGCCTTCTTGTCCAA
GGAAGGCCTGAGGGTGGTGACGGCGCGCGACGGCCTGGAGGCGATCGAGGTTTTCCGCCTTCAGCGTACCGATGTGGTTT
TGCTCGATATCCGCATGCCACGCATGAACGGCCTTGAGGCGGCCAAGGCGATCTTGGAGATGGACCGGGGCACGGCGGTG
ATCTTGATGACCGCCTTCGCCGAGGTTTGCACCGCGGTTCAGGCGATCAAGGATGGCGCCTTCGACTATGTGATCAAGCC
CTTTGATCTTGAGGAGATCCGCCTGCTCGTCCGCCGGGCGCTGGAGATCCGCTCGATGCGCGCCGATATCGTTTCATTGC
GGCGCGAATTATCCGAGCGTTACGGCGCCGAAGGTATCTTGACCGACAATCCCAAGATGATGGATCTGCGCCAGACCATC
GCCAAAGTGGCGCGCAGCCAAGCCACCGTGCTGATCCAGGGCGAAAGCGGCACCGGCAAGGAACTGGTGGCGGCCTCGGT
CCATTACGGCAGCCCGCGCGCCACCGGTCCCTTCATCCGCGTCAATTGCGCGGCCATTCCCGAAGGCTTGCTGGAAAGCG
AGTTCTTCGGCCACGAGAAGGGGGCCTTCACCGGGGCGGCCACCCGTCGGCGCGGGCGTTTTGAACAGGCCGAGCATGGC
ACGCTGTTTCTCGACGAGATCGGCGAGATTTCCCCGGCCCTTCAGGTCAAGCTGCTGCGGGTTCTGCAGGAACGCGAATA
CGAGCGCGTTGGCGGTTCGGAGCCGATCCCGGCCGATGTGCGCATCGTCGCGGCGACCAACCGCGATCTCGAGGCGATGA
TCCGCGAGGGAACCTTCCGTCAGGATCTGTTCTTCCGCCTGAATGTCGTCGCCTTGAAGACCATCCCCTTGCGCGATCGT
CCCGAGGATATCCGCCTGCTCGCCGATCATTTTCTTGGGCGCTTCGCCGCCGATAACAACGTGGTGATCCGGGGCTTCGA
TCCGGCGGCCTTGGACTGCATGCTGGCCTATCCCTGGCCCGGCAATGTCCGCGAATTGGTCAACGCCGTGGAGCGCGCCG
TGGTGATGAGCACGGGCAACGTGATTTTGCGCGACGATCTGCCCGAAAACATCATTTGCGGCGAGCGCGCCGCTTTCGTT
TCCGAACTGCTGCCCGATGGCGAGGCGATCAGGCCCTTGCGCGAAATGGCCAGCGAGTTCGAAACCCGCGTCATCCGCCT
CGCCCTGGCGCGCAACGGCGGCAACCGGGCGCGCACGGCGATTCAACTGGGGATCAGCCGTCGCGCCCTGCTTTATAAGC
TGCAGGAATACGCCATCACCTGA

Upstream 100 bases:

>100_bases
ATGCCCATCAGGGCGTCATCACCCTTGATAGCCGCCTTGGCGAGGGAACGGTGGTGACCATCCGCCTGCCCGTGGTTCGT
TCGAAGCAGGAGAGTCCCCC

Downstream 100 bases:

>100_bases
GCGCGCGACAGCGGCGCCGCGTCAGGGTGTTTCGGGAGCGCGCGGCATTTTTGCGTGACGGCGGACGGATTCGTGGTATC
TCATCGCATCGGGCAGCACG

Product: acetoacetate metabolism regulatory protein AtoC

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLAPAQTVLIVDDDEAIRQMLSAFLSKEGLRVVTARDGLEAIEVFRLQRTDVVLLDIRMPRMNGLEAAKAILEMDRGTAV
ILMTAFAEVCTAVQAIKDGAFDYVIKPFDLEEIRLLVRRALEIRSMRADIVSLRRELSERYGAEGILTDNPKMMDLRQTI
AKVARSQATVLIQGESGTGKELVAASVHYGSPRATGPFIRVNCAAIPEGLLESEFFGHEKGAFTGAATRRRGRFEQAEHG
TLFLDEIGEISPALQVKLLRVLQEREYERVGGSEPIPADVRIVAATNRDLEAMIREGTFRQDLFFRLNVVALKTIPLRDR
PEDIRLLADHFLGRFAADNNVVIRGFDPAALDCMLAYPWPGNVRELVNAVERAVVMSTGNVILRDDLPENIICGERAAFV
SELLPDGEAIRPLREMASEFETRVIRLALARNGGNRARTAIQLGISRRALLYKLQEYAIT

Sequences:

>Translated_460_residues
MLAPAQTVLIVDDDEAIRQMLSAFLSKEGLRVVTARDGLEAIEVFRLQRTDVVLLDIRMPRMNGLEAAKAILEMDRGTAV
ILMTAFAEVCTAVQAIKDGAFDYVIKPFDLEEIRLLVRRALEIRSMRADIVSLRRELSERYGAEGILTDNPKMMDLRQTI
AKVARSQATVLIQGESGTGKELVAASVHYGSPRATGPFIRVNCAAIPEGLLESEFFGHEKGAFTGAATRRRGRFEQAEHG
TLFLDEIGEISPALQVKLLRVLQEREYERVGGSEPIPADVRIVAATNRDLEAMIREGTFRQDLFFRLNVVALKTIPLRDR
PEDIRLLADHFLGRFAADNNVVIRGFDPAALDCMLAYPWPGNVRELVNAVERAVVMSTGNVILRDDLPENIICGERAAFV
SELLPDGEAIRPLREMASEFETRVIRLALARNGGNRARTAIQLGISRRALLYKLQEYAIT
>Mature_460_residues
MLAPAQTVLIVDDDEAIRQMLSAFLSKEGLRVVTARDGLEAIEVFRLQRTDVVLLDIRMPRMNGLEAAKAILEMDRGTAV
ILMTAFAEVCTAVQAIKDGAFDYVIKPFDLEEIRLLVRRALEIRSMRADIVSLRRELSERYGAEGILTDNPKMMDLRQTI
AKVARSQATVLIQGESGTGKELVAASVHYGSPRATGPFIRVNCAAIPEGLLESEFFGHEKGAFTGAATRRRGRFEQAEHG
TLFLDEIGEISPALQVKLLRVLQEREYERVGGSEPIPADVRIVAATNRDLEAMIREGTFRQDLFFRLNVVALKTIPLRDR
PEDIRLLADHFLGRFAADNNVVIRGFDPAALDCMLAYPWPGNVRELVNAVERAVVMSTGNVILRDDLPENIICGERAAFV
SELLPDGEAIRPLREMASEFETRVIRLALARNGGNRARTAIQLGISRRALLYKLQEYAIT

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=55.6043956043956, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=48.6666666666667, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=42.8265524625268, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=41.019955654102, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI87082117, Length=445, Percent_Identity=41.3483146067416, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI87082152, Length=301, Percent_Identity=45.8471760797342, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1789087, Length=240, Percent_Identity=50, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789233, Length=313, Percent_Identity=43.1309904153355, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=42.1538461538462, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786524, Length=340, Percent_Identity=42.0588235294118, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=40.0621118012422, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1789828, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=312, Percent_Identity=30.7692307692308, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=37.5, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=114, Percent_Identity=32.4561403508772, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=235, Percent_Identity=24.2553191489362, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790863, Length=142, Percent_Identity=30.2816901408451, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=117, Percent_Identity=34.1880341880342, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51182; Mature: 51182

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAPAQTVLIVDDDEAIRQMLSAFLSKEGLRVVTARDGLEAIEVFRLQRTDVVLLDIRMP
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEECC
RMNGLEAAKAILEMDRGTAVILMTAFAEVCTAVQAIKDGAFDYVIKPFDLEEIRLLVRRA
CCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
LEIRSMRADIVSLRRELSERYGAEGILTDNPKMMDLRQTIAKVARSQATVLIQGESGTGK
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
ELVAASVHYGSPRATGPFIRVNCAAIPEGLLESEFFGHEKGAFTGAATRRRGRFEQAEHG
HHEEEEEECCCCCCCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCC
TLFLDEIGEISPALQVKLLRVLQEREYERVGGSEPIPADVRIVAATNRDLEAMIREGTFR
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHCCCCH
QDLFFRLNVVALKTIPLRDRPEDIRLLADHFLGRFAADNNVVIRGFDPAALDCMLAYPWP
HHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEEEECCCC
GNVRELVNAVERAVVMSTGNVILRDDLPENIICGERAAFVSELLPDGEAIRPLREMASEF
CCHHHHHHHHHHHHEEECCCEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
ETRVIRLALARNGGNRARTAIQLGISRRALLYKLQEYAIT
HHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAPAQTVLIVDDDEAIRQMLSAFLSKEGLRVVTARDGLEAIEVFRLQRTDVVLLDIRMP
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEECC
RMNGLEAAKAILEMDRGTAVILMTAFAEVCTAVQAIKDGAFDYVIKPFDLEEIRLLVRRA
CCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH
LEIRSMRADIVSLRRELSERYGAEGILTDNPKMMDLRQTIAKVARSQATVLIQGESGTGK
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
ELVAASVHYGSPRATGPFIRVNCAAIPEGLLESEFFGHEKGAFTGAATRRRGRFEQAEHG
HHEEEEEECCCCCCCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCC
TLFLDEIGEISPALQVKLLRVLQEREYERVGGSEPIPADVRIVAATNRDLEAMIREGTFR
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHCCCCH
QDLFFRLNVVALKTIPLRDRPEDIRLLADHFLGRFAADNNVVIRGFDPAALDCMLAYPWP
HHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEEEECCCC
GNVRELVNAVERAVVMSTGNVILRDDLPENIICGERAAFVSELLPDGEAIRPLREMASEF
CCHHHHHHHHHHHHEEECCCEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
ETRVIRLALARNGGNRARTAIQLGISRRALLYKLQEYAIT
HHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]