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The map label for this gene is hoxA [H]

Identifier: 83592506

GI number: 83592506

Start: 1386259

End: 1387704

Strand: Direct

Name: hoxA [H]

Synonym: Rru_A1170

Alternate gene names: 83592506

Gene position: 1386259-1387704 (Clockwise)

Preceding gene: 83592505

Following gene: 83592507

Centisome position: 31.85

GC content: 69.5

Gene sequence:

>1446_bases
ATGACGGAACGGCCGCTTATTTTGGTAGTGGAGGGAGAGTCCCGAACCCGGGGGGCGCTGATCGGCGCCCTCGGCGAGCG
GTTCCGCGTGCTTGCCGCCGAAGATCCGCCGCAGGCCGAACGGCTGCTTGCCGAAAAGGACGTTCAGGCCATTTTGTGCG
ATCAGACCCTGGCCGGCGGCGGCGTGGCCTTTTTGCGTGGCGTGCGGGCGCGCTGGCCCGAACCGGTGCGGCTGATCCTG
GCCGAGGCCGCCGCCGCCCGCGAAATGGCCCTGGCCGTCGACGAGGCCTGGATCCACCAATCGATCGTCAAGCCCTGGAC
GGCCGAGACCCTGGCCCAGACGCTGGGCAACGCCGTTCGCCTGTATCGCCTGCGCCGCGACAACAAGGCGGTGTCGCTGC
GCATGCGCGACGCGCCGGGCCTCCACGACCGGGCGGGGGAGCGCCGCCACCGCGCCGCCGGCCGCGACCAGGGCTTCGAC
AGCCTGCTGCACGCGGCGGGAAGCCCGCTGGCCGTCGCCATCGCCCTGGCCAGAAAGGTTGCGCGCTTTGATATCTCCGT
GCTGCTGACCGGCGAAAGCGGCACCGGCAAGGAACTGCTCGCCCGCGCCATTCATCGCGGTTCGCCGCGCGCCGCCCGCC
GCTTCGTCGTTGAGAACTGCGGCGCCTTGCCCGACCAATTGTTGGAAAGCGAATTGTTCGGCTGCAAAAAGGGCGCCTAT
ACCGGCGCCCATGAGGATCGGGTCGGGCTGTTCGAACTGGCCGATGGCGGCACGATTTTCCTTGATGAGATCGGCGAGAC
CTCGCCGGCCTTTCAGGTCAAGCTGCTGCGCGTGCTTCAGGAGGGCGAAATCCGCCCGCTGGGGTCCAGCCTGACCCGCA
AGGTCGATGTGCGGGTGATCGCCGCCACCAACCGCGATCTGGAAAGCGAGGTGGCCAAAGGGCGCTTTCGCCGCGACCTG
TTCTACCGGCTGGCCGGCTTTCCCTTGCACCTGCCGGCCCTGCGCGAACGGCCGATGGATGTGCCGCTGCTTGCCGAGGC
CTTCATGGGCGAAAGCATGCGGTTCCTGGGCAAGCCGGTGGAAGGCCTGAGCGACGGGGCATTGACCCGGCTGCGCCGCC
ACGACTGGCCGGGCAACGTTCGCGAACTGCAAAACGAGATCCAGCGGATGATCGCCCTGGCCGATGGGCCGCTGCTGACC
GAGGATCTGGCCTCGCCCAAGGTCGGAGCGGCCAGGGCCGAGGCCTTGGGTGGCGGGGTGGCGGCGAGCGGCCCGCTCAA
GGAGCGGGTGGAGGCCCTGGAAGCCGCCGTCATCGCCGAAGGGCTGGCCCGCCCGGGCTGCACGCTCAGCCGTTTGGCCG
CCGATCTGGGGCTGTCACGGGTTGGGCTGCGCGCCAAGATGCGCCGCTACGGGCTTGATCAGGCGGTGCCCGACGGCGAG
TCCTAA

Upstream 100 bases:

>100_bases
TGGTATGCCTGGATCCGCGCTGAACGGGCCGCCCGCACGCCGCCGAAGGACGATTAATGTCCGCCTTTCCCCGGGAAGGG
GAGAAGGTTATCCTCGGGCG

Downstream 100 bases:

>100_bases
GCGCCGAAATTTGGCTGGTCCACCTTTGAGAAGAAATCTTAATTCACGAGTCAGTTTTTTAACCCATAAAAGTTATAGAC
AATATAGACAAACAAGGGCG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTERPLILVVEGESRTRGALIGALGERFRVLAAEDPPQAERLLAEKDVQAILCDQTLAGGGVAFLRGVRARWPEPVRLIL
AEAAAAREMALAVDEAWIHQSIVKPWTAETLAQTLGNAVRLYRLRRDNKAVSLRMRDAPGLHDRAGERRHRAAGRDQGFD
SLLHAAGSPLAVAIALARKVARFDISVLLTGESGTGKELLARAIHRGSPRAARRFVVENCGALPDQLLESELFGCKKGAY
TGAHEDRVGLFELADGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGSSLTRKVDVRVIAATNRDLESEVAKGRFRRDL
FYRLAGFPLHLPALRERPMDVPLLAEAFMGESMRFLGKPVEGLSDGALTRLRRHDWPGNVRELQNEIQRMIALADGPLLT
EDLASPKVGAARAEALGGGVAASGPLKERVEALEAAVIAEGLARPGCTLSRLAADLGLSRVGLRAKMRRYGLDQAVPDGE
S

Sequences:

>Translated_481_residues
MTERPLILVVEGESRTRGALIGALGERFRVLAAEDPPQAERLLAEKDVQAILCDQTLAGGGVAFLRGVRARWPEPVRLIL
AEAAAAREMALAVDEAWIHQSIVKPWTAETLAQTLGNAVRLYRLRRDNKAVSLRMRDAPGLHDRAGERRHRAAGRDQGFD
SLLHAAGSPLAVAIALARKVARFDISVLLTGESGTGKELLARAIHRGSPRAARRFVVENCGALPDQLLESELFGCKKGAY
TGAHEDRVGLFELADGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGSSLTRKVDVRVIAATNRDLESEVAKGRFRRDL
FYRLAGFPLHLPALRERPMDVPLLAEAFMGESMRFLGKPVEGLSDGALTRLRRHDWPGNVRELQNEIQRMIALADGPLLT
EDLASPKVGAARAEALGGGVAASGPLKERVEALEAAVIAEGLARPGCTLSRLAADLGLSRVGLRAKMRRYGLDQAVPDGE
S
>Mature_480_residues
TERPLILVVEGESRTRGALIGALGERFRVLAAEDPPQAERLLAEKDVQAILCDQTLAGGGVAFLRGVRARWPEPVRLILA
EAAAAREMALAVDEAWIHQSIVKPWTAETLAQTLGNAVRLYRLRRDNKAVSLRMRDAPGLHDRAGERRHRAAGRDQGFDS
LLHAAGSPLAVAIALARKVARFDISVLLTGESGTGKELLARAIHRGSPRAARRFVVENCGALPDQLLESELFGCKKGAYT
GAHEDRVGLFELADGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGSSLTRKVDVRVIAATNRDLESEVAKGRFRRDLF
YRLAGFPLHLPALRERPMDVPLLAEAFMGESMRFLGKPVEGLSDGALTRLRRHDWPGNVRELQNEIQRMIALADGPLLTE
DLASPKVGAARAEALGGGVAASGPLKERVEALEAAVIAEGLARPGCTLSRLAADLGLSRVGLRAKMRRYGLDQAVPDGES

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=485, Percent_Identity=35.6701030927835, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788905, Length=227, Percent_Identity=51.9823788546256, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789087, Length=299, Percent_Identity=46.8227424749164, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790437, Length=478, Percent_Identity=35.3556485355649, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI87082117, Length=217, Percent_Identity=56.221198156682, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082152, Length=300, Percent_Identity=46.6666666666667, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1790299, Length=413, Percent_Identity=36.8038740920097, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1789233, Length=313, Percent_Identity=39.6166134185303, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1787583, Length=332, Percent_Identity=39.1566265060241, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786524, Length=224, Percent_Identity=48.6607142857143, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=37.888198757764, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081858, Length=313, Percent_Identity=34.185303514377, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789828, Length=326, Percent_Identity=33.7423312883436, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52115; Mature: 51984

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERPLILVVEGESRTRGALIGALGERFRVLAAEDPPQAERLLAEKDVQAILCDQTLAGG
CCCCCEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
GVAFLRGVRARWPEPVRLILAEAAAAREMALAVDEAWIHQSIVKPWTAETLAQTLGNAVR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LYRLRRDNKAVSLRMRDAPGLHDRAGERRHRAAGRDQGFDSLLHAAGSPLAVAIALARKV
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
ARFDISVLLTGESGTGKELLARAIHRGSPRAARRFVVENCGALPDQLLESELFGCKKGAY
HHCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TGAHEDRVGLFELADGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGSSLTRKVDVRVI
CCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCEEEEEEE
AATNRDLESEVAKGRFRRDLFYRLAGFPLHLPALRERPMDVPLLAEAFMGESMRFLGKPV
EECCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCCCCHHHHHHHHCCHHHHHCCCC
EGLSDGALTRLRRHDWPGNVRELQNEIQRMIALADGPLLTEDLASPKVGAARAEALGGGV
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHCCCC
AASGPLKERVEALEAAVIAEGLARPGCTLSRLAADLGLSRVGLRAKMRRYGLDQAVPDGE
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
S
C
>Mature Secondary Structure 
TERPLILVVEGESRTRGALIGALGERFRVLAAEDPPQAERLLAEKDVQAILCDQTLAGG
CCCCEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
GVAFLRGVRARWPEPVRLILAEAAAAREMALAVDEAWIHQSIVKPWTAETLAQTLGNAVR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LYRLRRDNKAVSLRMRDAPGLHDRAGERRHRAAGRDQGFDSLLHAAGSPLAVAIALARKV
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
ARFDISVLLTGESGTGKELLARAIHRGSPRAARRFVVENCGALPDQLLESELFGCKKGAY
HHCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TGAHEDRVGLFELADGGTIFLDEIGETSPAFQVKLLRVLQEGEIRPLGSSLTRKVDVRVI
CCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCEEEEEEE
AATNRDLESEVAKGRFRRDLFYRLAGFPLHLPALRERPMDVPLLAEAFMGESMRFLGKPV
EECCCCHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCCCCHHHHHHHHCCHHHHHCCCC
EGLSDGALTRLRRHDWPGNVRELQNEIQRMIALADGPLLTEDLASPKVGAARAEALGGGV
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHCCCC
AASGPLKERVEALEAAVIAEGLARPGCTLSRLAADLGLSRVGLRAKMRRYGLDQAVPDGE
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8510650; 12597275 [H]