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The map label for this gene is uvrB [H]

Identifier: 83592469

GI number: 83592469

Start: 1335113

End: 1337314

Strand: Reverse

Name: uvrB [H]

Synonym: Rru_A1133

Alternate gene names: 83592469

Gene position: 1337314-1335113 (Counterclockwise)

Preceding gene: 83592477

Following gene: 83592468

Centisome position: 30.72

GC content: 65.3

Gene sequence:

>2202_bases
ATGACGGACGGCGCGCCCCCCTGGTCAAGCCCGGGCGGGCGGCTTATCTTAAGGGCCATGACCATGCTTCTCCCCCTGTT
CGAGCGCCCGCCCGCTGGCCCCCGCGCCGAGTTTCGTCTGGCCAGCGACTATCAGCCCGCCGGCGATCAGCCCCAGGCCA
TCGCCGAGCTGTTGCGGGGTCTGGCCGCCCAAGACCGCGATCAGGTGCTGCTGGGCGTCACCGGCTCGGGCAAGACCTTC
ACCATGGCCCAGGTCATCGCCGAGATGGGCCGGCCGACCCTGATCCTCGCCCCCAACAAAACCCTGGCCGCCCAGCTTTA
CGGCGAGTTCAAGAATTTCTTTCCCGACAACGCCGTCGAGTATTTCGTCAGCTATTACGACTATTACCAGCCCGAAGCCT
ATGTTCCGCGCACCGATACCTATATCGAAAAAGACTCCAGCATCAACGAGCAGATTGACCGGATGCGCCACGCCGCCACC
CGCGCCCTGCTTGAACGCCGCGATGTCATCATCGTCGCCTCGGTCTCGTGCATCTATGGTATCGGCTCGGTCGAGTCCTA
TTCCCGGATGATCATCCCCATCAAGGTGGGAACGACGCTGCCGCGCGCCGATCTGCTCAAGGCGCTGGTCGAGCTGCAGT
TCACCCGCAATGACATCGCCTTCACCCGGGGTATGTTCCGGGTGCGCGGGGATTCGGTGGAGATCTTCCCCGCCCACTAT
GAGGACCGCGCCTGGCGGGTCAGCCTGTGGGGGGACGAGATCGAATCCGTGCGCGAATTCGATCCCTTGACCGGCGAGAT
CACCGCCAGCCTCGACGAAGTCACCGTCTATCCGGCCAGCCACCATGTCACCCCCCGCCCGGCGCTGTCCCAGGCGGTGC
GCACGATCAAGGCCGAGCTCAAGGAAACGCTCGCCCGCTTTTACGACCAGGGCAAGGTGCTTGAGGCCCAGCGCCTGGAG
CAGCGCACCACCTTCGATCTGGAGATGATCGAGGCGACCGGCCACTGCAAGTCCATCGAGAACTACTCACGCCATCTGAC
CGGACGCCGCCCCGGCGATCCGCCGCCGACCCTGTTCGAATACCTGCCCGAGGACGCCTTGCTGTTCGTCGATGAAAGCC
ACGTCGCCGTGCCGCAGATCGGCGGCATGTTCCGCGGCGACTTCAATCGCAAAAGCGTGCTGGCGGAATTCGGCTTCCGC
CTGCCGTCCTGCGTTGATAACCGGCCGCTGAAGTTCGAGGAATGGGACGTCATGCGCCCGCCGTCGATCTTCGTTTCGGC
CACCCCGGGGCGCTGGGAACTTGAACGCACCGGCGGCGTCGTCGCCGAACAGGTGATCCGCCCCACCGGTCTGGTCGATC
CGGTCTGCATCATCCGCCCGGTCGAGGCCCAGGTCGACGATCTGCTGGGCGAGGTCAAGGCCTGCGCGGCGCGCGGCGAA
CGGGTGCTGGTCACCACCTTGACCAAGCGCATGTCCGAGGATCTGACCGAATATCTGACCGAACAGGGGGTAAGGGTGCG
CTACATGCACTCCGACATCGAAACCCTGGAGCGGATCGAGATCATCCGCGACCTGCGGCTGGGCGCCTTCGATGTGCTGG
TCGGCATCAACCTGCTGCGCGAGGGCCTTGATATCCCCGAATGCGCCCTGGTGGCGATCTTGGACGCCGATAAGGAAGGC
TTCCTGCGCTCGCGCACCTCGCTGATCCAGACCATCGGCCGCGCCGCCCGTAACGTTGGCGGCCGGGTGATCCTTTATGC
CGACAAGATGACCGATTCCCTGACCTTCGCCATCGAGGAAACCAGCCGCCGCCGCCAGCGTCAGCAAGACTACAACGCCG
CCCATGGCATCACCCCGGAAACCGTGCGCTCGCGCATTTCCGATGTTCTCAGCAGCGTTTACGAAAAAGACTACGTCACC
GTGACCACCGGGGTATCGGGCGACAACCAACTGGTCGGCAAATCCCTGCGCGAGCATCTCGCCGATCTCGACAAACGCAT
GCGCGCCGCCGCCGCCGATCTGGAATTCGAGGAGGCCGGCCGCCTGCGCGACGAGATCCGCCGCCTGGAGGCGCTGGACC
TTGGCCTGCCCGGAGACGCCGGGGCGACCGGCCTTGCCGAAGCCGCCATCCCCTTGCGCGCCGCCGTCGCCAAAGGCCGG
GGGGCAGCGGCCAAGGGCCGTGGTCGCAAGGGCAAAAGGTGA

Upstream 100 bases:

>100_bases
GCCCGCCCCCTTCAGCGTGGCGATCATAAGGCAGGCCCGGGACGATTTGGCAAGCCGGGCGCTGTGGCGGTCCTTTTGAA
ATGGGTCGAAAAAGGGAGCG

Downstream 100 bases:

>100_bases
AAAGAAGCCGCAGCCCTTGTCCCTTCATATCCGCCCCATCGCCTTTGCCGACCCGCTGACCCTGGTCCCGGCCTTGGCCA
AGGATCCGGTCTTCGCCTTT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MTDGAPPWSSPGGRLILRAMTMLLPLFERPPAGPRAEFRLASDYQPAGDQPQAIAELLRGLAAQDRDQVLLGVTGSGKTF
TMAQVIAEMGRPTLILAPNKTLAAQLYGEFKNFFPDNAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHAAT
RALLERRDVIIVASVSCIYGIGSVESYSRMIIPIKVGTTLPRADLLKALVELQFTRNDIAFTRGMFRVRGDSVEIFPAHY
EDRAWRVSLWGDEIESVREFDPLTGEITASLDEVTVYPASHHVTPRPALSQAVRTIKAELKETLARFYDQGKVLEAQRLE
QRTTFDLEMIEATGHCKSIENYSRHLTGRRPGDPPPTLFEYLPEDALLFVDESHVAVPQIGGMFRGDFNRKSVLAEFGFR
LPSCVDNRPLKFEEWDVMRPPSIFVSATPGRWELERTGGVVAEQVIRPTGLVDPVCIIRPVEAQVDDLLGEVKACAARGE
RVLVTTLTKRMSEDLTEYLTEQGVRVRYMHSDIETLERIEIIRDLRLGAFDVLVGINLLREGLDIPECALVAILDADKEG
FLRSRTSLIQTIGRAARNVGGRVILYADKMTDSLTFAIEETSRRRQRQQDYNAAHGITPETVRSRISDVLSSVYEKDYVT
VTTGVSGDNQLVGKSLREHLADLDKRMRAAAADLEFEEAGRLRDEIRRLEALDLGLPGDAGATGLAEAAIPLRAAVAKGR
GAAAKGRGRKGKR

Sequences:

>Translated_733_residues
MTDGAPPWSSPGGRLILRAMTMLLPLFERPPAGPRAEFRLASDYQPAGDQPQAIAELLRGLAAQDRDQVLLGVTGSGKTF
TMAQVIAEMGRPTLILAPNKTLAAQLYGEFKNFFPDNAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHAAT
RALLERRDVIIVASVSCIYGIGSVESYSRMIIPIKVGTTLPRADLLKALVELQFTRNDIAFTRGMFRVRGDSVEIFPAHY
EDRAWRVSLWGDEIESVREFDPLTGEITASLDEVTVYPASHHVTPRPALSQAVRTIKAELKETLARFYDQGKVLEAQRLE
QRTTFDLEMIEATGHCKSIENYSRHLTGRRPGDPPPTLFEYLPEDALLFVDESHVAVPQIGGMFRGDFNRKSVLAEFGFR
LPSCVDNRPLKFEEWDVMRPPSIFVSATPGRWELERTGGVVAEQVIRPTGLVDPVCIIRPVEAQVDDLLGEVKACAARGE
RVLVTTLTKRMSEDLTEYLTEQGVRVRYMHSDIETLERIEIIRDLRLGAFDVLVGINLLREGLDIPECALVAILDADKEG
FLRSRTSLIQTIGRAARNVGGRVILYADKMTDSLTFAIEETSRRRQRQQDYNAAHGITPETVRSRISDVLSSVYEKDYVT
VTTGVSGDNQLVGKSLREHLADLDKRMRAAAADLEFEEAGRLRDEIRRLEALDLGLPGDAGATGLAEAAIPLRAAVAKGR
GAAAKGRGRKGKR
>Mature_732_residues
TDGAPPWSSPGGRLILRAMTMLLPLFERPPAGPRAEFRLASDYQPAGDQPQAIAELLRGLAAQDRDQVLLGVTGSGKTFT
MAQVIAEMGRPTLILAPNKTLAAQLYGEFKNFFPDNAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHAATR
ALLERRDVIIVASVSCIYGIGSVESYSRMIIPIKVGTTLPRADLLKALVELQFTRNDIAFTRGMFRVRGDSVEIFPAHYE
DRAWRVSLWGDEIESVREFDPLTGEITASLDEVTVYPASHHVTPRPALSQAVRTIKAELKETLARFYDQGKVLEAQRLEQ
RTTFDLEMIEATGHCKSIENYSRHLTGRRPGDPPPTLFEYLPEDALLFVDESHVAVPQIGGMFRGDFNRKSVLAEFGFRL
PSCVDNRPLKFEEWDVMRPPSIFVSATPGRWELERTGGVVAEQVIRPTGLVDPVCIIRPVEAQVDDLLGEVKACAARGER
VLVTTLTKRMSEDLTEYLTEQGVRVRYMHSDIETLERIEIIRDLRLGAFDVLVGINLLREGLDIPECALVAILDADKEGF
LRSRTSLIQTIGRAARNVGGRVILYADKMTDSLTFAIEETSRRRQRQQDYNAAHGITPETVRSRISDVLSSVYEKDYVTV
TTGVSGDNQLVGKSLREHLADLDKRMRAAAADLEFEEAGRLRDEIRRLEALDLGLPGDAGATGLAEAAIPLRAAVAKGRG
AAAKGRGRKGKR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=59.2481203007519, Blast_Score=790, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 81688; Mature: 81557

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGAPPWSSPGGRLILRAMTMLLPLFERPPAGPRAEFRLASDYQPAGDQPQAIAELLRG
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
LAAQDRDQVLLGVTGSGKTFTMAQVIAEMGRPTLILAPNKTLAAQLYGEFKNFFPDNAVE
HHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHH
YFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHAATRALLERRDVIIVASVSCIYG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHC
IGSVESYSRMIIPIKVGTTLPRADLLKALVELQFTRNDIAFTRGMFRVRGDSVEIFPAHY
CCCHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCEEEEECCCEEEEECCC
EDRAWRVSLWGDEIESVREFDPLTGEITASLDEVTVYPASHHVTPRPALSQAVRTIKAEL
CCCEEEEEECCHHHHHHHHCCCCCCHHEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
KETLARFYDQGKVLEAQRLEQRTTFDLEMIEATGHCKSIENYSRHLTGRRPGDPPPTLFE
HHHHHHHHCCCCCHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHH
YLPEDALLFVDESHVAVPQIGGMFRGDFNRKSVLAEFGFRLPSCVDNRPLKFEEWDVMRP
HCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PSIFVSATPGRWELERTGGVVAEQVIRPTGLVDPVCIIRPVEAQVDDLLGEVKACAARGE
CCEEEECCCCCEEEHHHCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCC
RVLVTTLTKRMSEDLTEYLTEQGVRVRYMHSDIETLERIEIIRDLRLGAFDVLVGINLLR
EEEHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EGLDIPECALVAILDADKEGFLRSRTSLIQTIGRAARNVGGRVILYADKMTDSLTFAIEE
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHH
TSRRRQRQQDYNAAHGITPETVRSRISDVLSSVYEKDYVTVTTGVSGDNQLVGKSLREHL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
ADLDKRMRAAAADLEFEEAGRLRDEIRRLEALDLGLPGDAGATGLAEAAIPLRAAVAKGR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
GAAAKGRGRKGKR
CCCCCCCCCCCCC
>Mature Secondary Structure 
TDGAPPWSSPGGRLILRAMTMLLPLFERPPAGPRAEFRLASDYQPAGDQPQAIAELLRG
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
LAAQDRDQVLLGVTGSGKTFTMAQVIAEMGRPTLILAPNKTLAAQLYGEFKNFFPDNAVE
HHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHH
YFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHAATRALLERRDVIIVASVSCIYG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHC
IGSVESYSRMIIPIKVGTTLPRADLLKALVELQFTRNDIAFTRGMFRVRGDSVEIFPAHY
CCCHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCEEEEECCCEEEEECCC
EDRAWRVSLWGDEIESVREFDPLTGEITASLDEVTVYPASHHVTPRPALSQAVRTIKAEL
CCCEEEEEECCHHHHHHHHCCCCCCHHEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
KETLARFYDQGKVLEAQRLEQRTTFDLEMIEATGHCKSIENYSRHLTGRRPGDPPPTLFE
HHHHHHHHCCCCCHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHH
YLPEDALLFVDESHVAVPQIGGMFRGDFNRKSVLAEFGFRLPSCVDNRPLKFEEWDVMRP
HCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PSIFVSATPGRWELERTGGVVAEQVIRPTGLVDPVCIIRPVEAQVDDLLGEVKACAARGE
CCEEEECCCCCEEEHHHCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCC
RVLVTTLTKRMSEDLTEYLTEQGVRVRYMHSDIETLERIEIIRDLRLGAFDVLVGINLLR
EEEHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EGLDIPECALVAILDADKEGFLRSRTSLIQTIGRAARNVGGRVILYADKMTDSLTFAIEE
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHH
TSRRRQRQQDYNAAHGITPETVRSRISDVLSSVYEKDYVTVTTGVSGDNQLVGKSLREHL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
ADLDKRMRAAAADLEFEEAGRLRDEIRRLEALDLGLPGDAGATGLAEAAIPLRAAVAKGR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
GAAAKGRGRKGKR
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]