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The map label for this gene is ldh [H]

Identifier: 83592376

GI number: 83592376

Start: 1233049

End: 1234149

Strand: Reverse

Name: ldh [H]

Synonym: Rru_A1040

Alternate gene names: 83592376

Gene position: 1234149-1233049 (Counterclockwise)

Preceding gene: 83592379

Following gene: 83592375

Centisome position: 28.35

GC content: 70.12

Gene sequence:

>1101_bases
ATGAGCATTTTTTTCGCCGACCCCTTCGACGATCACGAAAGCGTCGTCTTCGCCCGCGACGCCGCCTCGGGTCTGCGCGC
CATCATCGCCATTCACAGCACCGCCCTTGGCCCCGCCGTTGGCGGCTGCCGGATGTGGCCCTATCGCAGCGAGGAAGAGG
CCCTGGCCGATGTGCTGCGGCTGTCGCGGGCCATGAGCTACAAGAACGCCCTGGCCGGTCTGGCTTTGGGCGGCGGCAAG
GCGGTGATCCTGGGCGAGTCGCGGAGCGAAAAATCGCCCGAGCTGCTGCGGGCCTTCGGCCGCGCCGTCGACCGCCTGGG
CGGCGCCTATCGCACCGCCGAGGATGTCGGCACCTCGGCGGCCGATATGGACATCATCGGCGAGGAAACCCGCCATGCGC
TGGGCCGCTCGGCCAAAGGCGCCGTCACCGTCGGCGATCCCTCGCCCTATACGGCGCGTGGCGGGCTGGCGGCCATGCGC
GCCGCCGTCCGCCATCGCTTGGGCCGTGACGGGTTGGCCGGCCTTACCATCGCCATTCAAGGCTGCGGCCAGGTTGGCGC
CCATCTCGCCCGCCTGCTCCAGGCCGAAGGCGCCCTGGTGGTGGTCGCCGATCTCGATCCGGCCCGCGCCAGGGCCCTGG
CCGGGGAGACCGGCGCCGTGGCGGTCGAGGCCGACCGTATTCTTTCGATCAAAGCCGATGTGATGGCCCCTTGCGCCCTG
GGGGCTATACTCGACGATCAGGTCATCGCCGCGCTCAACGTTCCGATCGTCGCCGGTCTGGCCAACAACCAGCTTGCCCA
GCCCCGCCATGCCGCCCTGCTCCACGACCGGGGCATCCTTTATGTTCCCGATTACGTCGCCAATGCCGGCGGCATCATCG
CCATCGCCGCCGAACACGATGGCCGGGTCGACCGCGCGGAAATCCTCGGGAAAATCGAAGGGATCGGCGCGACAACGGCG
AAAATCCTTGATCGCGCGGTGCGCGAGAACCGCACCACCGCCGTCATTGCCGACACCCTGGCCCGCGAAAGGCTGGCCGC
CGCCAGCCCCCGGCCCGCCGCCGCCCAGCCCCGGCGTCAGGCCGGCCGCGCCTTGGGCTGA

Upstream 100 bases:

>100_bases
CTGGGCGGCGGCCGTTGACCCGGCCGGCGCCGCCGGCCATGTGCTTGACATAAGAAGCGATCGAAACAAATCGCGCCGAT
GGCCCCAGGGAGAGAGTCCG

Downstream 100 bases:

>100_bases
GCGCGCCGCCGTTTTCCCCTCTCCCGCCGGTTGGGCAACGTTTACGCCTTATCAATCGTTTAGGGCTACGTTCTGAAGTA
GCGAAGCAACTAAGAGCGCT

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSIFFADPFDDHESVVFARDAASGLRAIIAIHSTALGPAVGGCRMWPYRSEEEALADVLRLSRAMSYKNALAGLALGGGK
AVILGESRSEKSPELLRAFGRAVDRLGGAYRTAEDVGTSAADMDIIGEETRHALGRSAKGAVTVGDPSPYTARGGLAAMR
AAVRHRLGRDGLAGLTIAIQGCGQVGAHLARLLQAEGALVVVADLDPARARALAGETGAVAVEADRILSIKADVMAPCAL
GAILDDQVIAALNVPIVAGLANNQLAQPRHAALLHDRGILYVPDYVANAGGIIAIAAEHDGRVDRAEILGKIEGIGATTA
KILDRAVRENRTTAVIADTLARERLAAASPRPAAAQPRRQAGRALG

Sequences:

>Translated_366_residues
MSIFFADPFDDHESVVFARDAASGLRAIIAIHSTALGPAVGGCRMWPYRSEEEALADVLRLSRAMSYKNALAGLALGGGK
AVILGESRSEKSPELLRAFGRAVDRLGGAYRTAEDVGTSAADMDIIGEETRHALGRSAKGAVTVGDPSPYTARGGLAAMR
AAVRHRLGRDGLAGLTIAIQGCGQVGAHLARLLQAEGALVVVADLDPARARALAGETGAVAVEADRILSIKADVMAPCAL
GAILDDQVIAALNVPIVAGLANNQLAQPRHAALLHDRGILYVPDYVANAGGIIAIAAEHDGRVDRAEILGKIEGIGATTA
KILDRAVRENRTTAVIADTLARERLAAASPRPAAAQPRRQAGRALG
>Mature_365_residues
SIFFADPFDDHESVVFARDAASGLRAIIAIHSTALGPAVGGCRMWPYRSEEEALADVLRLSRAMSYKNALAGLALGGGKA
VILGESRSEKSPELLRAFGRAVDRLGGAYRTAEDVGTSAADMDIIGEETRHALGRSAKGAVTVGDPSPYTARGGLAAMRA
AVRHRLGRDGLAGLTIAIQGCGQVGAHLARLLQAEGALVVVADLDPARARALAGETGAVAVEADRILSIKADVMAPCALG
AILDDQVIAALNVPIVAGLANNQLAQPRHAALLHDRGILYVPDYVANAGGIIAIAAEHDGRVDRAEILGKIEGIGATTAK
ILDRAVRENRTTAVIADTLARERLAAASPRPAAAQPRRQAGRALG

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Drosophila melanogaster, GI45549226, Length=306, Percent_Identity=26.797385620915, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45553475, Length=306, Percent_Identity=26.797385620915, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 37891; Mature: 37760

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFFADPFDDHESVVFARDAASGLRAIIAIHSTALGPAVGGCRMWPYRSEEEALADVLR
CEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LSRAMSYKNALAGLALGGGKAVILGESRSEKSPELLRAFGRAVDRLGGAYRTAEDVGTSA
HHHHHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADMDIIGEETRHALGRSAKGAVTVGDPSPYTARGGLAAMRAAVRHRLGRDGLAGLTIAIQ
CCHHHHCHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
GCGQVGAHLARLLQAEGALVVVADLDPARARALAGETGAVAVEADRILSIKADVMAPCAL
CCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEECCCEEEEHHHHHHHHHH
GAILDDQVIAALNVPIVAGLANNQLAQPRHAALLHDRGILYVPDYVANAGGIIAIAAEHD
HHHHCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCEEECCHHHCCCCCEEEEEECCC
GRVDRAEILGKIEGIGATTAKILDRAVRENRTTAVIADTLARERLAAASPRPAAAQPRRQ
CCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
AGRALG
CCCCCC
>Mature Secondary Structure 
SIFFADPFDDHESVVFARDAASGLRAIIAIHSTALGPAVGGCRMWPYRSEEEALADVLR
EEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LSRAMSYKNALAGLALGGGKAVILGESRSEKSPELLRAFGRAVDRLGGAYRTAEDVGTSA
HHHHHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCC
ADMDIIGEETRHALGRSAKGAVTVGDPSPYTARGGLAAMRAAVRHRLGRDGLAGLTIAIQ
CCHHHHCHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
GCGQVGAHLARLLQAEGALVVVADLDPARARALAGETGAVAVEADRILSIKADVMAPCAL
CCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEECCCEEEEHHHHHHHHHH
GAILDDQVIAALNVPIVAGLANNQLAQPRHAALLHDRGILYVPDYVANAGGIIAIAAEHD
HHHHCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCEEECCHHHCCCCCEEEEEECCC
GRVDRAEILGKIEGIGATTAKILDRAVRENRTTAVIADTLARERLAAASPRPAAAQPRRQ
CCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
AGRALG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]