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The map label for this gene is lpxC [H]

Identifier: 83592279

GI number: 83592279

Start: 1124295

End: 1125338

Strand: Reverse

Name: lpxC [H]

Synonym: Rru_A0943

Alternate gene names: 83592279

Gene position: 1125338-1124295 (Counterclockwise)

Preceding gene: 83592280

Following gene: 83592277

Centisome position: 25.85

GC content: 66.95

Gene sequence:

>1044_bases
ATGGACGGTCTCAATTACGATATCGACACCTCCTTTGAGGACCGCTCTTCGTCCCGCAGTTCCAGCCGCGCCAAAGCCGG
CCTTGGCGTGATCGCCAGCGGCATCGCCCGCCAGCACACCTTGAAAACCGCCATCAGTTGCACCGGCGTCGGCGTCCATC
GCGGCCGCGAGGCCACCTTGACCCTGCGTCCGGCCCCCGTCGATACGGGCATCGTTTTCAACCGCACCGACATCCTTGAT
GACAACGCCGCCATCCGCGTCAGCGCCCAGGCGGTGATCGACGGCCGGCTGTGCACGACCATCGCCAACGAGGCCGGCGC
CACGGTTTCCACGGTCGAGCACCTGATGGCCGCCTTCGCCGCCCAGGGCATCGACAATGTGATCGTCGATGTCAACGGCC
CGGAAGTGCCGATCATGGACGGCAGCGCCGCCCCCTTCGTTTTCCTCATCGATTGCGCCGGGGTGGTCGACCAGGCGCTT
CCGCGCAAGGCGATCCGCGTCCGCAAGGCGGTGACCGTGGTCGAAGGCCCGGTTCTCGCCAGCCTGATGCCGGCCGAGCG
CGGCCTGTCGGTTGATTTCGAAATCGATTTCGCCGCCCGCGCCATCGGTCGCCAGGGCTGCCACGTCGATCTCACCCCCG
ACCTGTTCCGCGCCCATATCGCCCGCGCCCGCACCTTCGGCCTGCGCTCCGATGTCGATATGATGCGCGCCGCCGGCCTT
GGCCTGGGCGGCTCGCTGGAAAACGCCGTGGTCGTCGACGACGATCTGATCCTCAACGACGAGGGCCTGCGCTACGAAGA
GGAATTCGTGCGTCACAAGGCGCTGGACGCCATCGGCGATCTTTATATGGCCGGGGCGCCGATCATCGGCCGCTATCACG
GCGTGCGCTCCAGCCACGCCCATAACAACAAGCTGGTCCGCGCCCTGCTGGCCGATCCGGCCAATTACAGCCTGGAAACC
GTTGACGAGACCGATCTCGCCGCCCCGGGCCAGGGCCGTTTCGACGGCTGGCGCGATACCGACCGCATCGCCGCCACCGC
CTGA

Upstream 100 bases:

>100_bases
AGAGAACGAGATCCCGGCGAGATCGGGAACCTTCCGTGGGCAGGAGCCCCCACCGCGTCGGCACCGGGTCGACGTTCCAG
AGACGAAGAGGCGCACGACC

Downstream 100 bases:

>100_bases
GCCCGCCGGGCCGCCCGCCCGGTCTCTCGCCGCTCCGACCGGCCGGTTGGCCGGCCCCGGCCGGGGGCGCCAAAGCCGGA
CCGGCCGCCGTTCAGCACGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDGLNYDIDTSFEDRSSSRSSSRAKAGLGVIASGIARQHTLKTAISCTGVGVHRGREATLTLRPAPVDTGIVFNRTDILD
DNAAIRVSAQAVIDGRLCTTIANEAGATVSTVEHLMAAFAAQGIDNVIVDVNGPEVPIMDGSAAPFVFLIDCAGVVDQAL
PRKAIRVRKAVTVVEGPVLASLMPAERGLSVDFEIDFAARAIGRQGCHVDLTPDLFRAHIARARTFGLRSDVDMMRAAGL
GLGGSLENAVVVDDDLILNDEGLRYEEEFVRHKALDAIGDLYMAGAPIIGRYHGVRSSHAHNNKLVRALLADPANYSLET
VDETDLAAPGQGRFDGWRDTDRIAATA

Sequences:

>Translated_347_residues
MDGLNYDIDTSFEDRSSSRSSSRAKAGLGVIASGIARQHTLKTAISCTGVGVHRGREATLTLRPAPVDTGIVFNRTDILD
DNAAIRVSAQAVIDGRLCTTIANEAGATVSTVEHLMAAFAAQGIDNVIVDVNGPEVPIMDGSAAPFVFLIDCAGVVDQAL
PRKAIRVRKAVTVVEGPVLASLMPAERGLSVDFEIDFAARAIGRQGCHVDLTPDLFRAHIARARTFGLRSDVDMMRAAGL
GLGGSLENAVVVDDDLILNDEGLRYEEEFVRHKALDAIGDLYMAGAPIIGRYHGVRSSHAHNNKLVRALLADPANYSLET
VDETDLAAPGQGRFDGWRDTDRIAATA
>Mature_347_residues
MDGLNYDIDTSFEDRSSSRSSSRAKAGLGVIASGIARQHTLKTAISCTGVGVHRGREATLTLRPAPVDTGIVFNRTDILD
DNAAIRVSAQAVIDGRLCTTIANEAGATVSTVEHLMAAFAAQGIDNVIVDVNGPEVPIMDGSAAPFVFLIDCAGVVDQAL
PRKAIRVRKAVTVVEGPVLASLMPAERGLSVDFEIDFAARAIGRQGCHVDLTPDLFRAHIARARTFGLRSDVDMMRAAGL
GLGGSLENAVVVDDDLILNDEGLRYEEEFVRHKALDAIGDLYMAGAPIIGRYHGVRSSHAHNNKLVRALLADPANYSLET
VDETDLAAPGQGRFDGWRDTDRIAATA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=291, Percent_Identity=46.7353951890034, Blast_Score=265, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 36912; Mature: 36912

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGLNYDIDTSFEDRSSSRSSSRAKAGLGVIASGIARQHTLKTAISCTGVGVHRGREATL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCEEE
TLRPAPVDTGIVFNRTDILDDNAAIRVSAQAVIDGRLCTTIANEAGATVSTVEHLMAAFA
EEECCCCCCCEEEECCEECCCCCEEEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
AQGIDNVIVDVNGPEVPIMDGSAAPFVFLIDCAGVVDQALPRKAIRVRKAVTVVEGPVLA
HCCCCEEEEECCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLMPAERGLSVDFEIDFAARAIGRQGCHVDLTPDLFRAHIARARTFGLRSDVDMMRAAGL
HHCCCCCCCEEEEEECHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GLGGSLENAVVVDDDLILNDEGLRYEEEFVRHKALDAIGDLYMAGAPIIGRYHGVRSSHA
CCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
HNNKLVRALLADPANYSLETVDETDLAAPGQGRFDGWRDTDRIAATA
CCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MDGLNYDIDTSFEDRSSSRSSSRAKAGLGVIASGIARQHTLKTAISCTGVGVHRGREATL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCEEE
TLRPAPVDTGIVFNRTDILDDNAAIRVSAQAVIDGRLCTTIANEAGATVSTVEHLMAAFA
EEECCCCCCCEEEECCEECCCCCEEEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
AQGIDNVIVDVNGPEVPIMDGSAAPFVFLIDCAGVVDQALPRKAIRVRKAVTVVEGPVLA
HCCCCEEEEECCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLMPAERGLSVDFEIDFAARAIGRQGCHVDLTPDLFRAHIARARTFGLRSDVDMMRAAGL
HHCCCCCCCEEEEEECHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GLGGSLENAVVVDDDLILNDEGLRYEEEFVRHKALDAIGDLYMAGAPIIGRYHGVRSSHA
CCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
HNNKLVRALLADPANYSLETVDETDLAAPGQGRFDGWRDTDRIAATA
CCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA