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The map label for this gene is apt

Identifier: 83591946

GI number: 83591946

Start: 719392

End: 719907

Strand: Reverse

Name: apt

Synonym: Rru_A0607

Alternate gene names: 83591946

Gene position: 719907-719392 (Counterclockwise)

Preceding gene: 83591951

Following gene: 83591931

Centisome position: 16.54

GC content: 63.76

Gene sequence:

>516_bases
ATGAACCTTAAGGACCATATTCGTGAAGTCCCCGATTTTCCCAAGCCGGGGATTCTCTTTTACGATATCTCGACGTTGCT
GGCCGATCCCGACGCCTGGCAGGTCACCATGGGGCGAATGGCCAAAGTGGTCGCCCCGCGCCTGCCCGATGTTCTGGCCG
GCATCGAATCCCGCGGCTTCCTGGTCGCCGCCCCGCTCGCCCTCAAGCTTGGGCTGGGCTTCGTCATGGTCCGCAAGAAG
GGCAAACTGCCCGGCGCCACCGTCCGCCACGAATACGCCCTGGAATATGGCACCGACACCGTCGAGGTCCAGGAAGGCGC
CGTTCTGCCCGGCCAACGCGTGGTGATCCTCGATGACCTGCTGGCCACCGGCGGCACGCTCAACGCCGCCTCGGAATTGC
TTGGCAAGATGGGCGCCAATGTCGTCGGCGCCGCCTGCATCATCGAGCTGAGTTTCCTCAAGGGCCGCGAGCGCACCAAG
GTTCCCATCGACAGCCTCGTCGCCTACGACTCCTAA

Upstream 100 bases:

>100_bases
CGACAACGGCCCCAGGAACTCCGTGGATATTCAGGGTTTCGGCCCGCCCCCGGGGCGGTTAGGATCCGCTGCCGTCCCGT
CGCCCCACCCGGAGAGTTCG

Downstream 100 bases:

>100_bases
CCCCCCCCTCCGGTGGCCCCTCTCCTGCCCTGGGGGGCCTACCGGCAGCCGATCATGGCCAGAAAGGCGTCCTCGGCCCG
GCCATGGGCGCGATCGCCAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MNLKDHIREVPDFPKPGILFYDISTLLADPDAWQVTMGRMAKVVAPRLPDVLAGIESRGFLVAAPLALKLGLGFVMVRKK
GKLPGATVRHEYALEYGTDTVEVQEGAVLPGQRVVILDDLLATGGTLNAASELLGKMGANVVGAACIIELSFLKGRERTK
VPIDSLVAYDS

Sequences:

>Translated_171_residues
MNLKDHIREVPDFPKPGILFYDISTLLADPDAWQVTMGRMAKVVAPRLPDVLAGIESRGFLVAAPLALKLGLGFVMVRKK
GKLPGATVRHEYALEYGTDTVEVQEGAVLPGQRVVILDDLLATGGTLNAASELLGKMGANVVGAACIIELSFLKGRERTK
VPIDSLVAYDS
>Mature_171_residues
MNLKDHIREVPDFPKPGILFYDISTLLADPDAWQVTMGRMAKVVAPRLPDVLAGIESRGFLVAAPLALKLGLGFVMVRKK
GKLPGATVRHEYALEYGTDTVEVQEGAVLPGQRVVILDDLLATGGTLNAASELLGKMGANVVGAACIIELSFLKGRERTK
VPIDSLVAYDS

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=173, Percent_Identity=49.1329479768786, Blast_Score=164, Evalue=3e-41,
Organism=Homo sapiens, GI71773201, Length=126, Percent_Identity=49.2063492063492, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=156, Percent_Identity=46.7948717948718, Blast_Score=144, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17509087, Length=177, Percent_Identity=46.3276836158192, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323619, Length=169, Percent_Identity=40.8284023668639, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=33.5294117647059, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136334, Length=169, Percent_Identity=47.9289940828402, Blast_Score=146, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_RHORT (Q2RWT4)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425698.1
- HSSP:   P07741
- ProteinModelPortal:   Q2RWT4
- SMR:   Q2RWT4
- STRING:   Q2RWT4
- GeneID:   3833980
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0607
- NMPDR:   fig|1085.1.peg.1734
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q2RWT4
- ProtClustDB:   PRK02304
- BioCyc:   RRUB269796:RRU_A0607-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18313; Mature: 18313

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDHIREVPDFPKPGILFYDISTLLADPDAWQVTMGRMAKVVAPRLPDVLAGIESRGF
CCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCE
LVAAPLALKLGLGFVMVRKKGKLPGATVRHEYALEYGTDTVEVQEGAVLPGQRVVILDDL
EEECHHHHHHCCCEEEEEECCCCCCCCHHHEEEHCCCCCEEEECCCCCCCCCEEEEEEHH
LATGGTLNAASELLGKMGANVVGAACIIELSFLKGRERTKVPIDSLVAYDS
HHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MNLKDHIREVPDFPKPGILFYDISTLLADPDAWQVTMGRMAKVVAPRLPDVLAGIESRGF
CCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCE
LVAAPLALKLGLGFVMVRKKGKLPGATVRHEYALEYGTDTVEVQEGAVLPGQRVVILDDL
EEECHHHHHHCCCEEEEEECCCCCCCCHHHEEEHCCCCCEEEECCCCCCCCCEEEEEEHH
LATGGTLNAASELLGKMGANVVGAACIIELSFLKGRERTKVPIDSLVAYDS
HHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA