Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 83591921

GI number: 83591921

Start: 691305

End: 692300

Strand: Direct

Name: lpxK

Synonym: Rru_A0582

Alternate gene names: 83591921

Gene position: 691305-692300 (Clockwise)

Preceding gene: 83591920

Following gene: 83591922

Centisome position: 15.88

GC content: 69.88

Gene sequence:

>996_bases
GTGCGCGCCCCTGAGTTCTGGCATAAGGACGGCTTCGCCGCCCGCCTGCTCGAACCGGTCGGGCTGGTCTATGCGGCGCT
GACCCGCCACCGGGTGGCCCGTCCGCCCGGGGTGCGCCTGGGGATTCCCGTCGTCTGCGTCGGCAATCTGACCGCCGGCG
GAGCGGGCAAGACTCCGGTGGCCCTGGCGGTGATGGACGCCTTGCGCCGGCGCGGCGTGGTCGGGCATTTCCTGTCGCGC
GGCTATGGCGGCAAGATGGAAGGGCCCGTCGCCGTCGATCCGGTGGGCCATGGCCCGGAAGATGTCGGCGACGAACCGCT
GCTGCTGGCCAATAGCGCGCCCTGCTGGGTCTCGCGCAACCGGGCGAGCGGCGGATTGGTCGCCGAAGGGGCCGGGGCCC
AGGCAGTGGTGATGGATGATGGCCATCAGAACCCCTCCCTGGCCAAGGATCTGTCGCTGGTTGTCGTTGACGGCGGTTAT
GGCTTTGGCAATGGCCGCTATATCCCCGCCGGTCCCTTGCGCGAATCGATCGAGGCCGGGCTGGCGCGGGCCGGGGCGGT
GATCCTGATCGGGTCCGATAGCGAAAATCTGGCGGCGCGCATCCCGCCCCACCTCAAGGCCGGGGTGCCGCTGCTCACCG
CCCGCCTGGAACCGGGCCCCGAGGCGGCGCGGCTGGTCGGGCGCAAGGTGGTGGCCTTCGCCGGCATCGGCCGTCCCGAA
AAGTTCTTCGCCACCCTGACGGCTTTGGGGGCCCGGGTGGTCGCCCGCCACCCCTTCGCCGACCATTACCCTTACGCCGA
AGCCGATATTCAGCCGATCCTTGACGAGGCCTATGGCCTGGGGGCGGTGCCGGTGACGACCTCGAAGGACGCGGTGCGTC
TTCCCCCCGATCAGCGCCCACAGGTGGACGTGGTGGGGGTGCGGGTGGTATTCGATGAACCACTGGCTTTCGAAGCCCTG
ATCGACCGTCTGATCCTGGGCCGCCTCCCGTCGTAA

Upstream 100 bases:

>100_bases
GGCGAAAGGGCGGTTCTCGACCGCGTCCTTGGCTGCCTTGCCCCGTTCCTCGACGTCCTGACGCCGCTTGCCCCCACCCC
CTCCCTGCGCGAGGCCGGCG

Downstream 100 bases:

>100_bases
AAGGCTCTTTGGACGATGATCAAGGTCGCCGTGCTTGTTACCCTTCCTTGGACGGCGGATGCCGGGGGGCATGTCAAGGT
CTGGGAGCGTTTCGCCGAAG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPVALAVMDALRRRGVVGHFLSR
GYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRNRASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGY
GFGNGRYIPAGPLRESIEAGLARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPE
KFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRPQVDVVGVRVVFDEPLAFEAL
IDRLILGRLPS

Sequences:

>Translated_331_residues
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPVALAVMDALRRRGVVGHFLSR
GYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRNRASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGY
GFGNGRYIPAGPLRESIEAGLARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPE
KFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRPQVDVVGVRVVFDEPLAFEAL
IDRLILGRLPS
>Mature_331_residues
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPVALAVMDALRRRGVVGHFLSR
GYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRNRASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGY
GFGNGRYIPAGPLRESIEAGLARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPE
KFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRPQVDVVGVRVVFDEPLAFEAL
IDRLILGRLPS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=299, Percent_Identity=36.7892976588629, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_RHORT (Q2RWV9)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425673.1
- STRING:   Q2RWV9
- GeneID:   3834472
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0582
- NMPDR:   fig|1085.1.peg.1758
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q2RWV9
- ProtClustDB:   PRK00652
- BioCyc:   RRUB269796:RRU_A0582-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34631; Mature: 34631

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCCCCCCHH
ALAVMDALRRRGVVGHFLSRGYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRN
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECCCCCCCHHCCCCCEEEECCCCCEEECC
RASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGYGFGNGRYIPAGPLRESIEAG
CCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEECCCCHHHHHHHHH
LARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPE
HHHCCEEEEEECCCCCCEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHEEEECCCCHH
KFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCEECCCCCCC
QVDVVGVRVVFDEPLAFEALIDRLILGRLPS
CEEEEEEEEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRAPEFWHKDGFAARLLEPVGLVYAALTRHRVARPPGVRLGIPVVCVGNLTAGGAGKTPV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCCCCCCHH
ALAVMDALRRRGVVGHFLSRGYGGKMEGPVAVDPVGHGPEDVGDEPLLLANSAPCWVSRN
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECCCCCCCHHCCCCCEEEECCCCCEEECC
RASGGLVAEGAGAQAVVMDDGHQNPSLAKDLSLVVVDGGYGFGNGRYIPAGPLRESIEAG
CCCCCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEECCCCHHHHHHHHH
LARAGAVILIGSDSENLAARIPPHLKAGVPLLTARLEPGPEAARLVGRKVVAFAGIGRPE
HHHCCEEEEEECCCCCCEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHEEEECCCCHH
KFFATLTALGARVVARHPFADHYPYAEADIQPILDEAYGLGAVPVTTSKDAVRLPPDQRP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCEECCCCCCC
QVDVVGVRVVFDEPLAFEALIDRLILGRLPS
CEEEEEEEEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA